The CXCL12-CXCR4 chemotactic pathway as a target of adjuvant breast cancer therapies (Q80937679)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15516962%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

review article

1 reference

title

The CXCL12-CXCR4 chemotactic pathway as a target of adjuvant breast cancer therapies (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15516962%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1 reference

1 reference

Richard J Epstein

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15516962%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

publication date

1 November 2004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15516962%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

published in

Nature Reviews Cancer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15516962%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

volume

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15516962%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15516962%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

page(s)

901-909

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15516962%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrc1473

4 January 2020

exact match

0 references

cites work

The CMF program for operable breast cancer with positive axillary nodes:Updated analysis on the disease-free interval, site of relapse and drug tolerance

1 reference

Beneficial effect of adjuvant tamoxifen therapy in primary breast cancer patients with high oestrogen receptor values

31 March 2020

1 reference

Failure of chemotherapy to prolong survival in a group of patients with metastatic breast cancer

31 March 2020

1 reference

Gonadal damage from chemotherapy and radiotherapy

31 March 2020

1 reference

Endocrine profile in breast cancer patients receiving chemotherapy

31 March 2020

1 reference

Mechanism of action of adjuvant chemotherapy in early breast cancer

31 March 2020

1 reference

Prognostic effect of amenorrhoea and elevated serum gonadotropin levels induced by adjuvant chemotherapy in premenopausal node-positive breast cancer patients

31 March 2020

1 reference

The magnitude of endocrine effects of adjuvant chemotherapy for premenopausal breast cancer patients. The International Breast Cancer Study Group.

31 March 2020

1 reference

Dose and dose intensity as determinants of outcome in the adjuvant treatment of breast cancer. The Cancer and Leukemia Group B

31 March 2020

1 reference

Long term follow-up of women treated with 16-week, dose-intensive adjuvant chemotherapy for high risk breast carcinoma

31 March 2020

1 reference

Lack of effect of adjuvant chemotherapy on the elimination of single dormant tumor cells in bone marrow of high-risk breast cancer patients

31 March 2020

1 reference

Impact of neutropenia on delivering planned adjuvant chemotherapy: UK audit of primary breast cancer patients

31 March 2020

1 reference

Moderate neutropenia with adjuvant CMF confers improved survival in early breast cancer

31 March 2020

1 reference

Dose-dense anthracycline-based chemotherapy for node-positive breast cancer

31 March 2020

1 reference

Randomized Trial of Dose-Dense Versus Conventionally Scheduled and Sequential Versus Concurrent Combination Chemotherapy as Postoperative Adjuvant Treatment of Node-Positive Primary Breast Cancer: First Report of Intergroup Trial C9741/Cancer and Leu

31 March 2020

1 reference

Serum cytokine level fluctuations in chemotherapy-induced myelosuppression

31 March 2020

1 reference

Neutrophil adhesion molecules in colorectal surgery: effect of filgrastim given perioperatively

31 March 2020

1 reference

Proliferative and migratory responses of murine microvascular endothelial cells to granulocyte-colony-stimulating factor

31 March 2020

1 reference

Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment

31 March 2020

1 reference

Proteolytic cleavage of granulocyte colony‐stimulating factor and its receptor by neutrophil elastase induces growth inhibition and decreased cell surface expression of the granulocyte colony‐stimulating factor receptor

31 March 2020

1 reference

Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor.

31 March 2020

1 reference

Mobilization of myeloma cells involves SDF-1/CXCR4 signaling and downregulation of VLA-4.

31 March 2020

1 reference

Dipeptidyl peptidase IV (DPPIV) inhibits cellular invasion of melanoma cells.

31 March 2020

1 reference

Functional expression of the C-X-C chemokine receptor CXCR4 by human bronchial epithelial cells: regulation by proinflammatory mediators

31 March 2020

1 reference

NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4

31 March 2020

1 reference

Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas.

31 March 2020

1 reference

Chemokines: multiple levels of leukocyte migration control.

31 March 2020

1 reference

Proteoglycans on bone marrow endothelial cells bind and present SDF-1 towards hematopoietic progenitor cells

31 March 2020

1 reference

Synergy between proinflammatory ligands of G protein-coupled receptors in neutrophil activation and migration.

31 March 2020

1 reference

Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis.

31 March 2020

1 reference

Stromal cell-derived factor 1 alpha-induced chemotaxis in T cells is mediated by nitric oxide signaling pathways

31 March 2020

1 reference

The chemokine receptor CXCR4 enhances integrin-mediated in vitro adhesion and facilitates engraftment of leukemic precursor-B cells in the bone marrow.

31 March 2020

1 reference

Hormonal and embryonic regulation of chemokine receptors CXCR1, CXCR4, CCR5 and CCR2B in the human endometrium and the human blastocyst

31 March 2020

1 reference

Stromal cell-derived factor-1alpha promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities.

31 March 2020

1 reference

Comodulation of CXCR4 and CD26 in human lymphocytes

31 March 2020

1 reference

Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells

31 March 2020

1 reference

CXCR4 is expressed in ductal carcinoma in situ of the breast and in atypical ductal hyperplasia.

31 March 2020

1 reference

Cell surface peptidase CD26/DPPIV mediates G-CSF mobilization of mouse progenitor cells

31 March 2020

1 reference

Plasma levels of SDF-1 and expression of SDF-1 receptor on CD34+ cells in mobilized peripheral blood of non-Hodgkin's lymphoma patients

31 March 2020

1 reference

Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide

31 March 2020

1 reference

Cytokine gene expression in regenerating haematopoietic tissues of mice after cyclophosphamide treatment

31 March 2020

1 reference

Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells

31 March 2020

1 reference

The SDF-1-CXCR4 axis stimulates VEGF secretion and activates integrins but does not affect proliferation and survival in lymphohematopoietic cells.

31 March 2020

1 reference

Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic study

31 March 2020

1 reference

Hypoxia-induced production of stromal cell-derived factor 1 (CXCL12) and vascular endothelial growth factor by synovial fibroblasts

31 March 2020

1 reference

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

31 March 2020

1 reference

Stromal cell-derived factor-1alpha induces tube-like structure formation of endothelial cells through phosphoinositide 3-kinase

31 March 2020

1 reference

Endothelial cells differentially express functional CXC-chemokine receptor-4 (CXCR-4/fusin) under the control of autocrine activity and exogenous cytokines.

31 March 2020

1 reference

Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.

31 March 2020

1 reference

The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases

31 March 2020

1 reference

Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells.

31 March 2020

1 reference

CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion.

31 March 2020

1 reference

Involvement of chemokine receptors in breast cancer metastasis

31 March 2020

1 reference

Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma

31 March 2020

1 reference

Role of CXCR4 and SDF-1 in Mammary Tumor Metastasis in the Cat

31 March 2020

1 reference

Morphologic and quantitative changes in blood and marrow cells following growth factor therapy

31 March 2020

1 reference

Antiapoptotic effect of granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and cyclic AMP on human neutrophils: protein synthesis-dependent and protein synthesis-independent mechanisms and the role of the Janus

31 March 2020

1 reference

G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4.

31 March 2020

1 reference

Granulocyte colony-stimulating factor inhibits the mitochondria-dependent activation of caspase-3 in neutrophils

31 March 2020

1 reference

Mouse bone marrow contains large numbers of functionally competent neutrophils

31 March 2020

1 reference

Irradiation enhances the support of haemopoietic cell transmigration, proliferation and differentiation by endothelial cells.

31 March 2020

1 reference

Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function

31 March 2020

1 reference

Low-intensity conditioning is sufficient to ensure engraftment in matched unrelated bone marrow transplantation

31 March 2020

1 reference

Dose-reduced conditioning for allogeneic blood stem cell transplantation: durable engraftment without antithymocyte globulin

31 March 2020

1 reference

A delay in bone marrow transplantation after partial conditioning improves engraftment

31 March 2020

1 reference

Mobilisation kinetics of primitive haemopoietic cells following G-CSF with or without chemotherapy for advanced breast cancer

31 March 2020

1 reference

Homing and mobilization of hematopoietic stem cells and hematopoietic cancer cells are mirror image processes, utilizing similar signaling pathways and occurring concurrently: circulating cancer cells constitute an ideal target for concurrent treatm

31 March 2020

1 reference

Ex vivo treatment of proliferating human cord blood stem cells with stroma-derived factor-1 enhances their ability to engraft NOD/SCID mice

31 March 2020

1 reference

Treatment of circulating CD34(+) cells with SDF-1alpha or anti-CXCR4 antibody enhances migration and NOD/SCID repopulating potential

31 March 2020

1 reference

Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and Gαi proteins and enhances engraftment of competitive, repopulating stem cells

31 March 2020

1 reference

Overexpression of CXCR4 on human CD34+ progenitors increases their proliferation, migration, and NOD/SCID repopulation

31 March 2020

1 reference

Modulation of hematopoietic stem cell homing and engraftment by CD26

31 March 2020

1 reference

Circulating tumor cells, disease progression, and survival in metastatic breast cancer

31 March 2020

1 reference

Occult tumor contamination of hematopoietic stem-cell products does not affect clinical outcome of autologous transplantation in patients with metastatic breast cancer

31 March 2020

1 reference

Correlation between vascular endothelial growth factor, angiogenesis, and tumor-associated macrophages in invasive ductal breast carcinoma

31 March 2020

1 reference

Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells

31 March 2020

1 reference

Global analysis of ligand sensitivity of estrogen inducible and suppressible genes in MCF7/BUS breast cancer cells by DNA microarray

31 March 2020

1 reference

Estrogen receptors and distinct patterns of breast cancer relapse

31 March 2020

1 reference

Identifying breast cancer patients at high risk for bone metastases

31 March 2020

1 reference

Combination goserelin and tamoxifen therapy in premenopausal advanced breast cancer: a multicentre study by the ITMO group. Italian Trials in Medical Oncology

31 March 2020

1 reference

Adjuvant CMF effect on site of first recurrence, and appropriate follow-up intervals, in operable breast cancer with positive axillary nodes

31 March 2020

1 reference

Goserelin, a depot gonadotrophin-releasing hormone agonist in the treatment of premenopausal patients with metastatic breast cancer. German Zoladex Trial Group

31 March 2020

1 reference

The use of antiestrogens tamoxifen and nafoxidine in the treatment of human breast cancer in correlation with estrogen receptor values.A phase II study

31 March 2020

1 reference

LHRH-Agonist treatment in clinical and experimental human breast cancer

31 March 2020

1 reference

Relationship between steroid receptors (as continuous variables) and response to adjuvant treatments in postmenopausal women with node-positive breast cancer

31 March 2020

1 reference

Aromatase inhibition in the treatment of advanced breast cancer: is there a relationship between potency and clinical efficacy?

31 March 2020

1 reference

Neoadjuvant comparisons of aromatase inhibitors and tamoxifen: pretreatment determinants of response and on-treatment effect

31 March 2020

1 reference

Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer

31 March 2020

1 reference

Her-2/neu overexpression and response to oophorectomy plus tamoxifen adjuvant therapy in estrogen receptor-positive premenopausal women with operable breast cancer

31 March 2020

1 reference

31 March 2020

An attack on cytologism

1 reference

What does "response" in cancer chemotherapy really mean?

31 March 2020

1 reference

Chemokines, chemokine receptors and small-molecule antagonists: recent developments

31 March 2020

1 reference

Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4.

31 March 2020

1 reference

Endocrine/paracrine/autocrine survival factor activity of bone microenvironment participates in the development of androgen ablation and chemotherapy refractoriness of prostate cancer metastasis in skeleton.

31 March 2020

1 reference

Stromal extracellular matrix reduces chemotherapy-induced apoptosis in colon cancer cell lines

31 March 2020

1 reference

Bone marrow stromal cells regulate caspase 3 activity in leukemic cells during chemotherapy

31 March 2020

1 reference

Bevacizumab: an angiogenesis inhibitor with efficacy in colorectal and other malignancies

31 March 2020

1 reference

Inhibition of breast cancer metastasis by selective synthetic polypeptide against CXCR4.

31 March 2020

1 reference

T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer

31 March 2020

1 reference

p53 has a direct apoptogenic role at the mitochondria

31 March 2020

1 reference

In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation

31 March 2020

1 reference

Effects of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer. An overview of 61 randomized trials among 28,896 women.

31 March 2020

1 reference