Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activator (Q81308496)

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7 January 2020

title

Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activator (English)

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7 January 2020

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Zhe Chen

1

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7 January 2020

William D Singer

series ordinal

2

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7 January 2020

Paul C Sternweis

series ordinal

3

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7 January 2020

Stephen R Sprang

series ordinal

4

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7 January 2020

publication date

16 January 2005

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Nature Structural & Molecular Biology

7 January 2020

published in

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7 January 2020

volume

12

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7 January 2020

issue

2

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7 January 2020

page(s)

191-197

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https://scigraph.springernature.com/pub.10.1038/nsmb888

7 January 2020

exact match

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cites work

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Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

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Modulation of the affinity and selectivity of RGS protein interaction with G alpha subunits by a conserved asparagine/serine residue

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Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A

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Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF

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Structure of the rgRGS domain of p115RhoGEF

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Structure of the RGS-like Domain from PDZ-RhoGEF

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Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor

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Mapping of effector binding sites of transducin alpha-subunit using G alpha t/G alpha i1 chimeras

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The Rho guanine nucleotide exchange factor Lsc homo-oligomerizes and is negatively regulated through domains in its carboxyl terminus that are absent in novel splenic isoforms

31 March 2020

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Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential

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31 March 2020

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Functional characterization of p115 RhoGEF.

31 March 2020

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Thermodynamic Characterization of the Binding of Activator of G Protein Signaling 3 (AGS3) and Peptides Derived from AGS3 with Gαi1

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NSMB888

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15665872%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

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