Two Decades-Long Journey from Riluzole to Edaravone: Revisiting the Clinical Pharmacokinetics of the Only Two Amyotrophic Lateral Sclerosis Therapeutics (Q88437167)

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scientific article published on 01 November 2018

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English	Two Decades-Long Journey from Riluzole to Edaravone: Revisiting the Clinical Pharmacokinetics of the Only Two Amyotrophic Lateral Sclerosis Therapeutics	scientific article published on 01 November 2018

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29682695%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Two Decades-Long Journey from Riluzole to Edaravone: Revisiting the Clinical Pharmacokinetics of the Only Two Amyotrophic Lateral Sclerosis Therapeutics (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29682695%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

amyotrophic lateral sclerosis

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

inferred from title

Nuggehally R Srinivas

3

object named as

Nuggehally R Srinivas

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29682695%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

author name string

Ranjeet Prasad Dash

1

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24 March 2020

R Jayachandra Babu

2

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24 March 2020

publication date

1 November 2018

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24 March 2020

Clinical Pharmacokinetics

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29682695%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

57

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24 March 2020

11

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24 March 2020

1385-1398

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29682695%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Criteria for diagnosis of familial amyotrophic lateral sclerosis. European FALS Collaborative Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered glutamatergic mechanisms and selective motor neuron degeneration in amyotrophic lateral sclerosis: possible role of glycine

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caffeine as a metabolic probe: exploration of the enzyme-inducing effect of cigarette smoking

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Motor neuron disease (amyotrophic lateral sclerosis).

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical features and associations of 560 cases of motor neuron disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate dehydrogenase and aspartate aminotransferase in leukocytes of patients with motor neuron disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pilot trial of branched-chain aminoacids in amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyotrophic lateral sclerosis: Part 1. Clinical features, pathology, and ethical issues in management

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathology of amyotrophic lateral sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomized, double-blind, controlled trial of acetylcysteine in amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Respiratory dysfunction in amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The human CYP1A2 gene and induction by 3-methylcholanthrene. A region of DNA that supports AH-receptor binding and promoter-specific induction

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Can neurotrophic factors prevent or reverse motoneuron injury in amyotrophic lateral sclerosis?

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacology and mechanism of action of riluzole

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Riluzole: a new agent for amyotrophic lateral sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Population pharmacokinetics of riluzole in patients with amyotrophic lateral sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single- and multiple-dose pharmacokinetics of riluzole in white subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison of the pharmacokinetics and tolerability of riluzole after repeat dose administration in healthy elderly and young volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inter- and intraindividual variability of riluzole serum concentrations in patients with ALS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Riluzole serum concentrations in patients with ALS: associations with side effects and symptoms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of P-glycoprotein inhibition by excipients and their combinations using an integrated high-throughput process

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association between CYP1A2 activity and riluzole clearance in patients with amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of riluzole: evidence for glucuronidation as a major metabolic pathway not associated with UGT1A1 genotype.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of riluzole on neurological, brain biochemical, and histological changes in early and late term of sepsis in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions between riluzole and ABCG2/BCRP transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain and plasma riluzole pharmacokinetics: effect of minocycline combination

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-targeted solid lipid nanoparticles containing riluzole: preparation, characterization and biodistribution

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel administration route of edaravone--II: mucosal absorption of edaravone from edaravone/hydroxypropyl-beta-cyclodextrin complex solution including L-cysteine and sodium hydrogen sulfite

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic interaction between puerarin and edaravone, and effect of borneol on the brain distribution kinetics of puerarin in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Riluzole pharmacokinetics in young patients with spinal muscular atrophy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucuronidation of edaravone by human liver and kidney microsomes: biphasic kinetics and identification of UGT1A9 as the major UDP-glucuronosyltransferase isoform

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I clinical study of edaravone in healthy Chinese volunteers: safety and pharmacokinetics of single or multiple intravenous infusions

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacology of riluzole in acute spinal cord injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of cytochrome P450 enzymes: a view on human in vivo findings

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effects of edaravone on cognitive deficit, oxidative stress and tau hyperphosphorylation induced by intracerebroventricular streptozotocin in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety, tolerability and pharmacokinetics of MCI-186 in patients with acute ischemic stroke: new formulation and dosing regimen

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydroxypropyl-sulfobutyl-β-cyclodextrin improves the oral bioavailability of edaravone by modulating drug efflux pump of enterocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Study on the interaction of plasma protein binding rate between edaravone and taurine in human plasma based on HPLC analysis coupled with ultrafiltration technique

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ALS: A bucket of genes, environment, metabolism and unknown ingredients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of a novel oral delivery system of edaravone for enhancing bioavailability

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic Potential and Utility of Elacridar with Respect to P-glycoprotein Inhibition: An Insight from the Published In Vitro, Preclinical and Clinical Studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ALS Clinical Trials Review: 20 Years of Failure. Are We Any Closer to Registering a New Treatment?

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Edaravone-Encapsulated Agonistic Micelles Rescue Ischemic Brain Tissue by Tuning Blood-Brain Barrier Permeability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical efficacy of edaravone for the treatment of amyotrophic lateral sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid-based nanosystem of edaravone: development, optimization, characterization and in vitro/in vivo evaluation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blood-Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic profile of edaravone: a comparison between Japanese and Caucasian populations

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Edaravone: A new drug approved for ALS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29682695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S40262-018-0655-4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29682695%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29682695%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

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