Synthesis and evaluation of potent ene-yne inhibitors of type II dehydroquinases as tuberculosis drug leads (Q83317100)

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21 January 2020

title

Synthesis and evaluation of potent ene-yne inhibitors of type II dehydroquinases as tuberculosis drug leads (English)

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21 January 2020

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7

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21 January 2020

Adrian Lapthorn

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21 January 2020

author name string

Anh Thu Tran

1

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21 January 2020

Katie M Cergol

2

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21 January 2020

Nicholas P West

3

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21 January 2020

Elizabeth J Randall

4

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21 January 2020

Warwick J Britton

5

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21 January 2020

Syed Ali Imran Bokhari

6

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Richard J Payne

9

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publication date

4 November 2010

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21 January 2020

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21 January 2020

volume

6

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21 January 2020

issue

2

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page(s)

262-265

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The shikimate pathway--a metabolic tree with many branches

21 January 2020

cites work

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Mycobacterial shikimate pathway enzymes as targets for drug design

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A comparison of the enzymological and biophysical properties of two distinct classes of dehydroquinase enzymes

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Identification of the active-site lysine residues of two biosynthetic 3-dehydroquinases

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THE ABSOLUTE STEREOCHEMICAL COURSE OF CITRIC ACID BIOSYNTHESIS

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The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor

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The Mycobacterium tuberculosis shikimate pathway genes: evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases

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7 January 2021

Cloning, sequencing, expression, purification and preliminary characterization of a type II dehydroquinase from Helicobacter pylori

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7 January 2021

Progress in type II dehydroquinase inhibitors: from concept to practice

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7 January 2021

Nanomolar Competitive Inhibitors ofMycobacterium tuberculosis andStreptomyces coelicolor Type II Dehydroquinase

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7 January 2021

Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues

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7 January 2021

Structure-based design, synthesis, and biological evaluation of inhibitors of Mycobacterium tuberculosis type II dehydroquinase

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7 January 2021

Competitive inhibitors of Helicobacter pylori type II dehydroquinase: synthesis, biological evaluation, and NMR studies.

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7 January 2021

Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases

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7 January 2021

Rational design, synthesis, and evaluation of nanomolar type II dehydroquinase inhibitors

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7 January 2021

Nanomolar inhibition of type II dehydroquinase based on the enolate reaction mechanism

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7 January 2021

Understanding the key factors that control the inhibition of type II dehydroquinase by (2R)-2-benzyl-3-dehydroquinic acids

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7 January 2021

The Sonogashira reaction: a booming methodology in synthetic organic chemistry.

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7 January 2021

A convenient synthesis of acetylenes: catalytic substitutions of acetylenic hydrogen with bromoalkenes, iodoarenes and bromopyridines

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7 January 2021

Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes

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7 January 2021

Novel and efficient syntheses of (-)-methyl 4-epi-shikimate and 4,5-epoxy-quinic and -shikimic acid derivatives as key precursors to prepare new analogues

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7 January 2021

Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium

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7 January 2021

Resazurin reduction assays for screening of anti-tubercular compounds against dormant and actively growing Mycobacterium tuberculosis, Mycobacterium bovis BCG and Mycobacterium smegmatis

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7 January 2021

Identifiers

DOI

10.1002/CMDC.201000399

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21 January 2020

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