Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677: functional relevance to pharmacokinetics of digoxin (Q78498308)

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14 December 2019

title

Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677: functional relevance to pharmacokinetics of digoxin (English)

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14 December 2019

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3

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14 December 2019

author name string

Masanori Horinouchi

1

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14 December 2019

Toshiyuki Sakaeda

2

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14 December 2019

Yoshinori Morita

4

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14 December 2019

Takao Tamura

5

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14 December 2019

Nobuo Aoyama

6

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14 December 2019

Masato Kasuga

7

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14 December 2019

Katsuhiko Okumura

8

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14 December 2019

publication date

1 October 2002

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14 December 2019

published in

Pharmaceutical Research

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14 December 2019

volume

19

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14 December 2019

page(s)

1581-1585

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14 December 2019

issue

10

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No influence of the MDR-1 C3435T polymorphism or a CYP3A4 promoter polymorphism (CYP3A4-V allele) on dose-adjusted cyclosporin A trough concentrations or rejection incidence in stable renal transplant recipients

14 December 2019

cites work

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12 December 2020

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

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12 December 2020

Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects

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12 December 2020

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

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12 December 2020

Effect of grapefruit juice on digoxin pharmacokinetics in humans.

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12 December 2020

MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity

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12 December 2020

Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.

1 reference

12 December 2020

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

1 reference

12 December 2020

Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors.

1 reference

12 December 2020

P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance.

1 reference

12 December 2020

Identification of functionally variant MDR1 alleles among European Americans and African Americans

1 reference

12 December 2020

Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects.

1 reference

12 December 2020

Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene

1 reference

12 December 2020

The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells

1 reference

12 December 2020

MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects

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12 December 2020

Identifiers

DOI

10.1023/A:1020433422259

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14 December 2019

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