Prostaglandin I2 synthase (Q904590)

http://www.ebi.ac.uk/interpro/protein/Q16647

Prostacyclin synthase

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16647

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

monooxygenase activity

1 reference

8 April 2019

1 reference

8 April 2019

The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

prostaglandin-I synthase activity

5 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647

16 July 2018

The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647

16 July 2018

Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647

prostaglandin-I synthase activity

6 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647

10 September 2018

Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647

10 September 2018

The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

8 April 2019

Crystal structure of the human prostacyclin synthase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

prostaglandin-I synthase activity

IBA

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

8 April 2019

The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

8 April 2019

Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

integral component of membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

1 reference

8 April 2019

The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647

endoplasmic reticulum

3 references

16 July 2018

16 July 2018

Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis: mechanisms of COX-2 inhibitor risk to heart disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

ISS

endoplasmic reticulum

4 references

8 April 2019

8 April 2019

Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis: mechanisms of COX-2 inhibitor risk to heart disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

prostaglandin metabolic process

IBA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

positive regulation of execution phase of apoptosis

1 reference

8 April 2019

Prostacyclin-dependent apoptosis mediated by PPAR delta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

cellular response to interleukin-6

1 reference

8 April 2019

Molecular cloning and expression of human prostacyclin synthase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

icosanoid metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

TAS

cyclooxygenase pathway

1 reference

8 April 2019

fatty acid metabolic process

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

positive regulation of angiogenesis

1 reference

8 April 2019

The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

fatty acid biosynthetic process

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

negative regulation of nitric oxide biosynthetic process

1 reference

8 April 2019

Protection against cytokine toxicity through endoplasmic reticulum and mitochondrial stress prevention by prostacyclin synthase overexpression in insulin-producing cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

cellular response to interleukin-1

1 reference

8 April 2019

Molecular cloning and expression of human prostacyclin synthase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

positive regulation of peroxisome proliferator activated receptor signaling pathway

IEP

1 reference

8 April 2019

Prostacyclin-dependent apoptosis mediated by PPAR delta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

apoptotic signaling pathway

1 reference

8 April 2019

Prostacyclin-dependent apoptosis mediated by PPAR delta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

negative regulation of NF-kappaB transcription factor activity

1 reference

8 April 2019

Protection against cytokine toxicity through endoplasmic reticulum and mitochondrial stress prevention by prostacyclin synthase overexpression in insulin-producing cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

negative regulation of inflammatory response

1 reference

8 April 2019

Protection against cytokine toxicity through endoplasmic reticulum and mitochondrial stress prevention by prostacyclin synthase overexpression in insulin-producing cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

cellular response to hypoxia

1 reference

8 April 2019

Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

prostaglandin biosynthetic process

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647

16 July 2018

The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647

16 July 2018

Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647

NAD biosynthesis via nicotinamide riboside salvage pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

prostaglandin biosynthetic process

TAS

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

8 April 2019

The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

8 April 2019

Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647