OncoKB: A Precision Oncology Knowledge Base (Q88952320)

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29 March 2020

title

OncoKB: A Precision Oncology Knowledge Base (English)

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30

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23

Mrinal Gounder

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29 March 2020

author name string

Debyani Chakravarty

1

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29 March 2020

Jianjiong Gao

2

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29 March 2020

Sarah M Phillips

3

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29 March 2020

Ritika Kundra

4

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29 March 2020

Hongxin Zhang

5

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29 March 2020

Jiaojiao Wang

6

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29 March 2020

Julia E Rudolph

7

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29 March 2020

Rona Yaeger

8

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29 March 2020

Tara Soumerai

9

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29 March 2020

Moriah H Nissan

10

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29 March 2020

Matthew T Chang

11

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29 March 2020

Sarat Chandarlapaty

12

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29 March 2020

Tiffany A Traina

13

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29 March 2020

Paul K Paik

14

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29 March 2020

Alan L Ho

15

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29 March 2020

Feras M Hantash

16

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29 March 2020

Andrew Grupe

17

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29 March 2020

Shrujal S Baxi

18

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29 March 2020

Margaret K Callahan

19

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29 March 2020

Alexandra Snyder

20

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29 March 2020

Ping Chi

21

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29 March 2020

Daniel Danila

22

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29 March 2020

James J Harding

24

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29 March 2020

Matthew D Hellmann

25

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29 March 2020

Gopa Iyer

26

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29 March 2020

Yelena Janjigian

27

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29 March 2020

Thomas Kaley

28

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29 March 2020

Douglas A Levine

29

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29 March 2020

Antonio Omuro

31

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29 March 2020

Michael A Postow

32

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29 March 2020

Dana Rathkopf

33

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29 March 2020

Alexander N Shoushtari

34

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29 March 2020

Neerav Shukla

35

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29 March 2020

Martin Voss

36

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29 March 2020

Ederlinda Paraiso

37

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29 March 2020

Ahmet Zehir

38

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29 March 2020

Michael F Berger

39

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29 March 2020

Barry S Taylor

40

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29 March 2020

Leonard B Saltz

41

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29 March 2020

Gregory J Riely

42

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29 March 2020

Marc Ladanyi

43

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29 March 2020

David M Hyman

44

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29 March 2020

José Baselga

45

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29 March 2020

Paul Sabbatini

46

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29 March 2020

David B Solit

47

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29 March 2020

Nikolaus Schultz

48

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29 March 2020

publication date

16 May 2017

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29 March 2020

volume

2017

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Prevalence of off-label use and spending in 2010 among patent-protected chemotherapies in a population-based cohort of medical oncologists

29 March 2020

cites work

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12 December 2020

Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer

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12 December 2020

KRAS mutant lung cancer cells are differentially responsive to MEK inhibitor due to AKT or STAT3 activation: implication for combinatorial approach

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The clinical trial landscape in oncology and connectivity of somatic mutational profiles to targeted therapies

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Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background

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Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer.

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Predicting everolimus treatment efficacy in patients with advanced endometrial carcinoma: a GINECO group study.

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Study Design and Rationale for a Randomized, Placebo-Controlled, Double-Blind Study to Assess the Efficacy and Safety of Selumetinib in Combination With Docetaxel as Second-Line Treatment in Patients With KRAS-Mutant Advanced Non-Small Cell Lung Can

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Targeted Therapy for Patients with BRAF-Mutant Lung Cancer: Results from the European EURAF Cohort

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A Phase I Trial of BKM120 (Buparlisib) in Combination with Fulvestrant in Postmenopausal Women with Estrogen Receptor-Positive Metastatic Breast Cancer

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NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology.

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12 December 2020

Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence

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12 December 2020

ROS1 rearrangements define a unique molecular class of lung cancers

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Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma

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12 December 2020

Trastuzumab in the treatment of advanced non-small-cell lung cancer: is there a role? Focus on Eastern Cooperative Oncology Group study 2598.

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12 December 2020

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

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Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer

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Comprehensive molecular profiling of lung adenocarcinoma

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Phase II study of the MEK1/MEK2 inhibitor Trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor

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Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial

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Epidermal growth factor receptor exon 20 insertions in advanced lung adenocarcinomas: Clinical outcomes and response to erlotinib

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A decision support framework for genomically informed investigational cancer therapy

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Activating HER2 mutations in HER2 gene amplification negative breast cancer

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Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study

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The cancer precision medicine knowledge base for structured clinical-grade mutations and interpretations

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Comprehensive molecular portraits of human breast tumours

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12 December 2020

Microsatellite instability, mismatch repair deficiency, and BRAF mutation in treatment-resistant germ cell tumors.

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12 December 2020

Cancer Driver Log (CanDL): Catalog of Potentially Actionable Cancer Mutations

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12 December 2020

AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer

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12 December 2020

Discovery and saturation analysis of cancer genes across 21 tumour types

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12 December 2020

Impact of Precision Medicine in Diverse Cancers: A Meta-Analysis of Phase II Clinical Trials

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12 December 2020

PTEN loss does not predict for response to RAD001 (Everolimus) in a glioblastoma orthotopic xenograft test panel

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12 December 2020

Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF-Mutated Colorectal Cancer

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12 December 2020

Use of archived specimens in evaluation of prognostic and predictive biomarkers

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12 December 2020

Comprehensive molecular characterization of gastric adenocarcinoma

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12 December 2020

Pilot trial of combined BRAF and EGFR inhibition in BRAF-mutant metastatic colorectal cancer patients

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12 December 2020

International network of cancer genome projects

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12 December 2020

Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models

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12 December 2020

Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations

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12 December 2020

Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology

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12 December 2020

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

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12 December 2020

CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer

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12 December 2020

c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions

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12 December 2020

Going off-label without venturing off-course: evidence and ethical off-label prescribing.

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12 December 2020

p53 as a target for anti-cancer drug development.

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12 December 2020

Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies.

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12 December 2020

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

1 reference

12 December 2020

Phase I dose-escalation and -expansion study of buparlisib (BKM120), an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors

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12 December 2020

Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs

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12 December 2020

Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

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12 December 2020

Phase II trial of temsirolimus in patients with metastatic breast cancer

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12 December 2020

Regulatory actions on the off-label use of prescription drugs: ongoing controversy and contradiction in 2009 and 2010.

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12 December 2020

The Cancer Genome Atlas Pan-Cancer analysis project

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12 December 2020

Comprehensive molecular characterization of human colon and rectal cancer

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12 December 2020

Personalized medicine for patients with advanced cancer in the phase I program at MD Anderson: validation and landmark analyses

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12 December 2020

Tumors with AKT1E17K Mutations Are Rational Targets for Single Agent or Combination Therapy with AKT Inhibitors

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12 December 2020

BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors

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12 December 2020

Dabrafenib plus trametinib in patients with previously treated BRAF(V600E)-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial

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12 December 2020

Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600-Mutant Colorectal Cancer.

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12 December 2020

Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors

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12 December 2020

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

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12 December 2020

RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors

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12 December 2020

ROS1 as a 'druggable' receptor tyrosine kinase: lessons learned from inhibiting the ALK pathway

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12 December 2020

Guidelines for investigating causality of sequence variants in human disease

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12 December 2020

Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping

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12 December 2020

Activity of trametinib in K601E and L597Q BRAF mutation-positive metastatic melanoma

1 reference

12 December 2020

Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer

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12 December 2020

Tumor marker utility grading system: a framework to evaluate clinical utility of tumor markers

1 reference

12 December 2020

BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition

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12 December 2020

Mutational analysis of the BRAF gene in transitional cell carcinoma of the bladder.

1 reference

12 December 2020

Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas.

1 reference

12 December 2020

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

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12 December 2020

PD-L1 Expression and Tumor-Infiltrating Lymphocytes Define Different Subsets of MAPK Inhibitor-Treated Melanoma Patients.

1 reference

12 December 2020

Current advances in targeted therapies for metastatic gastric cancer: improving patient care

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12 December 2020

Drugging the p53 pathway: understanding the route to clinical efficacy

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12 December 2020

p53-based cancer therapy

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12 December 2020

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

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12 December 2020

Physicians' attitudes about multiplex tumor genomic testing

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12 December 2020

Identifiers

DOI

10.1200/PO.17.00011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28890946%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

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29 March 2020

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