Toward Mycobacterium tuberculosis DXR inhibitor design: homology modeling and molecular dynamics simulations (Q81305424)

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7 January 2020

title

Toward Mycobacterium tuberculosis DXR inhibitor design: homology modeling and molecular dynamics simulations (English)

1 reference

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Mycobacterium tuberculosis

7 January 2020

main subject

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Nidhi Singh

1

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7 January 2020

Mitchell A Avery

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17874041%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Christopher R McCurdy

series ordinal

3

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7 January 2020

publication date

14 September 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17874041%20AND%20SRC:MED&resulttype=core&format=json

Journal of Computer - Aided Molecular Design

7 January 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17874041%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

volume

21

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7 January 2020

issue

9

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7 January 2020

page(s)

511-522

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Characterization of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, an enzyme involved in isopentenyl diphosphate biosynthesis, and identification of its catalytic amino acid residues

7 January 2020

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Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: a molecular study

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Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step

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The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation

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Mycobacterial lipid II is composed of a complex mixture of modified muramyl and peptide moieties linked to decaprenyl phosphate

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Molecular modeling study of the editing active site of Escherichia coli leucyl-tRNA synthetase: two amino acid binding sites in the editing domain

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Susceptibility to levofloxacin of Myocobacterium tuberculosis isolates from patients with HIV-related tuberculosis and characterization of a strain with levofloxacin monoresistance. Community Programs for Clinical Research on AIDS 019 and the AIDS C

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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

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Genetic evidence of branching in the isoprenoid pathway for the production of isopentenyl diphosphate and dimethylallyl diphosphate in Escherichia coli

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Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with cofactors: implications of a flexible loop movement upon substrate binding

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An overview of structural genomics.

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Prediction of protein secondary structure at better than 70% accuracy

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Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development

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A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis

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Kinetic and chemical mechanism of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate isomeroreductase

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Biosynthesis of isoprenoids (carotenoids, sterols, prenyl side-chains of chlorophylls and plastoquinone) via a novel pyruvate/glyceraldehyde 3-phosphate non-mevalonate pathway in the green alga Scenedesmus obliquus

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Amino acid substitution matrices from protein blocks

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12 December 2020

The 1.9 A resolution structure of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a potential drug target

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12 December 2020

Recognition of the lipid intermediate for arabinogalactan/arabinomannan biosynthesis and its relation to the mode of action of ethambutol on mycobacteria

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Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate

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12 December 2020

Crystal structure of 1-deoxy-d-xylulose-5-phosphate reductoisomerase from Zymomonas mobilis at 1.9-A resolution

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Properties and inhibition of the first two enzymes of the non-mevalonate pathway of isoprenoid biosynthesis

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The nicotinamide dinucleotide binding motif: a comparison of nucleotide binding proteins

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The growing burden of tuberculosis: global trends and interactions with the HIV epidemic

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12 December 2020

Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-1-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis.

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12 December 2020

Crystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesis

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12 December 2020

Crystallographic structures of two bisphosphonate:1-deoxyxylulose-5-phosphate reductoisomerase complexes

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12 December 2020

Fosmidomycin, a novel chemotherapeutic agent for malaria

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12 December 2020

Comparative protein modeling of 1-deoxy-D-xylulose-5-phosphate reductoisomerase enzyme from Plasmodium falciparum: a potential target for antimalarial drug discovery.

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12 December 2020

Modeling of loops in protein structures

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Fosmidomycin for malaria

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Biosynthesis of the Linkage Region of the Mycobacterial Cell Wall

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Essential Bacillus subtilis genes

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12 December 2020

Annulling a dangerous liaison: vaccination strategies against AIDS and tuberculosis

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Multidrug-resistant Mycobacterium tuberculosis: molecular perspectives

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Signalling the fat controller

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12 December 2020

1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin

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12 December 2020

Analysis of the genome of Mycobacterium tuberculosis H37Rv

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12 December 2020

Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs

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12 December 2020

Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol

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12 December 2020

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

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12 December 2020

A new approach to analysis and display of local lipophilicity/hydrophilicity mapped on molecular surfaces

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12 December 2020

Molecular fingerprinting of clinical isolates of Mycobacterium bovis and Mycobacterium tuberculosis from India by restriction fragment length polymorphism (RFLP).

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1-Deoxy-D-xylulose 5-phosphate reductoisomerase: an overview

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Tuberculosis: commentary on a reemergent killer

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Comparative protein modelling by satisfaction of spatial restraints

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12 December 2020

10.1007/S10822-007-9132-0

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17874041%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

DBLP publication ID

journals/jcamd/SinghAM07

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DBLP Dataset 2021-01-02

28 January 2021

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