Claudin 4 identifies a wide spectrum of epithelial neoplasms and represents a very useful marker for carcinoma versus mesothelioma diagnosis in pleural and peritoneal biopsies and effusions (Q80565374)

From Wikidata

Jump to navigation Jump to search

scientific article published on 03 July 2007

Language	Label	Description	Also known as
English	Claudin 4 identifies a wide spectrum of epithelial neoplasms and represents a very useful marker for carcinoma versus mesothelioma diagnosis in pleural and peritoneal biopsies and effusions	scientific article published on 03 July 2007

Statements

scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609977%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Claudin 4 identifies a wide spectrum of epithelial neoplasms and represents a very useful marker for carcinoma versus mesothelioma diagnosis in pleural and peritoneal biopsies and effusions (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609977%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Fabio Facchetti

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609977%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

author name string

Silvia Lonardi

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609977%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Francesca Gentili

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609977%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Luisa Bercich

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609977%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Marcella Falchetti

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609977%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Regina Tardanico

6

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609977%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Carla Baronchelli

7

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609977%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Laura Lucini

8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609977%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Alessandro Santin

9

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609977%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Bruno Murer

10

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609977%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

publication date

3 July 2007

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609977%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Virchows Archiv

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609977%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

451

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609977%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609977%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

669-680

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609977%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

https://scigraph.springernature.com/pub.10.1007/s00428-007-0448-x

0 references

The Immunohistochemical Diagnostic Panel for Epithelial Mesothelioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Claudin-4, mitogen-activated protein kinase kinase 4, and stratifin are markers of gastric adenocarcinoma precursor lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Claudins 1, 3, 4 and 5 in gastric carcinoma, loss of claudin expression associates with the diffuse subtype

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sarcomatoid mesothelioma and its histological mimics: a comparative immunohistochemical study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Applications and limitations of immunohistochemistry in the diagnosis of malignant mesothelioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-mesothelial markers in sarcomatoid mesothelioma and other spindle cell neoplasms

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical diagnosis of epithelioid mesothelioma: an update

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of 12 antibodies for distinguishing epithelioid mesothelioma from adenocarcinoma: identification of a three-antibody immunohistochemical panel with maximal sensitivity and specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

E-cadherin, N-cadherin, and calretinin in pleural effusions: the good, the bad, the worthless

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of claudin proteins in esophageal adenocarcinoma and its precursor lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative immunohistochemical study of primary and metastatic carcinomas of the liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calretinin immunostaining in benign and malignant pleural effusions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemistry in the distinction between malignant mesothelioma and pulmonary adenocarcinoma: a critical evaluation of new antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The diagnostic utility of immunohistochemistry in distinguishing between mesothelioma and renal cell carcinoma: a comparative study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The immunohistochemical diagnosis of mesothelioma: a comparative study of epithelioid mesothelioma and lung adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical diagnosis of epithelioid mesotheliomas: a critical review of old markers, new markers

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Claudin-4 expression decreases invasiveness and metastatic potential of pancreatic cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathological recognition of diffuse malignant mesothelioma of the pleura: the significance of the historical perspective as regards this signal tumor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: identification of candidate molecular markers for ovarian cancer diagnosis and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An immunohistochemical analysis of 13 cases with combined hepatocellular and cholangiocellular carcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison of CD10 to pCEA, MOC-31, and hepatocyte for the distinction of malignant tumors in the liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The diagnostic utility of immunohistochemistry and electron microscopy in distinguishing between peritoneal mesotheliomas and serous carcinomas: a comparative study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Malignant peritoneal mesothelioma in women: a study of 75 cases with emphasis on their morphologic spectrum and differential diagnosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The diagnostic utility of MOC31, BerEP4, RCC marker and CD10 in the classification of renal cell carcinoma and renal oncocytoma: an immunohistochemical analysis of 328 cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The diagnostic utility of immunohistochemistry in distinguishing between epithelioid mesotheliomas and squamous carcinomas of the lung: a comparative study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Claudins in differential diagnosis between mesothelioma and metastatic adenocarcinoma of the pleura

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down-regulation of the claudin-18 gene, identified through serial analysis of gene expression data analysis, in gastric cancer with an intestinal phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MOC-31 aids in the differentiation of metastatic adenocarcinoma from hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Claudin expression in gastric adenocarcinomas: a tissue microarray study with prognostic correlation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Claudin-4: a new target for pancreatic cancer treatment using Clostridium perfringens enterotoxin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of a panel of markers in the differential diagnosis of adenocarcinoma and reactive mesothelial cells in fluid cytology

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tight junction-associated proteins (occludin, ZO-1, claudin-1, claudin-4) in squamous cell carcinoma and Bowen's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical analysis still has a limited role in the diagnosis of malignant mesothelioma. A study of thirteen antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in prostate cancer epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Value of immunohistochemistry in distinguishing peritoneal mesothelioma from serous carcinoma of the ovary and peritoneum: a review and update

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The high post-test probability of a cytological examination renders further investigations to establish a diagnosis of epithelial malignant pleural mesothelioma redundant.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Claudins 2, 3, 4, and 5 in Paget's disease and breast carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The diagnosis of malignancy in effusion cytology: a pattern recognition approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Value of mesothelial and epithelial antibodies in distinguishing diffuse peritoneal mesothelioma in females from serous papillary carcinoma of the ovary and peritoneum

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitivity and specificity of immunohistochemical markers used in the diagnosis of epithelioid mesothelioma: a detailed systematic analysis using published data

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The claudin gene family: expression in normal and neoplastic tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor receptor expression in follicular dendritic cells: a shared feature of follicular dendritic cell sarcoma and Castleman’s disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of claudins 1, 4, 5, and 7 in ovarian tumors of diverse types

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clostridium perfringens enterotoxin elicits rapid and specific cytolysis of breast carcinoma cells mediated through tight junction proteins claudin 3 and 4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical analysis of peritoneal mesothelioma and primary and secondary serous carcinoma of the peritoneum: antibodies to estrogen and progesterone receptors are useful

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical analysis of hepatocellular and adenocarcinoma in the liver: MOC31 compares favorably with other putative markers

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Value of estrogen and progesterone receptor immunostaining in distinguishing between peritoneal mesotheliomas and serous carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Claudin proteins in human cancer: promising new targets for diagnosis and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Claudin-4 differentiates biliary tract cancers from hepatocellular carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactivity of B72.3 with adenocarcinomas. An immunohistochemical study of 476 cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Malignant mesothelioma in 2004: How advanced technology and new drugs are changing the perspectives of mesothelioma patients. Highlights from the VIIth Meeting of the International Mesothelioma Interest Group.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

What are the current best immunohistochemical markers for the diagnosis of epithelioid mesothelioma? A review and update

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential gene expression profiles between tumor biopsies and short-term primary cultures of ovarian serous carcinomas: Identification of novel molecular biomarkers for early diagnosis and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of chemotherapy-resistant human ovarian cancer xenografts in C.B-17/SCID mice by intraperitoneal administration of Clostridium perfringens enterotoxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

D2-40 is not a specific marker for cells of mesothelial origin in serous effusions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular architecture of tight junctions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of claudins 1, 2, 3, 4, 5 and 7 in various types of tumours

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression profiling identifies genes associated with invasive intraductal papillary mucinous neoplasms of the pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression signatures differentiate ovarian/peritoneal serous carcinoma from diffuse malignant peritoneal mesothelioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Claudins upregulation in human colorectal cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression signatures and biomarkers of noninvasive and invasive breast cancer cells: comprehensive profiles by representational difference analysis, microarrays and proteomics

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunocytochemical panel for distinguishing between carcinoma and reactive mesothelial cells in body cavity fluids

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Malignant vascular tumors of the serous membranes mimicking mesothelioma. A report of 14 cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HepPar1, MOC-31, pCEA, mCEA and CD10 for distinguishing hepatocellular carcinoma vs. metastatic adenocarcinoma in liver fine needle aspirates

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aldosterone and tight junctions: modulation of claudin-4 phosphorylation in renal collecting duct cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression fingerprint of uterine serous papillary carcinoma: identification of novel molecular markers for uterine serous cancer diagnosis and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crucial roles of Sp1 and epigenetic modifications in the regulation of the CLDN4 promoter in ovarian cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunocytochemistry in the differential diagnosis of serous effusions: a comparative evaluation of eight monoclonal antibodies in Papanicolaou stained smears

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences in expression patterns of the tight junction proteins,claudin 1, 3, 4 and 5, in human ovarian surface epithelium as compared to epithelia in inclusion cysts and epithelial ovarian tumours.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17609977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00428-007-0448-X

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609977%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609977%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q80565374&oldid=1779950124"