5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (Q858317)

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mammalian protein found in Homo sapiens

• AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme
• epididymis secretory sperm binding protein Li 70p
• phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
• bifunctional purine biosynthesis protein PURH
• ATIC
• 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase
• AICARFT/IMPCHASE

edit

Language	Label	Description	Also known as
English	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	mammalian protein found in Homo sapiens	AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme epididymis secretory sperm binding protein Li 70p phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase bifunctional purine biosynthesis protein PURH ATIC 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase AICARFT/IMPCHASE

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P31939

part of

Cytidine deaminase-like

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P31939

AICAR transformylase, duplicated domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P31939

Bifunctional purine biosynthesis protein PurH-like

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P31939

Methylglyoxal synthase-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P31939

AICAR transformylase, insert domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P31939

Methylglyoxal synthase-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P31939

encoded by

ATIC

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P31939

molecular function

transferase activity

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31939

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

protein homodimerization activity

determination method

IPI

2 references

retrieved

9 May 2019

stated in

Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor

GOA

curator

UniProt

UniProt protein ID

P31939

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IPI

retrieved

9 May 2019

stated in

Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates

GOA

curator

UniProt

UniProt protein ID

P31939

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IPI

IMP cyclohydrolase activity

determination method

IEA

TAS

4 references

retrieved

8 April 2019

stated in

The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31939

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

catalytic activity

determination method

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31939

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

phosphoribosylaminoimidazolecarboxamide formyltransferase activity

determination method

IEA

TAS

4 references

retrieved

8 April 2019

stated in

The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31939

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

hydrolase activity

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31939

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

cadherin binding

determination method

IDA

1 reference

retrieved

26 September 2017

stated in

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31939&geneProductId=UniProtKB:P31939

determination method

IDA

cadherin binding

determination method

HDA

1 reference

retrieved

9 May 2019

stated in

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

HDA

IMP cyclohydrolase activity

determination method

IBA

IEA

TAS

5 references

retrieved

9 May 2019

stated in

The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

TAS

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31939

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IBA

phosphoribosylaminoimidazolecarboxamide formyltransferase activity

determination method

IBA

IEA

TAS

5 references

retrieved

9 May 2019

stated in

The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

TAS

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31939

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IBA

cell component

cytosol

determination method

TAS

1 reference

retrieved

26 September 2017

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31939&geneProductId=UniProtKB:P31939

determination method

TAS

membrane

determination method

IDA

1 reference

retrieved

26 September 2017

stated in

Defining the membrane proteome of NK cells

GOA

curator

UniProt

UniProt protein ID

P31939

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31939&geneProductId=UniProtKB:P31939

determination method

IDA

mitochondrion

determination method

IEA

1 reference

retrieved

26 September 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31939&geneProductId=UniProtKB:P31939

determination method

IEA

extracellular exosome

determination method

IDA

3 references

retrieved

26 September 2017

stated in

Large-scale proteomics and phosphoproteomics of urinary exosomes

GOA

curator

UniProt

UniProt protein ID

P31939

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31939&geneProductId=UniProtKB:P31939

determination method

IDA

retrieved

26 September 2017

stated in

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

GOA

curator

UniProt

UniProt protein ID

P31939

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31939&geneProductId=UniProtKB:P31939

determination method

IDA

retrieved

26 September 2017

stated in

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

GOA

curator

UniProt

UniProt protein ID

P31939

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31939&geneProductId=UniProtKB:P31939

determination method

IDA

cytosol

determination method

IDA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IDA

plasma membrane

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IDA

membrane

determination method

HDA

1 reference

retrieved

9 May 2019

stated in

Defining the membrane proteome of NK cells

GOA

curator

UniProt

UniProt protein ID

P31939

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

HDA

extracellular exosome

determination method

HDA

3 references

retrieved

9 May 2019

stated in

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

GOA

curator

UniProt

UniProt protein ID

P31939

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

HDA

retrieved

9 May 2019

stated in

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

GOA

curator

UniProt

UniProt protein ID

P31939

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

HDA

retrieved

9 May 2019

stated in

Large-scale proteomics and phosphoproteomics of urinary exosomes

GOA

curator

UniProt

UniProt protein ID

P31939

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

HDA

cytosol

determination method

IBA

IDA

TAS

3 references

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

TAS

retrieved

9 May 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IBA

biological process

purine nucleotide biosynthetic process

determination method

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31939

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

dihydrofolate metabolic process

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

'de novo' IMP biosynthetic process

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31939

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

brainstem development

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

ribonucleotide metabolic process

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

cerebellum development

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

nucleoside metabolic process

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

tetrahydrofolate biosynthetic process

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

animal organ regeneration

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

response to inorganic substance

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

cerebral cortex development

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

purine ribonucleoside monophosphate biosynthetic process

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

TAS

metabolism

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31939

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

nucleobase-containing compound metabolic process

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

TAS

cellular response to interleukin-7

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

'de novo' IMP biosynthetic process

determination method

IBA

IEA

3 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31939

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31939

determination method

IBA

Gene Atlas image

PBB GE ATIC 208758 at fs.png
732 × 530; 11 KB

0 references

has part(s)

Methylglyoxal synthase-like domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P31939

Identifiers

RefSeq protein ID

NP_004035

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

471

XP_016859676

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

471

XP_024308687

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

471

UniProt protein ID

P31939

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P31939

Ensembl protein ID

ENSP00000236959

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000236959

ENSP00000415935

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000415935

ENSP00000388675

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000388675

ENSP00000394317

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000394317

ENSP00000401936

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000401936

ENSP00000402393

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000402393

ENSP00000406792

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000406792

Freebase ID

/m/02rctw5

0 references

PDB structure ID

1P4R

1 reference

stated in

UniProt

UniProt protein ID

P31939

retrieved

9 August 2016

language of work or name

English

1PKX

1 reference

stated in

UniProt

UniProt protein ID

P31939

retrieved

9 August 2016

language of work or name

English

1PL0

1 reference

stated in

UniProt

UniProt protein ID

P31939

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(9 entries)

edit

• cywiki ATIC
• dewiki Bifunktionelles Purinsyntheseprotein
• enwiki Inosine monophosphate synthase
• kowiki 이노신 일인산 생성효소
• ptwiki Inosina monofosfato sintase
• shwiki Inozin monofosfatna sintaza
• srwiki Inozin monofosfatna sintaza
• ukwiki ATIC
• viwiki Inosine monophosphate synthase

Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q858317&oldid=2039562373"