Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2 (Q95603892)

https://api.crossref.org/v1/works/http://dx.doi.org/10.1101/2020.05.18.102467

27 May 2020

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Host translation inhibitor nsp1 [SARS-CoV-2]

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based on heuristic

inferred from abstract

structural biology

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based on heuristic

inferred from abstract

evasion of host immune response

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based on heuristic

inferred from title

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Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

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author

Matthias Thoms

1

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27 May 2020

Robert Buschauer

2

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27 May 2020

Michael Ameismeier

3

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27 May 2020

Lennart Koepke

4

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27 May 2020

Hanna Kratzat

7

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27 May 2020

Jingdong Cheng

10

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Otto Berninghausen

13

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Konstantin Sparrer

16

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Roland Beckmann

17

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author name string

Timo Denk

5

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27 May 2020

Maximilian Hirschenberger

6

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27 May 2020

Manuel Hayn

8

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27 May 2020

Timur Mackens-Kiani

9

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27 May 2020

Christina M. Stürzel

11

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27 May 2020

Thomas Fröhlich

12

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Thomas Becker

14

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27 May 2020

Frank Kirchhoff

15

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27 May 2020

publication date

19 May 2020

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Attenuation of mouse hepatitis virus by deletion of the LLRKxGxKG region of Nsp1.

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Severe acute respiratory syndrome coronavirus protein nsp1 is a novel eukaryotic translation inhibitor that represses multiple steps of translation initiation

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A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein

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SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: viral mRNAs are resistant to nsp1-induced RNA cleavage

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Severe acute respiratory syndrome coronavirus evades antiviral signaling: role of nsp1 and rational design of an attenuated strain

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Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

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Identification of residues of SARS-CoV nsp1 that differentially affect inhibition of gene expression and antiviral signaling

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Novel β-Barrel Fold in the Nuclear Magnetic Resonance Structure of the Replicase Nonstructural Protein 1 from the Severe Acute Respiratory Syndrome Coronavirus

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Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29

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Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex

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Lso2 is a conserved ribosome-bound protein required for translational recovery in yeast

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Identifiers

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