Pharmacokinetic and pharmacodynamic modelling of the novel human granulocyte colony-stimulating factor derivative Maxy-G34 and pegfilgrastim in rats (Q84587218)

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scientific article published on 24 September 2009

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English	Pharmacokinetic and pharmacodynamic modelling of the novel human granulocyte colony-stimulating factor derivative Maxy-G34 and pegfilgrastim in rats	scientific article published on 24 September 2009

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19780759%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Pharmacokinetic and pharmacodynamic modelling of the novel human granulocyte colony-stimulating factor derivative Maxy-G34 and pegfilgrastim in rats (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19780759%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

pharmacodynamics

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

inferred from title

Christoph Engel

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496908&resulttype=core&format=json

14 May 2020

author name string

M Scholz

1

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Europe PubMed Central

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14 May 2020

D Apt

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496908&resulttype=core&format=json

14 May 2020

S L Sankar

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496908&resulttype=core&format=json

14 May 2020

E Goldstein

5

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496908&resulttype=core&format=json

14 May 2020

M Loeffler

6

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496908&resulttype=core&format=json

14 May 2020

publication date

24 September 2009

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19780759%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Cell Proliferation

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496908&resulttype=core&format=json

14 May 2020

42

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496908&resulttype=core&format=json

14 May 2020

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496908&resulttype=core&format=json

14 May 2020

823-837

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496908&resulttype=core&format=json

14 May 2020

Modelling human granulopoiesis under poly-chemotherapy with G-CSF support.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum levels of endogenous and exogenous granulocyte colony-stimulating factor after autologous blood stem cell transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical uses of pegylated pharmaceuticals in oncology

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of neutrophil homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a novel in vivo control mechanism of granulopoiesis: mature cell-related control of a regulatory growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of recombinant human granulocyte colony-stimulating factor conjugated to polyethylene glycol in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutrophil elastase enzymatically antagonizes the in vitro action of G-CSF: implications for the regulation of granulopoiesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that the granulocyte colony-stimulating factor (G-CSF) receptor plays a role in the pharmacokinetics of G-CSF and PegG-CSF using a G-CSF-R KO model

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increasing chemotherapy dose density and intensity: phase I trials in non-small cell lung cancer and non-Hodgkin's lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Practicability and acute haematological toxicity of 2- and 3-weekly CHOP and CHOEP chemotherapy for aggressive non-Hodgkin's lymphoma: results from the NHL-B trial of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of pegfilgrastim with filgrastim on febrile neutropenia, grade IV neutropenia and bone pain: a meta-analysis of randomized controlled trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative Relationships Between Circulating Leukocytes and Infection in Patients with Acute Leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proliferation of normal human promyelocytes and myelocytes after a single pulse stimulation by purified GM-CSF or G-CSF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of polymorphonuclear neutrophils (PMNs) in clearance of granulocyte colony-stimulating factor (G-CSF) in vivo and in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and pharmacodynamics of a recombinant human granulocyte colony-stimulating factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of human G-CSF receptor mRNA and protein in normal and leukemic myeloid cells by G-CSF and retinoic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo analysis of the effects of recombinant human granulocyte colony-stimulating factor in patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and pharmacodynamics of recombinant human granulocyte-colony stimulating factor after intravenous and subcutaneous administration in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Saturable uptake of a recombinant human granulocyte colony-stimulating factor derivative, nartograstim, by the bone marrow and spleen of rats in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic factors for hematotoxicity of chemotherapy in aggressive non-Hodgkin's lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Granulocyte colony-stimulating factor receptor mRNA upregulation is an immediate early marker of myeloid differentiation and exhibits dysfunctional regulation in leukemic cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Colony-stimulating factors for the management of neutropenia in cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A computational model of human granulopoiesis to simulate the hematotoxic effects of multicycle polychemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effectiveness of cytopenia prophylaxis for different filgrastim and pegfilgrastim schedules in a chemotherapy mouse model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Population pharmacokinetic-pharmacodynamic modeling of filgrastim (r-metHuG-CSF) in healthy volunteers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor-mediated clearance of G-CSF derivative nartograstim in bone marrow of rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current management of chemotherapy-induced neutropenia: the role of colony-stimulating factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutrophil activation and hemostatic changes in healthy donors receiving granulocyte colony-stimulating factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyethylene glycol modification of filgrastim results in decreased renal clearance of the protein in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutropenic event risk and impaired chemotherapy delivery in six European audits of breast cancer treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-level pharmacokinetic model of granulocyte colony-stimulating factor: implications for ligand lifetime and potency in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequency of febrile neutropenia in breast cancer patients receiving epirubicin and docetaxel/paclitaxel with colony-stimulating growth factors: a comparison of filgrastim or lenograstim with pegfilgrastim.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic/pharmacodynamic modeling of pegfilgrastim in healthy subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and dynamic modulation of the human granulocyte colony-stimulating factor receptor in immature and differentiated myeloid cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of escalating doses of recombinant human granulocyte colony-stimulating factor (filgrastim) on circulating neutrophils in healthy subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G-CSF down-regulation of CXCR4 expression identified as a mechanism for mobilization of myeloid cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimising management of neutropenia and anaemia in cancer chemotherapy-advances in cytokine therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparable efficacy and safety profiles of once-per-cycle pegfilgrastim and daily injection filgrastim in chemotherapy-induced neutropenia: a multicenter dose-finding study in women with breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Open-label, Randomized Study of Pegfilgrastim vs. Daily Filgrastim as an Adjunct to Chemotherapy in Elderly Patients with Non-Hodgkin's Lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Model-based design of chemotherapeutic regimens that account for heterogeneity in leucopoenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonlinear pharmacokinetics of a recombinant human granulocyte colony-stimulating factor derivative (nartograstim): species differences among rats, monkeys and humans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The kinetics of human granulopoiesis following treatment with granulocyte colony-stimulating factor in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of renal and hepatic failure on the pharmacokinetics of recombinant human granulocyte colony-stimulating factor (KRN8601) in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphonuclear leukocytes released from the bone marrow by granulocyte colony-stimulating factor: intravascular behavior

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimation of rhG-CSF absorption kinetics after subcutaneous administration using a modified Wagner-Nelson method with a nonlinear elimination model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic cleavage of granulocyte colony‐stimulating factor and its receptor by neutrophil elastase induces growth inhibition and decreased cell surface expression of the granulocyte colony‐stimulating factor receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The rate of apoptosis in post mitotic neutrophil precursors of normal and neutropenic humans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19780759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2184.2009.00641.X

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496908&resulttype=core&format=json

14 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496908&resulttype=core&format=json

14 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496908&resulttype=core&format=json

14 May 2020

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