X-C motif chemokine ligand 1 (Q8041718)

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mammalian protein found in Homo sapiens

c motif chemokine 1
lymphotactin
small inducible cytokine subfamily C, member 1 (lymphotactin)
single cysteine motif 1a
XC chemokine ligand 1
cytokine SCM-1
ATAC
SCM-1-alpha
XCL1
small-inducible cytokine C1
lymphotaxin
chemokine (C motif) ligand 1

Language	Label	Description	Also known as
English	X-C motif chemokine ligand 1	mammalian protein found in Homo sapiens	c motif chemokine 1 lymphotactin small inducible cytokine subfamily C, member 1 (lymphotactin) single cysteine motif 1a XC chemokine ligand 1 cytokine SCM-1 ATAC SCM-1-alpha XCL1 small-inducible cytokine C1 lymphotaxin chemokine (C motif) ligand 1

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P47992

Chemokine interleukin-8-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P47992

Chemokine interleukin-8-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

cytokine activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

Structural rearrangement of human lymphotactin, a C chemokine, under physiological solution conditions

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

CCR chemokine receptor binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

protein binding

determination method

1 reference

8 April 2019

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

chemokine activity

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

8 April 2019

Molecular cloning and functional characterization of human lymphotactin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

extracellular space

determination method

3 references

biological process

cellular response to transforming growth factor beta stimulus

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

cellular response to interleukin-4

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

release of sequestered calcium ion into cytosol

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

negative regulation of interferon-gamma production

determination method

1 reference

8 April 2019

The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

positive regulation of T-helper 1 cell cytokine production

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

monocyte chemotaxis

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

positive regulation of interleukin-10 production

determination method

1 reference

8 April 2019

XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

positive regulation of natural killer cell chemotaxis

determination method

1 reference

8 April 2019

Lymphotactin is produced by NK cells and attracts both NK cells and T cells in vivo

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

chemokine-mediated signaling pathway

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

positive regulation of CD4-positive, alpha-beta T cell proliferation

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

cellular response to tumor necrosis factor

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

cell-cell signaling

determination method

1 reference

8 April 2019

Molecular cloning and functional characterization of human lymphotactin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

positive regulation of thymocyte migration

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

response to virus

determination method

1 reference

8 April 2019

Induction of C chemokine XCL1 (lymphotactin/single C motif-1 alpha/activation-induced, T cell-derived and chemokine-related cytokine) expression by HIV-1 Tat protein

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

positive regulation of T cell mediated cytotoxicity

determination method

1 reference

8 April 2019

XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

positive regulation of release of sequestered calcium ion into cytosol

determination method

1 reference

8 April 2019

Molecular cloning and functional characterization of human lymphotactin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

negative regulation of T-helper 1 type immune response

determination method

1 reference

8 April 2019

The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

negative regulation of DNA-binding transcription factor activity

determination method

1 reference

8 April 2019

The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

neutrophil chemotaxis

determination method

1 reference

16 July 2018

Structural rearrangement of human lymphotactin, a C chemokine, under physiological solution conditions

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47992&geneProductId=UniProtKB:P47992

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

positive regulation of leukocyte chemotaxis

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

positive regulation of GTPase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

positive regulation of granzyme A production

determination method

1 reference

8 April 2019

XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

positive regulation of immunoglobulin production in mucosal tissue

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

negative regulation of T cell cytokine production

determination method

1 reference

8 April 2019

The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

positive regulation of T cell cytokine production

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

cellular response to interleukin-1

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

positive regulation of T cell chemotaxis

determination method

1 reference

16 July 2018

Molecular cloning and functional characterization of human lymphotactin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47992&geneProductId=UniProtKB:P47992

determination method

mature natural killer cell chemotaxis

determination method

1 reference

8 April 2019

Lymphotactin is produced by NK cells and attracts both NK cells and T cells in vivo

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

regulation of inflammatory response

determination method

1 reference

8 April 2019

XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

positive regulation of ERK1 and ERK2 cascade

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

positive regulation of neutrophil chemotaxis

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

cellular response to interferon-gamma

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

immune response

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

positive regulation of B cell chemotaxis

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

positive regulation of transforming growth factor beta production

determination method

1 reference

8 April 2019

XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

negative regulation of CD4-positive, alpha-beta T cell proliferation

determination method

1 reference

8 April 2019

The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

positive regulation of T-helper 2 cell cytokine production

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

positive regulation of CD8-positive, alpha-beta T cell proliferation

determination method

1 reference

8 April 2019

The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

negative regulation of interleukin-2 production

determination method

1 reference

8 April 2019

The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

negative regulation of T-helper 1 cell activation

determination method

1 reference

8 April 2019

The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

positive regulation of granzyme B production

determination method

1 reference

8 April 2019

XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

signal transduction

determination method

1 reference

8 April 2019

Identification of single C motif-1/lymphotactin receptor XCR1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

antimicrobial humoral immune response mediated by antimicrobial peptide

determination method

1 reference

5 June 2018

Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47992&geneProductId=UniProtKB:P47992

determination method

regulation of signaling receptor activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

inflammatory response

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

lymphocyte chemotaxis

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47992

determination method

Gene Atlas image

PBB GE XCR1 221468 at fs.png
732 × 530; 11 KB

0 references

Chemokine interleukin-8-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P47992

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000356792

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000356792

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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