Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect (Q85248436)

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16 February 2020

title

Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect (English)

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16 February 2020

9

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16 February 2020

Hervé Falet

14

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16 February 2020

author name string

Markus Bender

1

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16 February 2020

Simon Stritt

2

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16 February 2020

Paquita Nurden

3

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16 February 2020

Judith M M van Eeuwijk

4

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16 February 2020

Barbara Zieger

5

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16 February 2020

Karim Kentouche

6

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16 February 2020

Harald Schulze

7

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16 February 2020

Henner Morbach

8

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16 February 2020

Katrin G Heinze

10

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16 February 2020

Sebastian Dütting

11

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16 February 2020

Shuchi Gupta

12

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16 February 2020

Walter Witke

13

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16 February 2020

Alain Fischer

15

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16 February 2020

John H Hartwig

16

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16 February 2020

Bernhard Nieswandt

17

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16 February 2020

publication date

4 September 2014

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16 February 2020

published in

Nature Communications

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16 February 2020

volume

5

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16 February 2020

page(s)

4746

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The biogenesis of platelets from megakaryocyte proplatelets

16 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5746

7 January 2021

WASP: a key immunological multitasker

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7 January 2021

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

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7 January 2021

WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP).

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7 January 2021

Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP.

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7 January 2021

Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation

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7 January 2021

Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment

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7 January 2021

A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP

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7 January 2021

WIP null mice display a progressive immunological disorder that resembles Wiskott-Aldrich syndrome.

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7 January 2021

Cellular motility driven by assembly and disassembly of actin filaments

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7 January 2021

The role of profilin complexes in cell motility and other cellular processes

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7 January 2021

Profilin I is essential for cell survival and cell division in early mouse development

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7 January 2021

Regulation of Phospholipase C-γ1 by Profilin and Tyrosine Phosphorylation

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7 January 2021

The essential role of profilin in the assembly of actin for microspike formation

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7 January 2021

WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells

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7 January 2021

Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane

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7 January 2021

Cytoskeleton: functions for tubulin modifications at last

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7 January 2021

ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing

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7 January 2021

Motor-driven marginal band coiling promotes cell shape change during platelet activation.

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7 January 2021

mDia mediates Rho-regulated formation and orientation of stable microtubules

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7 January 2021

In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly

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7 January 2021

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation

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7 January 2021

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

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7 January 2021

Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo

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7 January 2021

WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation

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7 January 2021

Collagen-platelet interaction: Gly-Pro-Hyp is uniquely specific for platelet Gp VI and mediates platelet activation by collagen

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7 January 2021

A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis

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7 January 2021

Wiskott-Aldrich syndrome: qualitative platelet defects and short platelet survival

1 reference

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7 January 2021

X-linked thrombocytopenia and Wiskott-Aldrich syndrome are allelic diseases with mutations in the WASP gene

1 reference

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7 January 2021

Rapid platelet turnover in WASP(-) mice correlates with increased ex vivo phagocytosis of opsonized WASP(-) platelets

1 reference

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7 January 2021

Identifiers

DOI

10.1038/NCOMMS5746

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25187265%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

16 February 2020

ADS bibcode

2014NatCo...5.4746B

0 references

1006640801

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1 reference