Naphthyl tetronic acids as multi-target inhibitors of bacterial peptidoglycan biosynthesis (Q80546533)

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1 January 2020

title

Naphthyl tetronic acids as multi-target inhibitors of bacterial peptidoglycan biosynthesis (English)

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author name string

Tarek S Mansour

1

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1 January 2020

Craig E Caufield

2

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1 January 2020

Beth Rasmussen

3

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Rajiv Chopra

4

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1 January 2020

Girija Krishnamurthy

5

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1 January 2020

Koi M Morris

6

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Kristine Svenson

7

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Joel Bard

8

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Claudia Smeltzer

9

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Shaughnessy Naughton

10

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Schuyler Antane

11

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1 January 2020

Youjun Yang

12

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1 January 2020

Anatoly Severin

13

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1 January 2020

Dominick Quagliato

14

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Peter J Petersen

15

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1 January 2020

Guy Singh

16

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publication date

1 October 2007

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1 January 2020

volume

2

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issue

10

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page(s)

1414-1417

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Why is big Pharma getting out of antibacterial drug discovery?

1 January 2020

cites work

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7 January 2021

Drugs for bad bugs: confronting the challenges of antibacterial discovery

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7 January 2021

Structure and function of the Mur enzymes: development of novel inhibitors

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Autolysis control hypotheses for tolerance to wall antibiotics

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7 January 2021

Genome-wide transcriptional profiling of the response of Staphylococcus aureus to cell-wall-active antibiotics reveals a cell-wall-stress stimulon

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7 January 2021

Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA.

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7 January 2021

A novel inhibitor that suspends the induced fit mechanism of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA).

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7 January 2021

UDP-N-acetylmuramic acid (UDP-MurNAc) is a potent inhibitor of MurA (enolpyruvyl-UDP-GlcNAc synthase).

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7 January 2021

Discovery of the first antibacterial small molecule inhibitors of MurB.

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7 January 2021

4-Thiazolidinones: novel inhibitors of the bacterial enzyme MurB

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7 January 2021

2-Phenyl-5,6-dihydro-2H-thieno[3,2-c]pyrazol-3-ol derivatives as new inhibitors of bacterial cell wall biosynthesis

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Biochemical characterization of a phosphinate inhibitor of Escherichia coli MurC.

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A new approach towards peptidosulfonamides: synthesis of potential inhibitors of bacterial peptidoglycan biosynthesis enzymes MurD and MurE

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Structure-based optimization of MurF inhibitors.

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7 January 2021

4-Substituted D-glutamic acid analogues: the first potent inhibitors of glutamate racemase (MurI) enzyme with antibacterial activity

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7 January 2021

Molecular modeling and bioinformatical analysis of the antibacterial target enzyme MurA from a drug design perspective

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7 January 2021

Structure-based design approaches to cell wall biosynthesis inhibitors

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7 January 2021

An ultraefficient affinity-based high-throughout screening process: application to bacterial cell wall biosynthesis enzyme MurF.

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7 January 2021

Development of an LC-MS based enzyme activity assay for MurC: application to evaluation of inhibitors and kinetic analysis

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7 January 2021

Combinatorial enzymatic assay for the screening of a new class of bacterial cell wall inhibitors

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7 January 2021

Utility of muropeptide ligase for identification of inhibitors of the cell wall biosynthesis enzyme MurF.

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7 January 2021

Preparation of potential inhibitors of the mur-pathway enzymes on solid support using an acetal linker

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7 January 2021

3,5-dioxopyrazolidines, novel inhibitors of UDP-N- acetylenolpyruvylglucosamine reductase (MurB) with activity against gram-positive bacteria

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7 January 2021

Pulvinones as bacterial cell wall biosynthesis inhibitors

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7 January 2021

Multi-targeting by monotherapeutic antibacterials.

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7 January 2021

Synthesis of (E)- and (Z)-pulvinones

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7 January 2021

Domino syntheses of bioactive tetronic and tetramic acids

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7 January 2021

Identifiers

DOI

10.1002/CMDC.200700094

1 reference

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1 January 2020

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