TP53 mutation profile in chronic lymphocytic leukemia: evidence for a disease specific profile from a comprehensive analysis of 268 mutations (Q85068912)

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scientific article published on 23 September 2010

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English	TP53 mutation profile in chronic lymphocytic leukemia: evidence for a disease specific profile from a comprehensive analysis of 268 mutations	scientific article published on 23 September 2010

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scholarly article

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TP53 mutation profile in chronic lymphocytic leukemia: evidence for a disease specific profile from a comprehensive analysis of 268 mutations (English)

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chronic lymphocytic leukemia

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author name string

T Zenz

1

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D Vollmer

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M Trbusek

3

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J Smardova

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A Benner

5

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H Helfrich

7

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M Heuberger

8

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P Hoth

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M Fuge

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T Denzel

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S Häbe

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J Malcikova

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P Kuglik

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S Truong

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N Patten

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L Wu

17

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D Oscier

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R Ibbotson

19

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A Gardiner

20

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I Tracy

21

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K Lin

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A Pettitt

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S Pospisilova

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J Mayer

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M Hallek

26

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H Döhner

27

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S Stilgenbauer

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European Research Initiative on CLL (ERIC)

29

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publication date

23 September 2010

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2072-2079

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https://scigraph.springernature.com/pub.10.1038/leu.2010.208

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Structural biology of the tumor suppressor p53.

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p53 alterations in human cancer: more questions than answers.

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Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up

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The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype

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The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness.

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Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial.

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Monoallelic and biallelic inactivation of TP53 gene in chronic lymphocytic leukemia: selection, impact on survival, and response to DNA damage

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Inactivation of p53 and deletion of ATM in B-CLL patients in relation to IgVH mutation status and previous treatment

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A unique spectrum of p53 mutations in B-cell chronic lymphocytic leukemia distinct from that of other lymphoid malignancies

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Pooled analysis of p53 mutations in hematological malignancies.

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A simple p53 functional assay for screening cell lines, blood, and tumors

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Rare somatic p53 mutation identified in breast cancer: a case report

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Determination of optimal conditions for analysis of p53 status in leukemic cells using functional analysis of separated alleles in yeast.

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Field cancerisation and polyclonal p53 mutation in the upper aero- digestive tract

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Identification of somatic hypermutations in the TP53 gene in B-cell chronic lymphocytic leukemia

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Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic lymphocytic leukemia

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MUT-TP53: a versatile matrix for TP53 mutation verification and publication

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Meta-analysis of the p53 Mutation Database for Mutant p53 Biological Activity Reveals a Methodologic Bias in Mutation Detection

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Reassessment of the TP53 mutation database in human disease by data mining with a library of TP53 missense mutations

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Identifiers

10.1038/LEU.2010.208

1 reference

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Dimensions Publication ID

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