Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-beta-D-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6 (Q79791354)
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scientific article published on 01 March 2004
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-beta-D-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6 |
scientific article published on 01 March 2004 |
Statements
Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-beta-D-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with curative antitumor activity against prostate carcinoma xenograft tumor model (English)
Balu N Balasubramanian
Denis R St Laurent
Mark G Saulnier
Byron H Long
Carol Bachand
Francis Beaulieu
Wendy Clarke
Milind Deshpande
Jeffrey Eummer
Craig R Fairchild
David B Frennesson
Robert Kramer
Frank Y Lee
Mikael Mahler
Alain Martel
B Narasimhulu Naidu
William C Rose
John Russell
Edward Ruediger
Carola Solomon
Karen M Stoffan
Henry Wong
John J Wright
Kurt Zimmermann
Dolatrai M Vyas