ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation (Q95721661)

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29 May 2020

title

ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation (English)

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29 May 2020

1

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29 May 2020

author name string

P K Park

2

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29 May 2020

Y Kim

3

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29 May 2020

C Vaziri

4

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29 May 2020

S L Schreiber

5

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29 May 2020

publication date

1 July 2001

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Proceedings of the National Academy of Sciences of the United States of America

29 May 2020

published in

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29 May 2020

volume

98

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29 May 2020

issue

16

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29 May 2020

page(s)

9092-9097

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Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins

29 May 2020

cites work

1 reference

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Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=55378

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=55378

The DNA damage response: putting checkpoints in perspective

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=55378

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

10 February 2021

1 reference

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Activation of the DNA replication checkpoint through RNA synthesis by primase

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=55378

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=55378

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

10 February 2021

1 reference

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ATR disruption leads to chromosomal fragmentation and early embryonic lethality

10 February 2021

1 reference

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10 February 2021

The Hallmarks of Cancer

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A novel DNA damage checkpoint involving post-transcriptional regulation of cyclin A expression

10 February 2021

1 reference

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Substrate specificities and identification of putative substrates of ATM kinase family members

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=55378

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

10 February 2021

1 reference

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Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

10 February 2021

1 reference

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The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53.

10 February 2021

1 reference

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10 February 2021

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Structure of DNA-dependent protein kinase: implications for its regulation by DNA.

10 February 2021

1 reference

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A role for ATR in the DNA damage-induced phosphorylation of p53

10 February 2021

1 reference

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Tetracycline repressor, tetR, rather than the tetR-mammalian cell transcription factor fusion derivatives, regulates inducible gene expression in mammalian cells

10 February 2021

1 reference

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Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=55378

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein

10 February 2021

1 reference

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Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair

10 February 2021

1 reference

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Abrogation of the G2 checkpoint results in differential radiosensitization of G1 checkpoint-deficient and G1 checkpoint-competent cells

10 February 2021

1 reference

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10 February 2021

1 reference

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Cytosine arabinoside plus cisplatin and other drugs as chemotherapy for gliomas.

10 February 2021

1 reference

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Movement and segregation of kinetochores experimentally detached from mammalian chromosomes

10 February 2021

1 reference

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Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells

10 February 2021

1 reference

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10 February 2021

Identifiers

DOI

10.1073/PNAS.161281798

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29 May 2020

0 references

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29 May 2020

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