Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial (Q87702640)

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scientific article published on 14 April 2014

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English	Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial	scientific article published on 14 April 2014

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scholarly article

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14 March 2020

Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial (English)

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phase III clinical trial

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1

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Claudine Isaacs

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Claudine Isaacs

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Ruth O'Regan

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Norikazu Masuda

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object named as

Norikazu Masuda

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Masakazu Toi

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author name string

Mustafa Ozguroglu

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Binghe Xu

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Guy Jerusalem

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Sharon Wilks

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Zsuzsanna Papai

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Istvan Lang

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Anne Armstrong

14

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Guillermo Lerzo

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Michelle White

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Kunwei Shen

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Jennifer Litton

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David Chen

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Yufen Zhang

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Shyanne Ali

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Tetiana Taran

22

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publication date

14 April 2014

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14 March 2020

Lancet Oncology Commission

1 reference

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15

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6

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580-591

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14 March 2020

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

1 reference

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7 January 2021

based on heuristic

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

1 reference

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7 January 2021

based on heuristic

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Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Outcome of patients with HER2-positive advanced breast cancer progressing during trastuzumab-based therapy

1 reference

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7 January 2021

based on heuristic

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Capecitabine and trastuzumab in heavily pretreated metastatic breast cancer.

1 reference

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7 January 2021

based on heuristic

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Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer

1 reference

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based on heuristic

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Lapatinib plus capecitabine for HER2-positive advanced breast cancer

1 reference

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7 January 2021

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Trastuzumab emtansine for HER2-positive advanced breast cancer

1 reference

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7 January 2021

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Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy

1 reference

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7 January 2021

based on heuristic

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A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2814%2970138-X

7 January 2021

based on heuristic

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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2814%2970138-X

7 January 2021

based on heuristic

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Breast cancer--loss of PTEN predicts resistance to treatment

1 reference

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7 January 2021

based on heuristic

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PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib

1 reference

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7 January 2021

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Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

1 reference

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Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency.

1 reference

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Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells

1 reference

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Antitumor effect of the mTOR inhibitor everolimus in combination with trastuzumab on human breast cancer stem cells in vitro and in vivo

1 reference

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based on heuristic

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Phase I trial of oral mTOR inhibitor everolimus in combination with trastuzumab and vinorelbine in pre-treated patients with HER2-overexpressing metastatic breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2814%2970138-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Phase I study of everolimus plus weekly paclitaxel and trastuzumab in patients with metastatic breast cancer pretreated with trastuzumab

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2814%2970138-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2814%2970138-X

7 January 2021

based on heuristic

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Phase III randomized study comparing docetaxel plus trastuzumab with vinorelbine plus trastuzumab as first-line therapy of metastatic or locally advanced human epidermal growth factor receptor 2-positive breast cancer: the HERNATA study

1 reference

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7 January 2021

based on heuristic

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Trastuzumab plus vinorelbine or taxane chemotherapy for HER2-overexpressing metastatic breast cancer: the trastuzumab and vinorelbine or taxane study

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2814%2970138-X

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based on heuristic

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Sorafenib in combination with capecitabine: an oral regimen for patients with HER2-negative locally advanced or metastatic breast cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2814%2970138-X

7 January 2021

based on heuristic

inferred from DOI database lookup

SABRE-B: an evaluation of paclitaxel and bevacizumab with or without sunitinib as first-line treatment of metastatic breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2814%2970138-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2814%2970138-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Phase 3 trial of everolimus for metastatic renal cell carcinoma : final results and analysis of prognostic factors

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2814%2970138-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Everolimus plus exemestane in postmenopausal patients with HR(+) breast cancer: BOLERO-2 final progression-free survival analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2814%2970138-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Semiquantitative hormone receptor level influences response to trastuzumab-containing neoadjuvant chemotherapy in HER2-positive breast cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2814%2970138-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Therapeutic implications of estrogen receptor signaling in HER2-positive breast cancers

1 reference

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7 January 2021

based on heuristic

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Which patients benefit most from adjuvant aromatase inhibitors? Results using a composite measure of prognostic risk in the BIG 1-98 randomized trial.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Frequent mutational activation of the PI3K-AKT pathway in trastuzumab-resistant breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2814%2970138-X

7 January 2021

based on heuristic

inferred from DOI database lookup

PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2814%2970138-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Impact of PTEN protein expression on benefit from adjuvant trastuzumab in early-stage human epidermal growth factor receptor 2-positive breast cancer in the North Central Cancer Treatment Group N9831 trial

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Evaluation of the association of PIK3CA mutations and PTEN loss with efficacy of trastuzumab therapy in metastatic breast cancer.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: a GINECO study

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S1470-2045(14)70138-X

1 reference

Europe PubMed Central

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14 March 2020

1 reference

Europe PubMed Central

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14 March 2020

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