7B2 prevents unfolding and aggregation of prohormone convertase 2 (Q95820372)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18467442%20AND%20SRC:MED&resulttype=core&format=json

30 May 2020

title

7B2 prevents unfolding and aggregation of prohormone convertase 2 (English)

1 reference

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30 May 2020

author name string

Sang-Nam Lee

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18467442%20AND%20SRC:MED&resulttype=core&format=json

30 May 2020

Iris Lindberg

series ordinal

2

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30 May 2020

publication date

8 May 2008

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30 May 2020

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30 May 2020

volume

149

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30 May 2020

issue

8

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30 May 2020

page(s)

4116-4127

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describes a project that uses

30 May 2020

ImageQuant

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11 June 2022

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based on heuristic

inferred from PubMed Central ID database lookup

cites work

Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity

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The C-terminus of prohormone convertase 2 is sufficient and necessary for Raft association and sorting to the regulated secretory pathway

10 February 2021

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Mildly acidic pH activates the extracellular molecular chaperone clusterin

10 February 2021

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Solution structure of the pro-hormone convertase 1 pro-domain from Mus musculus

10 February 2021

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The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation

10 February 2021

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10 February 2021

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Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state

10 February 2021

1 reference

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Processing and sorting of the prohormone convertase 2 propeptide

10 February 2021

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Involvement of the membrane lipid bilayer in sorting prohormone convertase 2 into the regulated secretory pathway

10 February 2021

1 reference

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10 February 2021

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A 36-residue peptide contains all of the information required for 7B2-mediated activation of prohormone convertase 2.

10 February 2021

1 reference

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A pathway for conformational diversity in proteins mediated by intramolecular chaperones

10 February 2021

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10 February 2021

1 reference

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The proteolytic maturation of prohormone convertase 2 (PC2) is a pH-driven process.

10 February 2021

1 reference

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Neuroendocrine protein 7B2 is essential for proteolytic conversion and activation of proprotein convertase 2 in vivo.

10 February 2021

1 reference

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Residues unique to the pro-hormone convertase PC2 modulate its autoactivation, binding to 7B2 and enzymatic activity

10 February 2021

1 reference

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Structural elements of PC2 required for interaction with its helper protein 7B2.

10 February 2021

1 reference

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Eukaryotic protein processing: endoproteolysis of precursor proteins

10 February 2021

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Mechanism of the facilitation of PC2 maturation by 7B2: involvement in ProPC2 transport and activation but not folding

10 February 2021

1 reference

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10 February 2021

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The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments

10 February 2021

1 reference

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Purification and enzymatic characterization of recombinant prohormone convertase 2: stabilization of activity by 21 kDa 7B2

10 February 2021

1 reference

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10 February 2021

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10 February 2021

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10 February 2021

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Biosynthesis of the prohormone convertase PC2 in Chinese hamster ovary cells and in rat insulinoma cells

10 February 2021

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10 February 2021

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Evidence for cleavage of the PC1/PC3 pro-segment in the endoplasmic reticulum.

10 February 2021

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The neuroendocrine precursor 7B2 is a sulfated protein proteolytically processed by a ubiquitous furin-like convertase

10 February 2021

1 reference

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Calcium- and pH-dependent aggregation and membrane association of the precursor of the prohormone convertase PC2

10 February 2021

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Endoproteolytic processing of proopiomelanocortin and prohormone convertases 1 and 2 in neuroendocrine cells overexpressing prohormone convertases 1 or 2.

10 February 2021

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The neuroendocrine polypeptide 7B2 is an endogenous inhibitor of prohormone convertase PC2

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2488232

Endoproteolytic cleavage of its propeptide is a prerequisite for efficient transport of furin out of the endoplasmic reticulum

10 February 2021

1 reference

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Maturation of the trans-Golgi network protease furin: compartmentalization of propeptide removal, substrate cleavage, and COOH-terminal truncation

10 February 2021

1 reference

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The neuroendocrine protein 7B2 acts as a molecular chaperone in the in vitro folding of human insulin-like growth factor-1 secreted from yeast

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2488232

7B2 facilitates the maturation of proPC2 in neuroendocrine cells and is required for the expression of enzymatic activity

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2488232

Enzymatic characterization of immunopurified prohormone convertase 2: potent inhibition by a 7B2 peptide fragment

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2488232

7B2 is a specific intracellular binding protein of the prohormone convertase PC2

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2488232

The neuroendocrine chaperone 7B2 can enhance in vitro POMC cleavage by prohormone convertase PC2

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2488232

Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2488232

Pro-sequence of subtilisin can guide the refolding of denatured subtilisin in an intermolecular process.

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2488232

Posttranslational processing of proenkephalin in SK-N-MC cells: evidence for phosphorylation

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2488232

10 February 2021

Identifiers

DOI

10.1210/EN.2008-0064

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18467442%20AND%20SRC:MED&resulttype=core&format=json

30 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18467442%20AND%20SRC:MED&resulttype=core&format=json

30 May 2020

1 reference