Conceptual Model of Biofilm Antibiotic Tolerance That Integrates Phenomena of Diffusion, Metabolism, Gene Expression, and Physiology (Q90001348)

PubMed publication ID

31501280

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31501280%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

title

Conceptual Model of Biofilm Antibiotic Tolerance That Integrates Phenomena of Diffusion, Metabolism, Gene Expression, and Physiology (English)

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12 May 2020

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1

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12 May 2020

Anders Wallqvist

11

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12 May 2020

author name string

Ben White

2

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12 May 2020

Laura Boegli

3

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12 May 2020

Timothy Hamerly

4

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12 May 2020

Kerry S Williamson

5

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12 May 2020

Michael J Franklin

6

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12 May 2020

Brian Bothner

7

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12 May 2020

Garth A James

8

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12 May 2020

Steve Fisher

9

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12 May 2020

Francisco G Vital-Lopez

10

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12 May 2020

publication date

21 October 2019

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PubMed publication ID

31501280

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31501280%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

published in

Journal of Bacteriology

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12 May 2020

volume

201

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12 May 2020

issue

22

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A model of substrate utilization by bacterial films

12 May 2020

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Simple biochemical markers to assess chronic wounds

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Alginate overproduction affects Pseudomonas aeruginosa biofilm structure and function

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Gene expression in Pseudomonas aeruginosa biofilms

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Biofilms and planktonic cells of Pseudomonas aeruginosa have similar resistance to killing by antimicrobials

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Evidence of oxidative stress in chronic venous ulcers

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Oxygen limitation contributes to antibiotic tolerance of Pseudomonas aeruginosa in biofilms.

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Long-term anaerobic survival of the opportunistic pathogen Pseudomonas aeruginosa via pyruvate fermentation

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Stratified growth in Pseudomonas aeruginosa biofilms

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Adaptive responses to antimicrobial agents in biofilms.

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Effect of oxygen limitation on the in vitro antimicrobial susceptibility of clinical isolates of Pseudomonas aeruginosa grown planktonically and as biofilms.

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12 December 2020

Anaerobic survival of Pseudomonas aeruginosa by pyruvate fermentation requires an Usp-type stress protein

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ppGpp: stringent response and survival.

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12 December 2020

A distinct QscR regulon in the Pseudomonas aeruginosa quorum-sensing circuit

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12 December 2020

Infected chronic wounds show different local and systemic arginine conversion compared with acute wounds

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12 December 2020

Quorum-sensing antagonistic activities of azithromycin in Pseudomonas aeruginosa PAO1: a global approach.

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12 December 2020

Clustering of Pseudomonas aeruginosa transcriptomes from planktonic cultures, developing and mature biofilms reveals distinct expression profiles

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12 December 2020

Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin

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12 December 2020

Survival and growth in the presence of elevated copper: transcriptional profiling of copper-stressed Pseudomonas aeruginosa

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12 December 2020

Biochemical analysis of wound fluid from nonhealing and healing chronic leg ulcers

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12 December 2020

Membrane-bound nitrate reductase is required for anaerobic growth in cystic fibrosis sputum

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12 December 2020

Pyocyanin alters redox homeostasis and carbon flux through central metabolic pathways in Pseudomonas aeruginosa PA14.

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12 December 2020

Responses of Pseudomonas aeruginosa to low oxygen indicate that growth in the cystic fibrosis lung is by aerobic respiration

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12 December 2020

Physiological heterogeneity in biofilms

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12 December 2020

Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB-oprM genes

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12 December 2020

Comparing insertion libraries in two Pseudomonas aeruginosa strains to assess gene essentiality

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12 December 2020

Involvement of a novel efflux system in biofilm-specific resistance to antibiotics

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12 December 2020

A multispecies biofilm model.

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12 December 2020

Quantitative analysis of biofilm thickness variability

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12 December 2020

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

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12 December 2020

Biofilms and type III secretion are not mutually exclusive in Pseudomonas aeruginosa.

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12 December 2020

A method for growing a biofilm under low shear at the air-liquid interface using the drip flow biofilm reactor

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12 December 2020

Genetic and biochemical analyses of the Pseudomonas aeruginosa Psl exopolysaccharide reveal overlapping roles for polysaccharide synthesis enzymes in Psl and LPS production

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12 December 2020

Targeting a bacterial stress response to enhance antibiotic action

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12 December 2020

Effect of oxygen limitation on the in vitro activity of levofloxacin and other antibiotics administered by the aerosol route against Pseudomonas aeruginosa from cystic fibrosis patients

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12 December 2020

Endogenous phenazine antibiotics promote anaerobic survival of Pseudomonas aeruginosa via extracellular electron transfer

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12 December 2020

Nutrient availability as a mechanism for selection of antibiotic tolerant Pseudomonas aeruginosa within the CF airway

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12 December 2020

Real-time microsensor measurement of local metabolic activities in ex vivo dental biofilms exposed to sucrose and treated with chlorhexidine

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12 December 2020

What is flux balance analysis?

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12 December 2020

Anaerobic adaptation in Pseudomonas aeruginosa: definition of the Anr and Dnr regulons

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12 December 2020

How Pseudomonas aeruginosa adapts to various environments: a metabolomic approach

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12 December 2020

Pseudomonas aeruginosa biofilm matrix polysaccharide Psl is regulated transcriptionally by RpoS and post-transcriptionally by RsmA

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12 December 2020

Anaerobic physiology of Pseudomonas aeruginosa in the cystic fibrosis lung

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12 December 2020

Physiology of Pseudomonas aeruginosa in biofilms as revealed by transcriptome analysis.

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12 December 2020

The pel polysaccharide can serve a structural and protective role in the biofilm matrix of Pseudomonas aeruginosa.

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12 December 2020

The stringent response is essential for Pseudomonas aeruginosa virulence in the rat lung agar bead and Drosophila melanogaster feeding models of infection

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12 December 2020

In-vivo expression profiling of Pseudomonas aeruginosa infections reveals niche-specific and strain-independent transcriptional programs.

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12 December 2020

Biosynthesis of the Pseudomonas aeruginosa Extracellular Polysaccharides, Alginate, Pel, and Psl

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12 December 2020

Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria

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12 December 2020

Discovery of a biofilm electrocline using real-time 3D metabolite analysis

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12 December 2020

The metabolically active subpopulation in Pseudomonas aeruginosa biofilms survives exposure to membrane-targeting antimicrobials via distinct molecular mechanisms

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12 December 2020

Hypoxia increases antibiotic resistance in Pseudomonas aeruginosa through altering the composition of multidrug efflux pumps

1 reference

12 December 2020

Heterogeneity in Pseudomonas aeruginosa biofilms includes expression of ribosome hibernation factors in the antibiotic-tolerant subpopulation and hypoxia-induced stress response in the metabolically active population

1 reference

12 December 2020

Synthesis of multiple Pseudomonas aeruginosa biofilm matrix exopolysaccharides is post-transcriptionally regulated

1 reference

12 December 2020

The MerR-like transcriptional regulator BrlR contributes to Pseudomonas aeruginosa biofilm tolerance

1 reference

12 December 2020

Microcolony formation by the opportunistic pathogen Pseudomonas aeruginosa requires pyruvate and pyruvate fermentation

1 reference

12 December 2020

The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms

1 reference

12 December 2020

Self-produced exopolysaccharide is a signal that stimulates biofilm formation in Pseudomonas aeruginosa.

1 reference

12 December 2020

Bacterial community morphogenesis is intimately linked to the intracellular redox state

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12 December 2020

Starvation, together with the SOS response, mediates high biofilm-specific tolerance to the fluoroquinolone ofloxacin.

1 reference

12 December 2020

AmrZ modulates Pseudomonas aeruginosa biofilm architecture by directly repressing transcription of the psl operon

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12 December 2020

The stringent response controls catalases in Pseudomonas aeruginosa and is required for hydrogen peroxide and antibiotic tolerance

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12 December 2020

The MerR-like regulator BrlR confers biofilm tolerance by activating multidrug efflux pumps in Pseudomonas aeruginosa biofilms

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12 December 2020

The extracellular matrix protects Pseudomonas aeruginosa biofilms by limiting the penetration of tobramycin

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12 December 2020

Bacterial biofilm development as a multicellular adaptation: antibiotic resistance and new therapeutic strategies.

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12 December 2020

The extracellular matrix Component Psl provides fast-acting antibiotic defense in Pseudomonas aeruginosa biofilms

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12 December 2020

Bactericidal effect of colistin on planktonic Pseudomonas aeruginosa is independent of hydroxyl radical formation

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12 December 2020

Morphological optimization for access to dual oxidants in biofilms

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12 December 2020

Formation of hydroxyl radicals contributes to the bactericidal activity of ciprofloxacin against Pseudomonas aeruginosa biofilms

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12 December 2020

General theory for integrated analysis of growth, gene, and protein expression in biofilms

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12 December 2020

Nitric oxide production by polymorphonuclear leucocytes in infected cystic fibrosis sputum consumes oxygen

1 reference

12 December 2020

Phenazine redox cycling enhances anaerobic survival in Pseudomonas aeruginosa by facilitating generation of ATP and a proton-motive force

1 reference

12 December 2020

Transposon mutagenesis

1 reference

12 December 2020

Polymorphonuclear leukocytes restrict growth of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients

1 reference

12 December 2020

Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum

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12 December 2020

Contribution of stress responses to antibiotic tolerance in Pseudomonas aeruginosa biofilms

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12 December 2020

Antimicrobial Tolerance in Biofilms

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12 December 2020

Pediatric Cystic Fibrosis Sputum Can Be Chemically Dynamic, Anoxic, and Extremely Reduced Due to Hydrogen Sulfide Formation

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12 December 2020

Untargeted metabolomics studies employing NMR and LC-MS reveal metabolic coupling between Nanoarcheum equitans and its archaeal host Ignicoccus hospitalis.

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12 December 2020

ZnuA and zinc homeostasis in Pseudomonas aeruginosa

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12 December 2020

Biofilm Formation Mechanisms of Pseudomonas aeruginosa Predicted via Genome-Scale Kinetic Models of Bacterial Metabolism

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12 December 2020

Enhanced annotations and features for comparing thousands of Pseudomonas genomes in the Pseudomonas genome database.

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12 December 2020

Microsensor and transcriptomic signatures of oxygen depletion in biofilms associated with chronic wounds

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12 December 2020

Identification of a small molecule that simultaneously suppresses virulence and antibiotic resistance of Pseudomonas aeruginosa

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12 December 2020

SutA is a bacterial transcription factor expressed during slow growth in Pseudomonas aeruginosa

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12 December 2020

RNASeq Based Transcriptional Profiling of Pseudomonas aeruginosa PA14 after Short- and Long-Term Anoxic Cultivation in Synthetic Cystic Fibrosis Sputum Medium

1 reference

12 December 2020

Role of Glyoxylate Shunt in Oxidative Stress Response

1 reference

12 December 2020

Pseudomonas aeruginosa AmrZ Binds to Four Sites in the algD Promoter, Inducing DNA-AmrZ Complex Formation and Transcriptional Activation

1 reference

12 December 2020

Evaluating the Effect of Oxygen Concentrations on Antibiotic Sensitivity, Growth, and Biofilm Formation of Human Pathogens

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12 December 2020

Hyperosmotic Agents and Antibiotics Affect Dissolved Oxygen and pH Concentration Gradients in Staphylococcus aureus Biofilms

1 reference

12 December 2020

Carbon Sources Tune Antibiotic Susceptibility in Pseudomonas aeruginosa via Tricarboxylic Acid Cycle Control

1 reference

12 December 2020

Importance of the Exopolysaccharide Matrix in Antimicrobial Tolerance of Pseudomonas aeruginosa Aggregates

1 reference

12 December 2020

Role of psl Genes in Antibiotic Tolerance of Adherent Pseudomonas aeruginosa

1 reference

12 December 2020

Electron-shuttling antibiotics structure bacterial communities by modulating cellular levels of c-di-GMP.

1 reference

12 December 2020

Reaction-diffusion theory explains hypoxia and heterogeneous growth within microbial biofilms associated with chronic infections

1 reference

12 December 2020

Pseudomonas aeruginosa Proteome under Hypoxic Stress Conditions Mimicking the Cystic Fibrosis Lung.

1 reference

12 December 2020

Hyperbaric oxygen sensitizes anoxic Pseudomonas aeruginosa biofilm to ciprofloxacin

1 reference

12 December 2020

Selective Proteomic Analysis of Antibiotic-Tolerant Cellular Subpopulations in Pseudomonas aeruginosa Biofilms

1 reference

12 December 2020

An orphan cbb3-type cytochrome oxidase subunit supports Pseudomonas aeruginosa biofilm growth and virulence.

1 reference

12 December 2020

The ABC of biofilm drug tolerance: The MerR-like regulator BrlR is an activator of ABC transport systems, with PA1874-77 contributing to the tolerance by Pseudomonas aeruginosa biofilms to tobramycin

1 reference

12 December 2020

Identification of Fitness Determinants during Energy-Limited Growth Arrest in Pseudomonas aeruginosa

1 reference

12 December 2020

Structural and metabolic responses of Staphylococcus aureus biofilms to hyperosmotic and antibiotic stress.

1 reference

12 December 2020

The Yin and Yang of SagS: Distinct Residues in the HmsP Domain of SagS Independently Regulate Biofilm Formation and Biofilm Drug Tolerance.

1 reference

12 December 2020

The PA3177 Gene Encodes an Active Diguanylate Cyclase That Contributes to Biofilm Antimicrobial Tolerance but Not Biofilm Formation by Pseudomonas aeruginosa

1 reference

12 December 2020

High-resolution in situ transcriptomics of Pseudomonas aeruginosa unveils genotype independent patho-phenotypes in cystic fibrosis lungs

1 reference

12 December 2020

The Pseudomonas aeruginosa Complement of Lactate Dehydrogenases Enables Use of d- and l-Lactate and Metabolic Cross-Feeding

1 reference

12 December 2020

The SOS system: A complex and tightly regulated response to DNA damage

1 reference

12 December 2020

Detection of respiration changes inside biofilms with microelectrodes during exposure to antibiotics

1 reference

12 December 2020

Oxidative stress response plays a role in antibiotic tolerance of Streptococcus mutans biofilms

1 reference

12 December 2020

Pharmacodynamics of ciprofloxacin against Pseudomonas aeruginosa planktonic and biofilm-derived cells

1 reference

12 December 2020

Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms

1 reference

12 December 2020

Measuring Antimicrobial Efficacy against Biofilms: a Meta-analysis

1 reference

12 December 2020

Pyruvate-depleting conditions induce biofilm dispersion and enhance the efficacy of antibiotics in killing biofilms in vitro and in vivo

1 reference

12 December 2020

Bacterial fitness in chronic wounds appears to be mediated by the capacity for high-density growth, not virulence or biofilm functions

1 reference

12 December 2020

Treatment with the Pseudomonas aeruginosa Glycoside Hydrolase PslG Combats Wound Infection by Improving Antibiotic Efficacy and Host Innate Immune Activity

1 reference

12 December 2020

In Vivo Proteome of Pseudomonas aeruginosa in Airways of Cystic Fibrosis Patients

1 reference

12 December 2020

Tolerance and Resistance of Pseudomonas aeruginosa Biofilms to Antimicrobial Agents—How P. aeruginosa Can Escape Antibiotics

1 reference

12 December 2020

Non-invasive imaging of oxygen concentration in a complex in vitro biofilm infection model using 19 F MRI: Persistence of an oxygen sink despite prolonged antibiotic therapy

1 reference

12 December 2020

Identifiers

DOI

10.1128/JB.00307-19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6805107&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6805107&resulttype=core&format=json

12 May 2020

PubMed publication ID

31501280

1 reference