A statistical framework for cross-tissue transcriptome-wide association analysis (Q91908163)

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25 April 2020

title

A statistical framework for cross-tissue transcriptome-wide association analysis (English)

1 reference

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25 April 2020

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1

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25 April 2020

Qiongshi Lu

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25 April 2020

Seyedeh M Zekavat

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25 April 2020

Boyang Li

8

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25 April 2020

Brian W Kunkle

12

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25 April 2020

Pradeep Natarajan

14

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25 April 2020

Hongyu Zhao

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18

Paul K Crane

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25 April 2020

Shubhabrata Mukherjee

13

object named as

Shubhabrata Mukherjee

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Adam Naj

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25 April 2020

16

Amanda Kuzma

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25 April 2020

author name string

Mo Li

2

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25 April 2020

Haoyi Weng

4

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25 April 2020

Jiawei Wang

5

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25 April 2020

Zhaolong Yu

7

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25 April 2020

Jianlei Gu

9

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25 April 2020

Sydney Muchnik

10

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Yu Shi

11

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25 April 2020

Yi Zhao

17

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25 April 2020

Alzheimer’s Disease Genetics Consortium,

19

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Hui Lu

20

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publication date

25 February 2019

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25 April 2020

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25 April 2020

volume

51

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25 April 2020

issue

3

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25 April 2020

page(s)

568-576

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Probabilistic fine-mapping of transcriptome-wide association studies

25 April 2020

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23 February 2021

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23 February 2021

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A Powerful Framework for Integrating eQTL and GWAS Summary Data.

23 February 2021

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Applying meta-analysis to genotype-tissue expression data from multiple tissues to identify eQTLs and increase the number of eGenes

23 February 2021

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Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer's disease

23 February 2021

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23 February 2021

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A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.

23 February 2021

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An Expanded View of Complex Traits: From Polygenic to Omnigenic

23 February 2021

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Joint modeling of genetically correlated diseases and functional annotations increases accuracy of polygenic risk prediction

23 February 2021

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Cis-eQTL-based trans-ethnic meta-analysis reveals novel genes associated with breast cancer risk.

23 February 2021

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Functional Architectures of Local and Distal Regulation of Gene Expression in Multiple Human Tissues.

23 February 2021

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Integrating Gene Expression with Summary Association Statistics to Identify Genes Associated with 30 Complex Traits

23 February 2021

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Heritability and GWAS Studies for Monocyte-Lymphocyte Ratio

23 February 2021

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Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases

23 February 2021

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Case-control association mapping by proxy using family history of disease

23 February 2021

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Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.

23 February 2021

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Colocalization of GWAS and eQTL Signals Detects Target Genes

23 February 2021

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The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

23 February 2021

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Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells

23 February 2021

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Gene expression elucidates functional impact of polygenic risk for schizophrenia

23 February 2021

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23 February 2021

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23 February 2021

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23 February 2021

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23 February 2021

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23 February 2021

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23 February 2021

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Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.

23 February 2021

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Partitioning heritability by functional annotation using genome-wide association summary statistics

23 February 2021

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A gene-based association method for mapping traits using reference transcriptome data

23 February 2021

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Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

23 February 2021

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23 February 2021

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Integrative analysis of 111 reference human epigenomes

23 February 2021

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Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).

23 February 2021

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Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder

23 February 2021

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IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior.

23 February 2021

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Bayesian test for colocalisation between pairs of genetic association studies using summary statistics

23 February 2021

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Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes

23 February 2021

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Guilt by rewiring: gene prioritization through network rewiring in genome wide association studies.

23 February 2021

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Improving genetic risk prediction by leveraging pleiotropy

23 February 2021

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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

23 February 2021

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Discovery and refinement of loci associated with lipid levels

23 February 2021

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Transcriptome and genome sequencing uncovers functional variation in humans

23 February 2021

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Effectively identifying eQTLs from multiple tissues by combining mixed model and meta-analytic approaches

23 February 2021

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A statistical framework for joint eQTL analysis in multiple tissues

23 February 2021

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Genome-wide association study of the rate of cognitive decline in Alzheimer's disease

23 February 2021

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Polygenic modeling with bayesian sparse linear mixed models

23 February 2021

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An integrated map of genetic variation from 1,092 human genomes

23 February 2021

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Prazosin, an α(1)-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease

23 February 2021

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Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism

23 February 2021

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AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice

23 February 2021

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Complement receptor 1 (CR1) and Alzheimer's disease

23 February 2021

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Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

23 February 2021

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Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

23 February 2021

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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

23 February 2021

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From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

23 February 2021

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Biological, clinical and population relevance of 95 loci for blood lipids

23 February 2021

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LocusZoom: regional visualization of genome-wide association scan results

23 February 2021

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Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease

23 February 2021

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METAL: fast and efficient meta-analysis of genomewide association scans

23 February 2021

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A Bayesian framework to account for complex non-genetic factors in gene expression levels greatly increases power in eQTL studies

23 February 2021

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Genome-wide analysis of genetic loci associated with Alzheimer disease

23 February 2021

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Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS

23 February 2021

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Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

23 February 2021

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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

23 February 2021

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

23 February 2021

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A new multipoint method for genome-wide association studies by imputation of genotypes

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6788740

Warfarin dose related to apolipoprotein E (APOE) genotype

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6788740

Identification of the gene for vitamin K epoxide reductase

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6788740

Lithostathine and pancreatitis-associated protein are involved in the very early stages of Alzheimer's disease.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6788740

HT-eQTL: integrative expression quantitative trait loci analysis in a large number of human tissues.

23 February 2021

1 reference

https://api.crossref.org/works/10.1038%2FS41588-019-0345-7

7 January 2021

Model selection and estimation in regression with grouped variables

1 reference

https://api.crossref.org/works/10.1038%2FS41588-019-0345-7

7 January 2021

Transethnic genome-wide scan identifies novel Alzheimer's disease loci

1 reference

https://api.crossref.org/works/10.1038%2FS41588-019-0345-7

7 January 2021

The Rab GTPase family

1 reference

https://api.crossref.org/works/10.1038%2FS41588-019-0345-7

7 January 2021

Integrative cross tissue analysis of gene expression identifies novel type 2 diabetes genes

1 reference

https://api.crossref.org/works/10.1038%2FS41588-019-0345-7

7 January 2021

qqman: an R package for visualizing GWAS results using Q-Q and manhattan plots

1 reference

https://api.crossref.org/works/10.1038%2FS41588-019-0345-7

7 January 2021

10.1038/S41588-019-0345-7

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30804563%20AND%20SRC:MED&resulttype=core&format=json

25 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30804563%20AND%20SRC:MED&resulttype=core&format=json

25 April 2020

PubMed publication ID

30804563

1 reference