Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer (Q78666620)

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15 December 2019

title

Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer (English)

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15 December 2019

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4

Fosså SD

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15 December 2019

author name string

Smith-Sørensen B

1

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15 December 2019

Lind GE

2

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15 December 2019

Skotheim RI

3

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15 December 2019

Fodstad Ø

5

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15 December 2019

Stenwig AE

6

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15 December 2019

Jakobsen KS

7

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15 December 2019

Lothe RA

8

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15 December 2019

language of work or name

English

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publication date

1 December 2002

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15 December 2019

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15 December 2019

volume

21

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15 December 2019

issue

57

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15 December 2019

page(s)

8878-8884

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205978

15 December 2019

exact match

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DNA hypermethylation in tumorigenesis: epigenetics joins genetics

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Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

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Epigenetic lesions causing genetic lesions in human cancer: promoter hypermethylation of DNA repair genes

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

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Allelic losses in carcinoma in situ and testicular germ cell tumours of adolescents and adults: evidence suggestive of the linear progression model

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Identification of a 59 bp enhancer located at the first exon/intron boundary of the human O6-methylguanine DNA methyltransferase gene

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7 January 2021

Molecular analysis of P16(Ink4)/CDKN2 and P15(INK4B)/MTS2 genes in primary human testicular germ cell tumors

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Molecular genetic parameters in pathogenesis and prognosis of testicular germ cell tumors

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

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Salvage treatment in male patients with germ cell tumours

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Frequent loss of 11p13 and 11p15 loci in male germ cell tumours

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Susceptibility to testicular germ-cell tumours in a 129.MOLF-Chr 19 chromosome substitution strain

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5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

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7 January 2021

Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C --> A:T mutations of the TP53 tumor suppressor gene

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Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

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Protective effect of O6-methylguanine-DNA methyltransferase (MGMT) on the cytotoxic and recombinogenic activity of different antineoplastic drugs

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7 January 2021

Localization of methylation sites in the human O6-methylguanine-DNA methyltransferase promoter: correlation with gene suppression

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Correlation of p16 hypermethylation with p16 protein loss in sporadic gastric carcinomas.

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Familial/bilateral and sporadic testicular germ cell tumors show frequent genetic changes at loci with suggestive linkage evidence

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Evaluation of loss of heterozygosity/allelic imbalance scoring in tumor DNA

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A new tool for the rapid cloning of amplified and hypermethylated human DNA sequences from restriction landmark genome scanning gels

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7 January 2021

Distinct epigenetic phenotypes in seminomatous and nonseminomatous testicular germ cell tumors

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