Intrathecal delivery of farnesyl thiosalicylic acid and GW 5074 attenuates hyperalgesia and allodynia in chronic constriction injury-induced neuropathic pain in rats (Q83553713)

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scientific article published on 02 March 2012

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English	Intrathecal delivery of farnesyl thiosalicylic acid and GW 5074 attenuates hyperalgesia and allodynia in chronic constriction injury-induced neuropathic pain in rats	scientific article published on 02 March 2012

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scholarly article

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24 January 2020

Intrathecal delivery of farnesyl thiosalicylic acid and GW 5074 attenuates hyperalgesia and allodynia in chronic constriction injury-induced neuropathic pain in rats (English)

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24 January 2020

author name string

Amteshwar Singh Jaggi

1

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24 January 2020

Nirmal Singh

2

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publication date

2 March 2012

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24 January 2020

Neurological Sciences

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34

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3

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24 January 2020

297-304

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24 January 2020

https://scigraph.springernature.com/pub.10.1007/s10072-012-0991-3

0 references

Characterization of Fasudil in preclinical models of pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

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Differential effect of spironolactone in chronic constriction injury and vincristine-induced neuropathic pain in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ameliorative effects of amiloride and pralidoxime in chronic constriction injury and vincristine induced painful neuropathy in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

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Experimental mononeuropathy reduces the antinociceptive effects of morphine: implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RhoA/Rho kinase pathway contributes to the pathogenesis of thermal hyperalgesia in diabetic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

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Neuroprotective effects of the Ras inhibitor S-trans-trans-farnesylthiosalicylic acid, measured by diffusion-weighted imaging after traumatic brain injury in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative assessment of tactile allodynia in the rat paw

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

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Inhibition of ATF-3 expression by B-Raf mediates the neuroprotective action of GW5074

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

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Changes in cardiovascular parameters and plasma norepinephrine level in rats after chronic constriction injury on the sciatic nerve

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

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Sustained morphine treatment augments capsaicin-evoked calcitonin gene-related peptide release from primary sensory neurons in a protein kinase A- and Raf-1-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

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The combined treatment of Copaxone and Salirasib attenuates experimental autoimmune encephalomyelitis (EAE) in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sustained morphine-mediated pain sensitization and antinociceptive tolerance are blocked by intrathecal treatment with Raf-1-selective siRNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spinal dynorphin immunoreactivity increases bilaterally in a neuropathic pain model

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Animal models of neuropathic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic targets for the management of peripheral nerve injury-induced neuropathic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Farnesyl derivatives of rigid carboxylic acids-inhibitors of ras-dependent cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Ras attenuates the course of experimental autoimmune neuritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of MEK1 as a novel target for the treatment of neuropathic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of Rho-kinase in inflammatory and neuropathic pain through phosphorylation of myristoylated alanine-rich C-kinase substrate (MARCKS).

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel Ras antagonist regulates both oncogenic Ras and the tumor suppressor p53 in colon cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axonal accumulation of hyperpolarization-activated cyclic nucleotide-gated cation channels contributes to mechanical allodynia after peripheral nerve injury in rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysregulation of cellular calcium homeostasis in chemotherapy-evoked painful peripheral neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dislodgment and accelerated degradation of Ras.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Salirasib (farnesyl thiosalicylic acid) for brain tumor treatment: a convection-enhanced drug delivery study in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sustained morphine treatment augments basal CGRP release from cultured primary sensory neurons in a Raf-1 dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho-kinase inhibition enhances axonal plasticity and attenuates cold hyperalgesia after dorsal rhizotomy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphometric study of the sensory neuron and peripheral nerve changes induced by chronic cisplatin (DDP) administration in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Effects of fasudil on neuropathic pain-like state in mice]

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathic pain: aetiology, symptoms, mechanisms, and management

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new approach to Parkinson's disease: inhibition of leucine-rich repeat kinase-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian target of rapamycin in spinal cord neurons mediates hypersensitivity induced by peripheral inflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological characterisation of the spared nerve injury model of neuropathic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrathecal Raf-1-selective siRNA attenuates sustained morphine-mediated thermal hyperalgesia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Raf inhibition protects cortical cells against beta-amyloid toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of chronically active ras: potential for treatment of human malignancies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An animal model of neuropathic pain employing injury to the sciatic nerve branches

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Ras-pathway inhibitor, S-trans-trans-farnesylthiosalicylic acid, suppresses experimental allergic encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10072-012-0991-3

1 reference

Europe PubMed Central

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24 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22382741%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

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