NS5 from Dengue Virus Serotype 2 Can Adopt a Conformation Analogous to That of Its Zika Virus and Japanese Encephalitis Virus Homologues (Q90616747)

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15 April 2020

title

NS5 from Dengue Virus Serotype 2 Can Adopt a Conformation Analogous to That of Its Zika Virus and Japanese Encephalitis Virus Homologues (English)

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15 April 2020

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Japanese encephalitis

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Japanese encephalitis virus

object named as

Japanese Encephalitis Virus

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inferred from title

dengue virus protein NS5

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inferred from abstract

author

Abbas El Sahili

1

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15 April 2020

Siew Pheng Lim

7

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15 April 2020

6

Pei-Yong Shi

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15 April 2020

author name string

Tingjin Sherryl Soh

2

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15 April 2020

Jonas Schiltz

3

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15 April 2020

Aïcha Gharbi-Ayachi

4

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15 April 2020

Cheah Chen Seh

5

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15 April 2020

Julien Lescar

8

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15 April 2020

publication date

12 December 2019

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15 April 2020

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15 April 2020

volume

94

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15 April 2020

issue

1

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Flavivirus genome organization, expression, and replication

15 April 2020

cites work

1 reference

12 December 2020

An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization

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West Nile Virus 5'-Cap Structure Is Formed by Sequential Guanine N-7 and Ribose 2'-O Methylations by Nonstructural Protein 5

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West Nile Virus Methyltransferase Catalyzes Two Methylations of the Viral RNA Cap through a Substrate-Repositioning Mechanism

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Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2'-O methyltransferase activity in dengue virus

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Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER

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Dengue virus nonstructural protein 5 adopts multiple conformations in solution

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Molecular basis for nucleotide conservation at the ends of the dengue virus genome.

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12 December 2020

Conformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an Inhibitor

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12 December 2020

Crystal Structure of the full-length Japanese encephalitis virus NS5 reveals a conserved methyltransferase-polymerase interface

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12 December 2020

A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability and de Novo Initiation Activities

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12 December 2020

Polymerases of hepatitis C viruses and flaviviruses: structural and mechanistic insights and drug development

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12 December 2020

The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain

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12 December 2020

A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication

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12 December 2020

Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening

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12 December 2020

The dengue virus NS5 protein as a target for drug discovery

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12 December 2020

Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication

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12 December 2020

Structural insight and flexible features of NS5 proteins from all four serotypes of Dengue virus in solution

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12 December 2020

Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

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12 December 2020

Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface

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12 December 2020

The global economic burden of dengue: a systematic analysis

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12 December 2020

Zika virus: history of a newly emerging arbovirus

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12 December 2020

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

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12 December 2020

Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5.

1 reference

12 December 2020

Dengue Virus Non-Structural Protein 5

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12 December 2020

Dengue drug discovery: Progress, challenges and outlook

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12 December 2020

Supramolecular arrangement of the full-length Zika virus NS5

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12 December 2020