Activation of c-Jun NH2-terminal kinase (JNK) pathway during islet transplantation and prevention of islet graft loss by intraportal injection of JNK inhibitor (Q79563979)

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scientific article published on 16 January 2007

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English	Activation of c-Jun NH2-terminal kinase (JNK) pathway during islet transplantation and prevention of islet graft loss by intraportal injection of JNK inhibitor	scientific article published on 16 January 2007

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24 December 2019

Activation of c-Jun NH2-terminal kinase (JNK) pathway during islet transplantation and prevention of islet graft loss by intraportal injection of JNK inhibitor (English)

1 reference

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24 December 2019

Hirofumi Noguchi

1

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24 December 2019

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Y Nakai

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24 December 2019

M Ueda

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24 December 2019

Y Masui

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S Futaki

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24 December 2019

N Kobayashi

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24 December 2019

S Hayashi

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24 December 2019

S Matsumoto

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24 December 2019

publication date

16 January 2007

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3

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24 December 2019

612-619

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24 December 2019

https://scigraph.springernature.com/pub.10.1007/s00125-006-0563-2

0 references

Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

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Proapoptotic Bax is hyperexpressed in isolated human islets compared with antiapoptotic Bcl-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BETA2/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of cytokine mRNA expression in syngeneic islet grafts of NOD mice: interleukin 2 and interferon gamma mRNA expression correlate with graft rejection and interleukin 10 with graft survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin independence after living-donor distal pancreatectomy and islet allotransplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A central role for JNK in obesity and insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IB1 reduces cytokine-induced apoptosis of insulin-secreting cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new cell-permeable peptide allows successful allogeneic islet transplantation in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Controlled expansion of human endothelial cell populations by Cre-loxP-based reversible immortalization.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo protein transduction: delivery of a biologically active protein into the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of 15-deoxyspergualin on immediate function and long-term survival of transplanted islets in murine recipients of a marginal islet mass

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heme oxygenase-1 fused to a TAT peptide transduces and protects pancreatic beta-cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell loss in isolated human islets occurs by apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and activation of recombinant p38 isoforms alpha, beta, gamma, and delta

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular Stress Signaling Pathways Activated During Human Islet Preparation and Following Acute Cytokine Exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic islets activate portal vein endothelial cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vulnerability of Islets in the Immediate Posttransplantation Period: Dynamic Changes in Structure and Function

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction by the c-Jun N-terminal kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary nonfunction of islet grafts in autoimmune diabetic nonobese diabetic mice is prevented by treatment with interleukin-4 and interleukin-10

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection of islets by in situ peptide-mediated transduction of the Ikappa B kinase inhibitor Nemo-binding domain peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intercellular trafficking and protein delivery by a herpesvirus structural protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PDX-1 protein is internalized by lipid raft-dependent macropinocytosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A tripartite anoikis-like mechanism causes early isolated islet apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of islet transplantation from non-heart beating donors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of nitric oxide in IL-1 beta-mediated dysfunction of rodent islets of Langerhans. Implications for the function of intrahepatic islet grafts

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting JNK for therapeutic benefit: from junk to gold?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The interaction between primate blood and mouse islets induces accelerated clotting with islet destruction

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell permeable peptide of JNK inhibitor prevents islet apoptosis immediately after isolation and improves islet graft function

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of primary islet isograft nonfunction in mice with pravastatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human pancreatic islets transfected to produce an inhibitor of TNF are protected against destruction by human leukocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delivery of Bcl-XL or its BH4 domain by protein transduction inhibits apoptosis in human islets.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteins linked to a protein transduction domain efficiently transduce pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/17225125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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