T cells to a dominant epitope of GAD65 express a public CDR3 motif (Q83205902)

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20 January 2020

title

T cells to a dominant epitope of GAD65 express a public CDR3 motif (English)

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20 January 2020

author name string

Anthony Quinn

1

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20 January 2020

Marcia McInerney

2

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20 January 2020

Donald Huffman

3

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20 January 2020

Brigid McInerney

4

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20 January 2020

Stella Mayo

5

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20 January 2020

Kathryn Haskins

6

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20 January 2020

Eli Sercarz

7

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20 January 2020

publication date

26 April 2006

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20 January 2020

published in

International Immunology

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20 January 2020

volume

18

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20 January 2020

issue

6

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20 January 2020

page(s)

967-979

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Insulin-dependent diabetes mellitus: the initial lesion

20 January 2020

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Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

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Analysis of the spontaneous T cell response to insulin in NOD mice

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Treatment of Autoimmune Diabetes and Insulitis in NOD Mice With Heat Shock Protein 60 Peptide p277

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T-cell mediated autoimmunity to the insulinoma-associated protein 2 islet tyrosine phosphatase in type 1 diabetes mellitus

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Cellular immune response to phogrin in the NOD mouse: cloned T-cells cause destruction of islet transplants

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Mechanism underlying counterregulation of autoimmune diabetes by IL-4.

21 January 2018

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Regulatory and effector CD4 T cells in nonobese diabetic mice recognize overlapping determinants on glutamic acid decarboxylase and use distinct V beta genes

21 January 2018

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T cells with multiple fine specificities are used by non-obese diabetic (NOD) mice in the response to GAD(524-543).

21 January 2018

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Insulin-secreting non-islet cells are resistant to autoimmune destruction

21 January 2018

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T-cell repertoire diversity and clonal expansions in normal and clinical samples

21 January 2018

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Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor alpha chain gene rearrangement

21 January 2018

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Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell clone

21 January 2018

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Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors.

21 January 2018

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Sialadenitis in nonobese diabetic mice: transfer into syngeneic healthy neonates by splenic T lymphocytes

21 January 2018

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Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice.

21 January 2018

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Genetic control of autoimmune diabetes in the NOD mouse

21 January 2018

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A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes

21 January 2018

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DR, DQ, and you: MHC alleles and autoimmunity

21 January 2018

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Conformation-dependent GAD65 autoantibodies in diabetes

21 January 2018

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Development of glutamic acid decarboxylase 65 (GAD65) autoantibody assay using biotin-GAD65 fusion protein

21 January 2018

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GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes

21 January 2018

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Glutamic acid decarboxylase antibodies (GADA) is the most important factor for prediction of insulin therapy within 3 years in young adult diabetic patients not classified as Type 1 diabetes on clinical grounds

21 January 2018

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Expression of GAD65 and islet cell antibody (ICA512) autoantibodies among cytoplasmic ICA+ relatives is associated with eligibility for the Diabetes Prevention Trial-Type 1.

21 January 2018

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MHC-linked susceptibility to type 1 diabetes: a structural perspective

21 January 2018

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Binding of conserved islet peptides by human and murine MHC class II molecules associated with susceptibility to type I diabetes

21 January 2018

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Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice

21 January 2018

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Human DQ8 can substitute for murine I-Ag7 in the selection of diabetogenic T cells restricted to I-Ag7

21 January 2018

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Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 transgenic IA(null) NOD mice

21 January 2018

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Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis

21 January 2018

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Restricted heterogeneity in T-cell antigen receptor V beta gene usage in the lymph nodes and arthritic joints of mice

21 January 2018

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Regulatory T cells specific for the same framework 3 region of the Vbeta8.2 chain are involved in the control of collagen II-induced arthritis and experimental autoimmune encephalomyelitis

21 January 2018

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IFNgamma deficient C57BL/6 (H-2b) mice develop collagen induced arthritis with predominant usage of T cell receptor Vbeta6 and Vbeta8 in arthritic joints

21 January 2018

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T cell receptor restriction of diabetogenic autoimmune NOD T cells

21 January 2018

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T cell receptor gene polymorphisms associated with anti-insulin, autoimmune T cells in diabetes-prone NOD mice

21 January 2018

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The use of reverse transcription polymerase chain reaction to analyse large numbers of mRNA species from a single cell

21 January 2018

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Frequency of clonally expanded T cells evaluated by PCR from a single cell

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease

21 January 2018

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Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase

21 January 2018

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GAD-reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice.

21 January 2018

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Therapeutic alteration of insulin-dependent diabetes mellitus progression by T cell tolerance to glutamic acid decarboxylase 65 peptides in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXL033

MHC class I-restricted determinants on the glutamic acid decarboxylase 65 molecule induce spontaneous CTL activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXL033

An islet-homing NOD CD8+ cytotoxic T cell clone recognizes GAD65 and causes insulitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXL033

The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXL033

NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.

21 January 2018

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Diabetes results from a late change in the autoimmune response of NOD mice

21 January 2018

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Autoimmune diabetes: the involvement of benign and malignant autoimmunity

21 January 2018

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Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients

21 January 2018

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https://api.crossref.org/works/10.1093%2FINTIMM%2FDXL033

Report from the 1st International NOD Mouse T-Cell Workshop and the follow-up mini-workshop

21 January 2018

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How important is GAD in the etiology of spontaneous disease in human and murine type 1 diabetes?

21 January 2018

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HLA-DQ-regulated T-cell responses to islet cell autoantigens insulin and GAD65.

21 January 2018

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https://api.crossref.org/works/10.1093%2FINTIMM%2FDXL033

Dynamic changes of GAD65 autoantibody epitope specificities in individuals at risk of developing type 1 diabetes

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/INTIMM/DXL033

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16641112%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference