Interactions of Npc1 and amyloid accumulation/deposition in the APP/PS1 mouse model of Alzheimer's (Q82954776)

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18 January 2020

title

Interactions of Npc1 and amyloid accumulation/deposition in the APP/PS1 mouse model of Alzheimer's (English)

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18 January 2020

author name string

Ivan A Borbon

series ordinal

1

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18 January 2020

Robert P Erickson

series ordinal

2

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18 January 2020

publication date

18 December 2010

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Journal of Applied Genetics

18 January 2020

published in

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18 January 2020

volume

52

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18 January 2020

issue

2

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18 January 2020

page(s)

213-218

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Apolipoprotein E isoform phenotyping methodology and population frequency with identification of apoE1 and apoE5 isoforms

18 January 2020

cites work

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12 December 2020

Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model.

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12 December 2020

Epistasis between intracellular cholesterol trafficking-related genes (NPC1 and ABCA1) and Alzheimer's disease risk.

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12 December 2020

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

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12 December 2020

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

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12 December 2020

Altered apolipoprotein E glycosylation is associated with Abeta(42) accumulation in an animal model of Niemann-Pick Type C disease.

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12 December 2020

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

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12 December 2020

Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice

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12 December 2020

Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells

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12 December 2020

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

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12 December 2020

Spatial and temporal distribution of intracellular free cholesterol in brains of a Niemann-Pick type C mouse model showing hyperphosphorylated tau protein. Implications for Alzheimer's disease

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12 December 2020

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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12 December 2020

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

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12 December 2020

A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease

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12 December 2020

Niemann-Pick C1 is a late endosome-resident protein that transiently associates with lysosomes and the trans-Golgi network

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12 December 2020

Niemann-Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the beta-secretase pathway

1 reference

12 December 2020

Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol

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12 December 2020

Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo.

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12 December 2020

Variation in NPC1, the gene encoding Niemann-Pick C1, a protein involved in intracellular cholesterol transport, is associated with Alzheimer disease and/or aging in the Polish population

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12 December 2020

Clues to neuro-degeneration in Niemann-Pick type C disease from global gene expression profiling

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12 December 2020

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

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12 December 2020

The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo

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12 December 2020

Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

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12 December 2020

Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts

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12 December 2020

Cholesterol in Alzheimer's disease and tauopathy

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12 December 2020

Identification of HE1 as the second gene of Niemann-Pick C disease

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12 December 2020

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12 December 2020

Impact of cholesterol level upon APP and BACE proximity and APP cleavage

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12 December 2020

Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

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12 December 2020

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

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12 December 2020

Cholesterol, statins and dementia.

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12 December 2020

Increased expression of caveolin-1 in heterozygous Niemann-Pick type II human fibroblasts

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12 December 2020

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

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12 December 2020

Neuronal membrane cholesterol loss enhances amyloid peptide generation

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12 December 2020

Mouse models of Alzheimer's disease: a quest for plaques and tangles

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12 December 2020

Lipid binding to amyloid beta-peptide aggregates: preferential binding of cholesterol as compared with phosphatidylcholine and fatty acids

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12 December 2020

Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease

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12 December 2020

Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse

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12 December 2020

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

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12 December 2020

Niemann-Pick type C disease: accelerated neurofibrillary tangle formation and amyloid beta deposition associated with apolipoprotein E epsilon 4 homozygosity

1 reference

12 December 2020

Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport

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12 December 2020

Decreased Npc1 gene dosage in mice is associated with weight gain

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12 December 2020

Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities

1 reference

12 December 2020

Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann-Pick type C murine model.

1 reference

12 December 2020

Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up.

1 reference

12 December 2020

Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene

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12 December 2020

10.1007/S13353-010-0021-1

Identifiers

DOI

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18 January 2020

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