Morin Mitigates Chronic Constriction Injury (CCI)-Induced Peripheral Neuropathy by Inhibiting Oxidative Stress Induced PARP Over-Activation and Neuroinflammation (Q89207049)

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scientific article published on 15 April 2016

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English	Morin Mitigates Chronic Constriction Injury (CCI)-Induced Peripheral Neuropathy by Inhibiting Oxidative Stress Induced PARP Over-Activation and Neuroinflammation	scientific article published on 15 April 2016

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scholarly article

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1 April 2020

Morin Mitigates Chronic Constriction Injury (CCI)-Induced Peripheral Neuropathy by Inhibiting Oxidative Stress Induced PARP Over-Activation and Neuroinflammation (English)

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1 April 2020

peripheral neuropathy

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author name string

Prashanth Komirishetty

1

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1 April 2020

Aparna Areti

2

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1 April 2020

Ramakrishna Sistla

3

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1 April 2020

Ashutosh Kumar

4

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publication date

15 April 2016

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Neurochemical Research

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1 April 2020

41

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1 April 2020

2029-2042

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8

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1 April 2020

Effect of morin on tissue lipid peroxidation and antioxidant status in 1, 2-dimethylhydrazine induced experimental colon carcinogenesis.

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https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

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Differential effect of spironolactone in chronic constriction injury and vincristine-induced neuropathic pain in rats

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12 December 2020

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Oxidative stress and nerve damage: role in chemotherapy induced peripheral neuropathy

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https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

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Flavonoid, morin inhibits oxidative stress, inflammation and enhances neurotrophic support in the brain of streptozotocin-induced diabetic rats.

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https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

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Both motor and sensory abnormalities contribute to changes in foot posture in an experimental rat neuropathic model.

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https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

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Fisetin Imparts Neuroprotection in Experimental Diabetic Neuropathy by Modulating Nrf2 and NF-κB Pathways

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https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

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Role of poly(ADP-ribose) polymerase activation in diabetic neuropathy

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https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Ameliorative effects of amiloride and pralidoxime in chronic constriction injury and vincristine induced painful neuropathy in rats

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https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

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Aloperine attenuated neuropathic pain induced by chronic constriction injury via anti-oxidation activity and suppression of the nuclear factor kappa B pathway

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https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Morin protects gastric mucosa from nonsteroidal anti-inflammatory drug, indomethacin induced inflammatory damage and apoptosis by modulating NF-κB pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Involvement of spinal microglia and interleukin-18 in the anti-nociceptive effect of dexmedetomidine in rats subjected to CCI.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

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PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration

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https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

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Further evidence for 'pain-related' behaviours in a model of unilateral peripheral mononeuropathy

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https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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A novel and selective poly (ADP-ribose) polymerase inhibitor ameliorates chemotherapy-induced painful neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Nociceptive behavior in animal models for peripheral neuropathy: spinal and supraspinal mechanisms

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https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

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Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Attenuation of mechanical but not thermal hyperalgesia by electroacupuncture with the involvement of opioids in rat model of chronic inflammatory pain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Roles of reactive oxygen and nitrogen species in pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Functional evaluation of peripheral nerve regeneration in the rat: walking track analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

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Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and cox-2 in a rat model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

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Murine models of human neuropathic pain

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https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

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Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

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NF-kappaB inhibitory action of resveratrol: a probable mechanism of neuroprotection in experimental diabetic neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Lack of evidence for significant neuronal loss in laminae I-III of the spinal dorsal horn of the rat in the chronic constriction injury model

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Morin modulates the oxidative stress-induced NF-kappaB pathway through its anti-oxidant activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Mechanisms of neuropathic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

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Atorvastatin attenuates neuropathic pain in rat neuropathy model by down-regulating oxidative damage at peripheral, spinal and supraspinal levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

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Protective role of morin, a flavonoid, against high glucose induced oxidative stress mediated apoptosis in primary rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

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Spinal NF-kB activation induces COX-2 upregulation and contributes to inflammatory pain hypersensitivity

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https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

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Hydroalcoholic extract of red propolis promotes functional recovery and axon repair after sciatic nerve injury in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

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Chronic restraint stress induces mechanical and cold allodynia, and enhances inflammatory pain in rat: Relevance to human stress-associated painful pathologies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Protective effects of 4-amino1,8-napthalimide, a poly (ADP-ribose) polymerase inhibitor in experimental diabetic neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroinflammation and oxidative stress in diabetic neuropathy: futuristic strategies based on these targets.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Assessment of oxidative parameters in rat spinal cord after chronic constriction of the sciatic nerve

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

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Behavioural pain-related disorders and contribution of the saphenous nerve in crush and chronic constriction injury of the rat sciatic nerve.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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A critical role of SRC-suppressed C kinase substrate in rat astrocytes after chronic constriction injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Inhibition of ROS-induced p38MAPK and ERK activation in microglia by acupuncture relieves neuropathic pain after spinal cord injury in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morin ameliorates chemically induced liver fibrosis in vivo and inhibits stellate cell proliferation in vitro by suppressing Wnt/β-catenin signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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The up-regulation of IL-6 in DRG and spinal dorsal horn contributes to neuropathic pain following L5 ventral root transection

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morin sulfates/glucuronides exert anti-inflammatory activity on activated macrophages and decreased the incidence of septic shock.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Nrf2 and NF-κB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic effects of polyphenols and methylxanthines with Leucine on AMPK/Sirtuin-mediated metabolism in muscle cells and adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Neuroprotective effect of saponin rich extract of Acorus calamus L. in rat model of chronic constriction injury (CCI) of sciatic nerve-induced neuropathic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Nitric oxide and its modulators in chronic constriction injury-induced neuropathic pain in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of neuropathic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathic pain modifies antioxidant activity in rat spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of neuronal nitric oxide synthase in the antiallodynic effects of intrathecal EGCG in a neuropathic pain rat model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The evidence for pharmacological treatment of neuropathic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased expression and role of GRK6 in spinal cord of rats after chronic constriction injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Morin Induces Heme Oxygenase-1 via ERK-Nrf2 Signaling Pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Intrathecal implants of bovine chromaffin cells alleviate mechanical allodynia in a rat model of neuropathic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

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Tumor necrosis factor receptor 1 induces interleukin-6 upregulation through NF-kappaB in a rat neuropathic pain model

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential Therapeutic Benefits of Maintaining Mitochondrial Health in Peripheral Neuropathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathy-induced apoptosis: protective effect of physostigmine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathobiology of neuropathic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms of neuroprotection by two natural antioxidant polyphenols

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective potential of combination of resveratrol and 4-amino 1,8 naphthalimide in experimental diabetic neuropathy: focus on functional, sensorimotor and biochemical changes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of reactive oxygen species and spinal cord apoptotic genes in the development of neuropathic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of oxidative stress in pathophysiology of peripheral neuropathy and modulation by N-acetyl-L-cysteine in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genistein, a natural phytoestrogen from soy, relieves neuropathic pain following chronic constriction sciatic nerve injury in mice: anti-inflammatory and antioxidant activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of N-acetylcysteine on the spinal-cord glutathione system and nitric-oxide metabolites in rats with neuropathic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PARP inhibition attenuates neuroinflammation and oxidative stress in chronic constriction injury induced peripheral neuropathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27084773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11064-016-1914-0

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27084773%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27084773%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

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