Interleukin-12 can directly induce T-helper 1 responses in interferon-gamma (IFN-gamma) receptor-deficient mice, but requires IFN-gamma signalling to downregulate T-helper 2 responses (Q78157751)

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scientific article published on 01 August 1999

Language	Label	Description	Also known as
English	Interleukin-12 can directly induce T-helper 1 responses in interferon-gamma (IFN-gamma) receptor-deficient mice, but requires IFN-gamma signalling to downregulate T-helper 2 responses	scientific article published on 01 August 1999

Statements

scholarly article

1 reference

Europe PubMed Central

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11 December 2019

Interleukin-12 can directly induce T-helper 1 responses in interferon-gamma (IFN-gamma) receptor-deficient mice, but requires IFN-gamma signalling to downregulate T-helper 2 responses (English)

1 reference

Europe PubMed Central

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11 December 2019

author name string

A P Mountford

1

1 reference

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11 December 2019

P S Coulson

2

1 reference

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11 December 2019

A W Cheever

3

1 reference

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11 December 2019

A Sher

4

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11 December 2019

R A Wilson

5

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11 December 2019

T A Wynn

6

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11 December 2019

publication date

1 August 1999

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11 December 2019

1 reference

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11 December 2019

97

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11 December 2019

4

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11 December 2019

588-594

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11 December 2019

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta+, TCR-gamma delta+ T lymphocytes, and NK cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune response in mice that lack the interferon-gamma receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lymphokine regulation of granuloma formation in murine schistosomiasis mansoni

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brucella abortus induces a novel cytokine gene expression pattern characterized by elevated IL-10 and IFN-gamma in CD4+ T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of IL-12 on helper T cell-dependent immune responses in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-12 inhibits Th2 cytokine responses induced by eggs of Schistosoma mansoni.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IFN-gamma receptor-deficient mice generate antiviral Th1-characteristic cytokine profiles but altered antibody responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in TH1 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning of a new cytokine that induces IFN-gamma production by T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of interferon-gamma receptor does not influence the outcome of infection in murine schistosomiasis mansoni

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant IL-10 and IL-10/Fc treatment down-regulate egg antigen-specific delayed hypersensitivity reactions and egg granuloma formation in schistosomiasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired immunity and altered pulmonary responses in mice with a disrupted interferon-gamma receptor gene exposed to the irradiated Schistosoma mansoni vaccine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-12: a proinflammatory cytokine with immunoregulatory functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking the gamma interferon receptor have an impaired granulomatous reaction to Schistosoma mansoni infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-1 alpha and TNF-alpha are required for IL-12-induced development of Th1 cells producing high levels of IFN-gamma in BALB/c but not C57BL/6 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice from a genetically resistant background lacking the interferon gamma receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of IL-4 and IFN-gamma in Schistosoma mansoni egg-induced hypersensitivity granuloma formation. Orchestration, relative contribution, and relationship to macrophage function

1 reference

https://pubmed.ncbi.nlm.nih.gov/10457211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1046/J.1365-2567.1999.00832.X

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10457211%20AND%20SRC:MED&resulttype=core&format=json

11 December 2019

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10457211%20AND%20SRC:MED&resulttype=core&format=json

11 December 2019

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