The role of NF-kappaB and Smad3 in TGF-beta-mediated Foxp3 expression (Q84454567)

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6 February 2020

title

The role of NF-kappaB and Smad3 in TGF-beta-mediated Foxp3 expression (English)

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6 February 2020

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Srikanta Jana

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Parthav Jailwala

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Dipica Haribhai

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Jill Waukau

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Sanja Glisic

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William Grossman

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Manoj Mishra

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Renren Wen

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Demin Wang

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Calvin B Williams

10

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Soumitra Ghosh

11

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publication date

1 September 2009

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European Journal of Immunology

6 February 2020

published in

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6 February 2020

volume

39

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6 February 2020

issue

9

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6 February 2020

page(s)

2571-2583

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Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease

6 February 2020

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The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

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Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.

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Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes

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Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells

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Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo

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7 January 2021

Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells

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7 January 2021

A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-beta

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7 January 2021

IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells

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7 January 2021

TGF-beta signal transduction

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7 January 2021

Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease

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7 January 2021

Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable

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7 January 2021

TGF regulates the CD4+CD25+ T-cell pool and the expression of Foxp3 in vivo

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7 January 2021

TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

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7 January 2021

Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers

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7 January 2021

CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2

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7 January 2021

A function for interleukin 2 in Foxp3-expressing regulatory T cells

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7 January 2021

Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

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7 January 2021

Nonredundant roles for Stat5a/b in directly regulating Foxp3

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7 January 2021

IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

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7 January 2021

Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation

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7 January 2021

Mature T cells depend on signaling through the IKK complex.

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7 January 2021

Molecular mechanisms underlying FOXP3 induction in human T cells

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CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation.

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7 January 2021

Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses

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7 January 2021

Multiple immuno-regulatory defects in type-1 diabetes

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7 January 2021

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7 January 2021

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

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7 January 2021

The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

The therapeutic potential of tumor necrosis factor for autoimmune disease: a mechanistically based hypothesis

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7 January 2021

Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells

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7 January 2021

A mutant Stat5b with weaker DNA binding affinity defines a key defective pathway in nonobese diabetic mice

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7 January 2021

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7 January 2021

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7 January 2021

At-risk and recent-onset type 1 diabetic subjects have increased apoptosis in the CD4+CD25+ T-cell fraction

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7 January 2021

Identifiers

DOI

10.1002/EJI.200939201

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19701891%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

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