Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture (Q80600027)

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2 January 2020

title

Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture (English)

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2 January 2020

5

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2 January 2020

author name string

Zhaodong Li

1

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2 January 2020

Jonathan A Dranoff

2

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2 January 2020

Erick P Chan

3

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2 January 2020

Masayuki Uemura

4

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2 January 2020

Rebecca G Wells

6

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2 January 2020

language of work or name

English

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publication date

1 October 2007

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2 January 2020

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2 January 2020

volume

46

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2 January 2020

issue

4

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2 January 2020

page(s)

1246-1256

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2 January 2020

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Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury

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Role of mesenchymal cell populations in porcine serum-induced rat liver fibrosis

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Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: distinct roles of (myo-)fibroblast subpopulations in hepatic tissue repair

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Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential

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Cellular retinol-binding protein-1 expression in normal and fibrotic/cirrhotic human liver: different patterns of expression in hepatic stellate cells and (myo)fibroblast subpopulations

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A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations.

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The bone marrow functionally contributes to liver fibrosis.

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Prominent contribution of portal mesenchymal cells to liver fibrosis in ischemic and obstructive cholestatic injuries.

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Phenotypic change in portal fibroblasts in biliary fibrosis

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Peribiliary myofibroblasts in biliary type liver fibrosis

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Cellular sources of matrix proteins in experimentally induced cholestatic rat liver

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Cellular retinol-binding protein-1 expression and modulation during in vivo and in vitro myofibroblastic differentiation of rat hepatic stellate cells and portal fibroblasts

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The ecto-nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver

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Isolation of primary rat liver fibroblasts

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Secretion of MCP-1/CCL2 by bile duct epithelia induces myofibroblastic transdifferentiation of portal fibroblasts

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Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization

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Autocrine release of TGF-beta by portal fibroblasts regulates cell growth

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Cell locomotion and focal adhesions are regulated by substrate flexibility

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Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion

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Matrices with compliance comparable to that of brain tissue select neuronal over glial growth in mixed cortical cultures

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Cell type-specific response to growth on soft materials

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Tissue cells feel and respond to the stiffness of their substrate

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The compliance of collagen gels regulates transforming growth factor-beta induction of alpha-smooth muscle actin in fibroblasts

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The C-terminal cysteine-rich region dictates specific catalytic properties in chimeras of the ectonucleotidases NTPDase1 and NTPDase2.

1 reference

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Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation

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Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta ) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent.

1 reference

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Neurite branching on deformable substrates

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Expression and cellular localization of fibrillin-1 in normal and pathological human liver

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Elastin in human, baboon, and mouse liver: An immunohistochemical and immunoelectron microscopic study

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Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis

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Fibrillin-1 expression in normal and fibrotic rat liver and in cultured hepatic fibroblastic cells: modulation by mechanical stress and role in cell adhesion.

1 reference

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Tropoelastin expression is up-regulated during activation of hepatic stellate cells and in the livers of CCl(4)-cirrhotic rats

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7 January 2021

The role of matrix stiffness in hepatic stellate cell activation and liver fibrosis

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7 January 2021

Anti-TGF-beta strategies for the treatment of chronic liver disease

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The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo

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The role of Smad3 in mediating mouse hepatic stellate cell activation

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Dominant-negative soluble PDGF-beta receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis

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Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice

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The role of integrin-linked kinase in liver wound healing.

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Involvement of integrin-linked kinase in carbon tetrachloride-induced hepatic fibrosis in rats

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7 January 2021

Identifiers

DOI

10.1002/HEP.21792

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17625791%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

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