BCR activator of RhoGEF and GTPase (Q903924)

Rho GTPase activation protein

1 reference

Dbl homology (DH) domain superfamily

1 reference

Bcr-Abl oncoprotein oligomerisation domain superfamily

1 reference

Abr/Bcr

1 reference

pleckstrin homology domain, protein family

1 reference

Bcr-Abl oncoprotein oligomerisation, protein family

1 reference

C2 domain, protein family

1 reference

Rho GTPase-activating protein domain family

1 reference

Dbl homology (DH) domain, protein family

1 reference

Guanine-nucleotide dissociation stimulator, CDC24, conserved site, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

1 reference

9 May 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

1 reference

9 May 2019

protein serine/threonine kinase activity

3 references

protein binding

12 references

9 May 2019

Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

9 May 2019

Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

9 May 2019

The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

9 May 2019

Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

9 May 2019

Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

9 May 2019

Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

9 May 2019

Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

9 May 2019

Bcr phosphorylated on tyrosine 177 binds Grb2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

9 May 2019

A human protein-protein interaction network: a resource for annotating the proteome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

9 May 2019

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

9 May 2019

The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

9 May 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

enzyme binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11274&geneProductId=UniProtKB:P11274

1 reference

1 January 2018

ATP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

1 reference

9 May 2019

GTPase activator activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11274&geneProductId=UniProtKB:P11274

6 references

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11274&geneProductId=UniProtKB:P11274

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11274&geneProductId=UniProtKB:P11274

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11274&geneProductId=UniProtKB:P11274

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11274&geneProductId=UniProtKB:P11274

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11274&geneProductId=UniProtKB:P11274

26 September 2017

GTPase activator activity

IBA

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

guanyl-nucleotide exchange factor activity

The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

9 May 2019

9 May 2019

Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

GTPase activator activity

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

9 May 2019

Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

cell component

cytoplasm

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

postsynaptic membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

1 reference

9 May 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11274&geneProductId=UniProtKB:P11274

3 references

26 September 2017

26 September 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11274&geneProductId=UniProtKB:P11274

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11274&geneProductId=UniProtKB:P11274

26 September 2017

IBA

postsynaptic density

ISS

synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

1 reference

9 May 2019

cell junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

1 reference

9 May 2019

extracellular exosome

1 reference

26 September 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11274&geneProductId=UniProtKB:P11274

protein-containing complex

1 reference

9 May 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

extracellular exosome

HDA

1 reference

9 May 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

Schaffer collateral - CA1 synapse

HDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

glutamatergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

postsynaptic density, intracellular component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

positive regulation of phagocytosis

biological process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

intracellular signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

1 reference

9 May 2019

neuromuscular process controlling balance

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

1 reference

9 May 2019

regulation of cell cycle

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

negative regulation of blood vessel remodeling

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

negative regulation of cellular extravasation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

response to lipopolysaccharide

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

brain development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

regulation of vascular permeability

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

negative regulation of cell migration

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

negative regulation of neutrophil degranulation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

inner ear morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

protein autophosphorylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

platelet-derived growth factor receptor signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

regulation of Rho protein signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

1 reference

8 April 2019

regulation of small GTPase mediated signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

1 reference

9 May 2019

negative regulation of inflammatory response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

actin cytoskeleton organization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

peptidyl-tyrosine phosphorylation

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11274&geneProductId=UniProtKB:P11274

renal system process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

homeostasis of number of cells

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

regulation of nitrogen compound metabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

definitive hemopoiesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

negative regulation of respiratory burst

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

intracellular protein transmembrane transport

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

cellular response to lipopolysaccharide

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

negative regulation of reactive oxygen species metabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

positive regulation of GTPase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11274&geneProductId=UniProtKB:P11274

1 reference

26 September 2017

positive regulation of GTPase activity

IBA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

1 reference

9 May 2019

modulation of chemical synaptic transmission

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

small GTPase mediated signal transduction

1 reference

9 May 2019

The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

keratinocyte differentiation

1 reference

9 May 2019

The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

focal adhesion assembly

1 reference

9 May 2019

The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274

activation of GTPase activity

has part(s)

Dbl homology (DH) domain

1 reference

pleckstrin homology domain

1 reference

Rho GTPase-activating protein domain

1 reference

Guanine-nucleotide dissociation stimulator, CDC24, conserved site

1 reference

Bcr-Abl oncoprotein oligomerisation

1 reference

C2 domain

1 reference

D08.811.913.696.620.682.700.759

Identifiers

MeSH descriptor ID

D051562

subject named as

Proto-Oncogene Proteins c-bcr

0 references

MeSH tree code

0 references

D12.644.360.325.300.099.500

0 references

D12.776.476.325.300.099.500

0 references

D12.776.476.563.759

0 references

D12.776.624.664.700.171

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

0 references

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

4 August 2016

language of work or name

1 reference

4 August 2016

language of work or name

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023