Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-fed db/db mice (Q83412055)

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scientific article published on 14 February 2011

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English	Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-fed db/db mice	scientific article published on 14 February 2011

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22 January 2020

Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-fed db/db mice (English)

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22 January 2020

author name string

Kanji Yamaguchi

1

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22 January 2020

Yoshito Itoh

2

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22 January 2020

Chihiro Yokomizo

3

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22 January 2020

Takeshi Nishimura

4

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22 January 2020

Toshihisa Niimi

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22 January 2020

Atsushi Umemura

6

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22 January 2020

Hideki Fujii

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22 January 2020

Takeshi Okanoue

8

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22 January 2020

Toshikazu Yoshikawa

9

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22 January 2020

publication date

14 February 2011

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Laboratory Investigation

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22 January 2020

91

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22 January 2020

4

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22 January 2020

609-618

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22 January 2020

https://scigraph.springernature.com/pub.10.1038/labinvest.2011.2

0 references

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Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis

1 reference

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Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.

1 reference

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ICAM-1 triggers liver regeneration through leukocyte recruitment and Kupffer cell-dependent release of TNF-alpha/IL-6 in mice

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gp130 receptor ligands as potential therapeutic targets for obesity

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The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury

1 reference

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Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL.

1 reference

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Interleukin-6 inhibits oxidative injury and necrosis after extreme liver resection.

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Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

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Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet

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Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice

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Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization

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Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis.

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Anti-IL-6 receptor antibody increases blood IL-6 level via the blockade of IL-6 clearance, but not via the induction of IL-6 production

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