Proinsulin levels and the proinsulin:c-peptide ratio complement autoantibody measurement for predicting type 1 diabetes (Q81323909)

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7 January 2020

title

Proinsulin levels and the proinsulin:c-peptide ratio complement autoantibody measurement for predicting type 1 diabetes (English)

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7 January 2020

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I Truyen

1

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7 January 2020

P De Pauw

2

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7 January 2020

P N Jørgensen

3

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7 January 2020

C Van Schravendijk

4

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7 January 2020

O Ubani

5

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7 January 2020

K Decochez

6

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7 January 2020

E Vandemeulebroucke

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7 January 2020

I Weets

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7 January 2020

R Mao

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7 January 2020

D G Pipeleers

10

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7 January 2020

F K Gorus

11

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7 January 2020

Belgian Diabetes Registry

12

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7 January 2020

publication date

7 October 2005

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7 January 2020

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7 January 2020

volume

48

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7 January 2020

issue

11

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7 January 2020

page(s)

2322-2329

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Influence of age on the associations among insulin autoantibodies, islet cell antibodies, and HLA DAQ1*0301-DQB1*0302 in siblings of patients with type 1 (insulin-dependent) diabetes mellitus. Belgian Diabetes Registry

7 January 2020

cites work

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IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. The Belgian Diabetes Registry

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Highly sensitive enzyme immunoassay of proinsulin immunoreactivity with use of two monoclonal antibodies.

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Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release

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Elevated proinsulin levels related to islet cell antibodies in first-degree relatives of IDDM patients.

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Relationship between first-phase insulin secretion and age, HLA, islet cell antibody status, and development of type I diabetes in 220 juvenile first-degree relatives of diabetic patients

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Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies

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Can we really predict IDDM?

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Proinsulin and C-peptide at onset and during 12 months cyclosporin treatment of type 1 (insulin-dependent) diabetes mellitus

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Epidemiology, clinical aspects, and biology of IDDM patients under age 40 years. Comparison of data from Antwerp with complete ascertainment with data from Belgium with 40% ascertainment. The Belgian Diabetes Registry

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Interleukin-1beta-induced alteration in a beta-cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis

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Statistical analysis of the reproducibility of the intravenous glucose tolerance test and the serum insulin response to this test in the middle-aged men.

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Autoimmune type 1 diabetes: resolved and unresolved issues

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12 December 2020

Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation

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12 December 2020

Heterophile antibodies indicate progression of autoimmunity in human type 1 diabetes mellitus before clinical onset

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12 December 2020

Standardization of IVGTT to predict IDDM

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12 December 2020

Genetic susceptibility for insulin-dependent diabetes mellitus in Caucasians revisited: the importance of diabetes registries in disclosing interactions between HLA-DQ- and insulin gene-linked risk. Belgian Diabetes Registry

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12 December 2020

IA-2 autoantibodies predict impending type I diabetes in siblings of patients

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12 December 2020

First-degree relatives of patients with type I diabetes mellitus. Islet-cell antibodies and abnormal insulin secretion

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12 December 2020

Dynamic pattern of disease-associated autoantibodies in siblings of children with type 1 diabetes: a population-based study

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12 December 2020

Proinsulin-specific autoantibodies are relatively infrequent in young offspring with pre-type 1 diabetes

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12 December 2020

European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes

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12 December 2020

Proinsulin immunoreactivity in recent-onset IDDM: the significance of insulin antibodies and insulin autoantibodies

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12 December 2020

Transient antiislet autoantibodies: infrequent occurrence and lack of association with "genetic" risk factors

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12 December 2020

High frequency of persisting or increasing islet-specific autoantibody levels after diagnosis of type 1 diabetes presenting before 40 years of age. The Belgian Diabetes Registry

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12 December 2020

In praise of the hyperglycemic clamp. A method for assessment of beta-cell sensitivity and insulin resistance

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12 December 2020

Combined positivity for HLA DQ2/DQ8 and IA-2 antibodies defines population at high risk of developing type 1 diabetes

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12 December 2020

Increased proinsulin levels as an early indicator of B-cell dysfunction in non-diabetic twins of type 1 (insulin-dependent) diabetic patients.

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12 December 2020

Proinsulin levels in newborn siblings of type 1 (insulin-dependent) diabetic children and their mothers.

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12 December 2020

Elevated proinsulin in healthy siblings of IDDM patients independent of HLA identity

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12 December 2020

Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes. A population-based study. The Childhood Diabetes in Finland Study Group

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12 December 2020

Evidence of beta cell dysfunction which does not lead on to diabetes: a study of identical twins of insulin dependent diabetics

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12 December 2020

Insulin autoantibodies and high titre islet cell antibodies are preferentially associated with the HLA DQA1*0301-DQB1*0302 haplotype at clinical type 1 (insulin-dependent) diabetes mellitus before age 10 years, but not at onset between age 10 and 40

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12 December 2020

Disproportionately elevated proinsulin levels reflect the degree of impaired B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus.

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12 December 2020

Altered islet beta-cell function before the onset of type 1 (insulin-dependent) diabetes mellitus

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12 December 2020

Insulin resistance is a risk factor for progression to type 1 diabetes

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12 December 2020

Prospects for predicting and stopping the development of type 1 of diabetes

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12 December 2020

Interactions of age, islet cell antibodies, insulin autoantibodies, and first-phase insulin response in predicting risk of progression to IDDM in ICA+ relatives: the ICARUS data set. Islet Cell Antibody Register Users Study

1 reference

12 December 2020