The cytotoxic activity of Aplidin in chronic lymphocytic leukemia (CLL) is mediated by a direct effect on leukemic cells and an indirect effect on monocyte-derived cells (Q84878923)

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scientific article published on 02 September 2011

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English	The cytotoxic activity of Aplidin in chronic lymphocytic leukemia (CLL) is mediated by a direct effect on leukemic cells and an indirect effect on monocyte-derived cells	scientific article published on 02 September 2011

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21887502%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

The cytotoxic activity of Aplidin in chronic lymphocytic leukemia (CLL) is mediated by a direct effect on leukemic cells and an indirect effect on monocyte-derived cells (English)

1 reference

Europe PubMed Central

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12 February 2020

1 reference

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inferred from title

chronic lymphocytic leukemia

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based on heuristic

inferred from title

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21887502%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

author name string

Pablo E Morande

1

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12 February 2020

Samanta R Zanetti

2

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12 February 2020

Paula Nannini

4

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12 February 2020

Carolina Jancic

5

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12 February 2020

Raimundo F Bezares

6

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12 February 2020

Alicia Bitsmans

7

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12 February 2020

Miguel González

8

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12 February 2020

Andrea L Rodríguez

9

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12 February 2020

Carlos M Galmarini

10

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12 February 2020

Romina Gamberale

11

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12 February 2020

Mirta Giordano

12

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12 February 2020

publication date

2 September 2011

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12 February 2020

Investigational New Drugs

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12 February 2020

30

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12 February 2020

5

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Europe PubMed Central

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12 February 2020

1830-1840

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21887502%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

T-cell function in chronic lymphocytic leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plitidepsin Cellular Binding and Rac1/JNK Pathway Activation Depend on Membrane Cholesterol Content

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IGHV unmutated CLL B cells are more prone to spontaneous apoptosis and subject to environmental prosurvival signals than mutated CLL B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-malignant leukocytes delay spontaneous B-CLL cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory properties of the novel antitumor agent yondelis (trabectedin): inhibition of macrophage differentiation and cytokine production

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic lymphocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the human equilibrative nucleoside transporter1 (hENT1) activity by IL-4 and PMA in B cells from chronic lymphocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monitoring the apoptotic process induced by oxidized low-density lipoprotein in Jurkat T-lymphoblast and U937 monocytic human cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mechanism of action of plitidepsin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myeloid-derived suppressor cells as regulators of the immune system

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reports of clinical benefit of plitidepsin (Aplidine), a new marine-derived anticancer agent, in patients with advanced medullary thyroid carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Marine organisms as a source of new anticancer agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of ROS and RNS in regulating life and death of blood monocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myeloid-derived suppressor cells: linking inflammation and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CXCL12-induced chemotaxis is impaired in T cells from patients with ZAP-70-negative chronic lymphocytic leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural products as sources of new drugs over the last 25 years

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic lymphocytic leukemia: ESMO minimum clinical recommendations for diagnosis, treatment and follow-up

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A review of trabectedin (ET-743): a unique mechanism of action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II clinical and pharmacokinetic study of plitidepsin 3-hour infusion every two weeks alone or with dexamethasone in relapsed and refractory multiple myeloma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidation and inactivation of low molecular weight protein tyrosine phosphatase by the anticancer drug Aplidin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapy of chronic lymphocytic leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The clinical application of monoclonal antibodies in chronic lymphocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid and selective apoptosis in human leukemic cells induced by Aplidine through a Fas/CD95- and mitochondrial-mediated mechanism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic lymphocytic leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II study of biweekly plitidepsin as second-line therapy in patients with advanced malignant melanoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microenvironmental influences in chronic lymphocytic leukaemia: the role of antigen stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21887502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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