Antigen dose, type of antigen-presenting cell and time of differentiation contribute to the T helper 1/T helper 2 polarization of naive T cells (Q79316054)

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scientific article published on 01 December 2003

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English	Antigen dose, type of antigen-presenting cell and time of differentiation contribute to the T helper 1/T helper 2 polarization of naive T cells	scientific article published on 01 December 2003

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scholarly article

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21 December 2019

Antigen dose, type of antigen-presenting cell and time of differentiation contribute to the T helper 1/T helper 2 polarization of naive T cells (English)

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Europe PubMed Central

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21 December 2019

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T Rothoeft

1

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21 December 2019

A Gonschorek

2

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21 December 2019

H Bartz

3

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21 December 2019

O Anhenn

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21 December 2019

U Schauer

5

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21 December 2019

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1 December 2003

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21 December 2019

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21 December 2019

110

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21 December 2019

4

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21 December 2019

430-439

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21 December 2019

Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches

1 reference

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Small amounts of superantigen, when presented on dendritic cells, are sufficient to initiate T cell responses

1 reference

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21 January 2018

Three-dimensional segregation of supramolecular activation clusters in T cells

1 reference

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21 January 2018

The immunological synapse: a molecular machine controlling T cell activation

1 reference

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Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells

1 reference

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21 January 2018

Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells

1 reference

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21 January 2018

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model

1 reference

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21 January 2018

CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha

1 reference

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21 January 2018

Detection of intracellular cytokines by flow cytometry

1 reference

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21 January 2018

A new in vitro model for studying human T cell differentiation: T(H1)/T(H2) induction following activation by superantigens

1 reference

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21 January 2018

Accessory cell-T lymphocyte interactions. Antigen-dependent and -independent clustering

1 reference

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21 January 2018

An antigen-independent contact mechanism as an early step in T cell-proliferative responses to dendritic cells

1 reference

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21 January 2018

Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses

1 reference

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21 January 2018

Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2003.01758.X

21 January 2018

Role of ICAM-3 in the initial interaction of T lymphocytes and APCs

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2003.01758.X

21 January 2018

ICAM-3 interacts with LFA-1 and regulates the LFA-1/ICAM-1 cell adhesion pathway

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2003.01758.X

21 January 2018

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2003.01758.X

21 January 2018

Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes

1 reference

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21 January 2018

T cell receptor signaling precedes immunological synapse formation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2003.01758.X

21 January 2018

Antigen-dependent and -independent Ca2+ responses triggered in T cells by dendritic cells compared with B cells

1 reference

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21 January 2018

Differential roles of Lck and Itk in T cell response to antigen recognition revealed by calcium imaging and electron microscopy.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2003.01758.X

21 January 2018

Functional antigen-independent synapses formed between T cells and dendritic cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2003.01758.X

21 January 2018

Stimulation of naïve T-cell adhesion and immunological synapse formation by chemokine-dependent and -independent mechanisms

1 reference

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21 January 2018

NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2003.01758.X

21 January 2018

The physical association of protein kinase C theta with a lipid raft-associated inhibitor of kappa B factor kinase (IKK) complex plays a role in the activation of the NF-kappa B cascade by TCR and CD28.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2003.01758.X

21 January 2018

Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2003.01758.X

21 January 2018

CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2003.01758.X

21 January 2018

Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2003.01758.X

21 January 2018

T cell expressed PKCtheta demonstrates cell-type selective function

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2003.01758.X

21 January 2018

Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2003.01758.X

21 January 2018

JNK is involved in signal integration during costimulation of T lymphocytes.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2003.01758.X

21 January 2018

Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2003.01758.X

21 January 2018

Naive CD4+ T cells exhibit distinct expression patterns of cytokines and cell surface molecules on their primary responses to varying doses of antigen

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2003.01758.X

21 January 2018

Microbial Compounds Selectively Induce Th1 Cell-Promoting or Th2 Cell-Promoting Dendritic Cells In Vitro with Diverse Th Cell-Polarizing Signals

1 reference

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Cutting edge: bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization.

1 reference

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21 January 2018

The immunological synapse: the more you look the less you know...

1 reference

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12 December 2020

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Large-scale isolation of immature dendritic cells with features of Langerhans cells by sorting CD34+ cord blood stem cells cultured in the presence of TGF-beta1 for cutaneous leukocyte antigen (CLA).

1 reference

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12 December 2020

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Respiratory syncytial virus decreases the capacity of myeloid dendritic cells to induce interferon-gamma in naïve T cells

1 reference

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12 December 2020

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The specific direct interaction of helper T cells and antigen-presenting B cells. II. Reorientation of the microtubule organizing center and reorganization of the membrane-associated cytoskeleton inside the bound helper T cells

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of cytokines by immunofluorescence and the paraformaldehyde-saponin procedure

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting cell requirements

1 reference

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12 December 2020

based on heuristic

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Interleukin 4 production by CD4+ T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type

1 reference

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12 December 2020

based on heuristic

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Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines.

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polarization of IL-4- and IFN-gamma-producing CD4+ T cells following activation of naive CD4+ T cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14632640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The interplay between the duration of TCR and cytokine signaling determines T cell polarization

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low-affinity LFA-1/ICAM-3 interactions augment LFA-1/ICAM-1-mediated T cell adhesion and signaling by redistribution of LFA-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/14632640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of helper T cell responses to staphylococcal superantigens.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14632640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human dendritic cells require exogenous interleukin-12-inducing factors to direct the development of naive T-helper cells toward the Th1 phenotype.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14632640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/14632640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High antigen density and IL-2 are required for generation of CD4 effectors secreting Th1 rather than Th0 cytokines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14632640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase Ctheta, a selective upstream regulator of JNK/SAPK and IL-2 promoter activation in Jurkat T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14632640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptide dose, affinity, and time of differentiation can contribute to the Th1/Th2 cytokine balance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14632640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temporal sequence and functional implications of V beta-specific T cell receptor down-regulation and costimulatory molecule expression following in vitro stimulation with the staphylococcal superantigen Toxic shock syndrome toxin-1

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TSST-1 induces Th1 or Th2 differentiation in naïve CD4+ T cells in a dose- and APC-dependent manner.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14632640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2567.2003.01758.X

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14632640%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14632640%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

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