Ubiquitin C-terminal hydrolase L1 (Q7876540)

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mammalian protein found in Homo sapiens

ubiquitin carboxyl-terminal hydrolase isozyme L1
UCHL1
PGP9.5
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
PGP 9.5
neuron cytoplasmic protein 9.5
epididymis secretory protein Li 53
epididymis luminal protein 117
ubiquitin thiolesterase
ubiquitin thioesterase L1

Language	Label	Description	Also known as
English	Ubiquitin C-terminal hydrolase L1	mammalian protein found in Homo sapiens	ubiquitin carboxyl-terminal hydrolase isozyme L1 UCHL1 PGP9.5 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) PGP 9.5 neuron cytoplasmic protein 9.5 epididymis secretory protein Li 53 epididymis luminal protein 117 ubiquitin thiolesterase ubiquitin thioesterase L1

Statements

1 reference

13 November 2019

UniProt protein ID

Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P09936

Papain-like cysteine peptidase superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P09936

Ubiquitin carboxyl-terminal hydrolase L1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P09936

Peptidase C12, ubiquitin carboxyl-terminal hydrolase family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

cysteine-type peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

ligase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

protein binding

determination method

3 references

8 April 2019

Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

8 April 2019

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

8 April 2019

Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1)

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

alpha-2A adrenergic receptor binding

determination method

1 reference

8 April 2019

Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

omega peptidase activity

determination method

1 reference

8 April 2019

Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

cysteine-type endopeptidase activity

determination method

1 reference

8 April 2019

Substrate binding and catalysis by ubiquitin C-terminal hydrolases: identification of two active site residues

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

ubiquitin protein ligase binding

determination method

1 reference

8 April 2019

Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

thiol-dependent deubiquitinase

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

8 April 2019

Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

determination method

5 references

27 March 2018

Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09936&geneProductId=UniProtKB:P09936

determination method

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09936&geneProductId=UniProtKB:P09936

determination method

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09936&geneProductId=UniProtKB:P09936

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09936&geneProductId=UniProtKB:P09936

determination method

27 March 2018

Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09936&geneProductId=UniProtKB:P09936

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

endoplasmic reticulum membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

determination method

1 reference

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09936&geneProductId=UniProtKB:P09936

determination method

plasma membrane

determination method

1 reference

8 April 2019

Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

intracellular anatomical structure

determination method

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09936&geneProductId=UniProtKB:P09936

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

neuronal cell body

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

endoplasmic reticulum

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

neuron projection terminus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

determination method

6 references

8 April 2019

Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

8 April 2019

Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

biological process

axon target recognition

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

eating behavior

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

axonal transport of mitochondrion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

response to ischemia

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

neuromuscular process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

negative regulation of MAP kinase activity

determination method

1 reference

8 April 2019

Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

sensory perception of pain

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

cell population proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

regulation of macroautophagy

determination method

1 reference

8 April 2019

UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

adult walking behavior

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

proteasome-mediated ubiquitin-dependent protein catabolic process

determination method

1 reference

8 April 2019

The role of oxidative stress in Parkinson's disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

protein deubiquitination

determination method

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09936&geneProductId=UniProtKB:P09936

determination method

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09936&geneProductId=UniProtKB:P09936

determination method

27 March 2018

Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09936&geneProductId=UniProtKB:P09936

determination method

protein deubiquitination

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

8 April 2019

Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09936

determination method

Gene Atlas image

PBB GE UCHL1 201387 s at fs.png
732 × 530; 11 KB

0 references

Peptidase C12, ubiquitin carboxyl-terminal hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P09936

Identifiers

MeSH descriptor ID

subject named as

Ubiquitin Thiolesterase

0 references

D08.811.037.500

0 references

D08.811.277.352.897.850

0 references

D12.776.637.937

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000422542

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000422542

ENSP00000284440

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000284440

ENSP00000423348

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000423348

ENSP00000423623

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000423623

ENSP00000425714

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000425714

ENSP00000426634

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000426634

ENSP00000426895

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000426895

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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