Integrin alpha2beta1 inhibits Fas-mediated apoptosis in T lymphocytes by protein phosphatase 2A-dependent activation of the MAPK/ERK pathway (Q78758328)

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scientific article published on 17 September 2003

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English	Integrin alpha2beta1 inhibits Fas-mediated apoptosis in T lymphocytes by protein phosphatase 2A-dependent activation of the MAPK/ERK pathway	scientific article published on 17 September 2003

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16 December 2019

Integrin alpha2beta1 inhibits Fas-mediated apoptosis in T lymphocytes by protein phosphatase 2A-dependent activation of the MAPK/ERK pathway (English)

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16 December 2019

author name string

Steve Gendron

1

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16 December 2019

Julie Couture

2

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16 December 2019

Fawzi Aoudjit

3

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17 September 2003

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11

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Journal of Biological Chemistry

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278

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16 December 2019

48633-48643

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16 December 2019

Integrins: emerging paradigms of signal transduction

1 reference

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Integrin signaling

1 reference

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Anoikis mechanisms

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Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells

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Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis

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Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis.

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Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo

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Integrin signaling: it's where the action is.

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Get a ligand, get a life: integrins, signaling and cell survival

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Alpha 4 integrin signaling activates phosphatidylinositol 3-kinase and stimulates T cell adhesion to intercellular adhesion molecule-1 to a similar extent as CD3, but induces a distinct rearrangement of the actin cytoskeleton

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Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

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Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas.

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Activation of beta(1) integrins mediates proliferation and inhibits apoptosis of intestinal CD4-positive lymphocytes

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Resistance of cultured peripheral T cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing signaling complex

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An investigation of the substrate specificity of protein phosphatase 2C using synthetic peptide substrates; comparison with protein phosphatase 2A

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MAPK/ERK signaling in activated T cells inhibits CD95/Fas-mediated apoptosis downstream of DISC assembly

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21 January 2018

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

1 reference

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21 January 2018

Fas, ceramide and serum withdrawal induce apoptosis via a common pathway in a type II Jurkat cell line.

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21 January 2018

Phorbol 12-myristate 13-acetate inhibits death receptor-mediated apoptosis in Jurkat cells by disrupting recruitment of Fas-associated polypeptide with death domain

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21 January 2018

Inhibition of mitogen-activated kinase signaling sensitizes HeLa cells to Fas receptor-mediated apoptosis

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21 January 2018

Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.

1 reference

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21 January 2018

Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation

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21 January 2018

Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits

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Usage of tautomycetin, a novel inhibitor of protein phosphatase 1 (PP1), reveals that PP1 is a positive regulator of Raf-1 in vivo.

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21 January 2018

An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues

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21 January 2018

Combined action of ERK and NF kappa B mediates the protective effect of phorbol ester on Fas-induced apoptosis in Jurkat cells

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21 January 2018

Mitogen-activated protein kinase kinase antagonized fas-associated death domain protein-mediated apoptosis by induced FLICE-inhibitory protein expression

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Identifiers

10.1074/JBC.M305169200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:13679375%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:13679375%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

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