Characterization of 3 Novel Tau Radiopharmaceuticals, 11C-RO-963, 11C-RO-643, and 18F-RO-948, in Healthy Controls and in Alzheimer Subjects (Q88574025)

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25 March 2020

title

Characterization of 3 Novel Tau Radiopharmaceuticals, 11C-RO-963, 11C-RO-643, and 18F-RO-948, in Healthy Controls and in Alzheimer Subjects (English)

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Constantine G. Lyketsos

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object named as

Constantine G Lyketsos

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Susan M Resnick

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Robert F Dannals

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Dean F Wong

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Luca Gobbi

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Ayon Nandi

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Hiroto Kuwabara

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James Brasic

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Susanne Ostrowitzki

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Lorena Gapasin

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Edilio Borroni

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Kelly Kitzmiller

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Chakradhar Mishra

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Marilyn Albert

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author name string

Paul B Rosenberg

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Cristina Vozzi

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Frank Boess

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Esther Oh

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Michael Honer

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Gregory Klein

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Noble George

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Josh Roberts

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Jeff Sevigny

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Madhav Thambisetty

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Abhay Mogekar

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Anil Mathur

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language of work or name

English

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publication date

4 May 2018

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The Journal of Nuclear Medicine

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published in

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volume

59

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issue

12

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page(s)

1869-1876

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Neuropathological stageing of Alzheimer-related changes

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cites work

1 reference

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Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry

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Visual assessment versus quantitative assessment of 11C-PIB PET and 18F-FDG PET for detection of Alzheimer's disease

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Tau imaging in the study of ageing, Alzheimer's disease, and other neurodegenerative conditions.

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Tau-Directed Immunotherapy: A Promising Strategy for Treating Alzheimer's Disease and Other Tauopathies

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Regional profiles of the candidate tau PET ligand 18F-AV-1451 recapitulate key features of Braak histopathological stages.

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PET Imaging of Tau Deposition in the Aging Human Brain.

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Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease.

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Discovery of 6-(Fluoro-(18)F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([(18)F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs).

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Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles.

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In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum.

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Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer's Disease

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Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition

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Preclinical Evaluation of 18F-JNJ64349311, a Novel PET Tracer for Tau Imaging

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Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

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Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer's Disease with Positron Emission Tomography.

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Correlations of (18)F-THK5351 PET with post-mortem burden of tau and astrogliosis in Alzheimer's disease.

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Preclinical Evaluation of (18)F-RO6958948, (11)C-RO6931643 and (11)C-RO6924963 as Novel Radiotracers for Imaging Aggregated Tau in AD with Positron Emission Tomography

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Evaluation of 18F-RO-948 PET for Quantitative Assessment of Tau Accumulation in the Human Brain.

1 reference

12 December 2020

10.2967/JNUMED.118.209916

Identifiers

DOI

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PubMed publication ID

29728519

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