Wikidata:Property proposal/Positive modulator (biochemistry)

antisense inhibitor of[edit]

Originally proposed at Wikidata:Property proposal/Natural science

Done: antisense inhibitor of (P3777) (Talk and documentation)

Description	protein/gene for which this chemical (e.g. a miRNA/siRNA) acts as an antisense inhibitor
Data type	Item
Domain	biology, chemistry
Allowed values	Wikidata items of instance of (P31)/subclass of (P279): chemical compound (Q11173) or protein (Q8054)
Example	eteplirsen (Q5402585) → Dystrophin (Q412285)
Source	Guide to Pharmacology, ChEMBL, BindingDB, PDB
Planned use	Several thousand chemical compound to protein relations should be imported

Motivation

We have been importing proteins, chemical compounds and the relations between those and have modeled the relation by using physically interacts with (P129) and qualifiers to indicate the type of relation (e.g. Activator, Inhibitor). This approach is not very convenient. It makes adding data by users more difficult, as well as querying the data with SPARQL and it also makes it impossible to properly map these relations to external resources/ontologies. Therefore, we talked to the folks from ChEMBL and they kindly provided us with their list of chemical compound - protein mechanistic relations. We are currently also getting these relations established in the Relation Ontology which allows for interoperability and direct integration of these relations Wikidata with the OBO world. This is a big advantage, as data contributions to Wikidata can easily disseminate into the OBO world, making community curation in WD even more valuable. In total, there are 29 relations, I will now just propose the 10 most important as properties. Sebotic (talk) 19:05, 6 February 2017 (UTC)[reply]

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