Wikidata:Property proposal/negative prognostic predictor
negative prognostic predictor[edit]
Originally proposed at Wikidata:Property proposal/Natural science
Description | the presence of the genetic variant helps to prognose poor outcome for the disease |
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Data type | Item |
Domain | sequence variant (Q15304597) |
Example | BRAF V600E (Q21851559) → thyroid cancer (Q826522) |
Source | CIViC, ClinVar |
Planned use | To enrich wikidata with facts on sequence variants from CIViC, ClinVar and other variant resources/ |
Robot and gadget jobs | ProteinBoxBot will update wikidata from authoritative resources on sequence variants. |
See also | CIViC, HGVS Nomenclature
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- Motivation
We have already added data on genes, drugs and diseases. Variants are key in linking these concepts for precision medicine and foster discussion in the community. With this property in place we can model the negative prognostic association between a variant and a disease. Together with the provenance and the evidence. This property will allow us to connect a specific variant with evidence pertaining to its clinical significance as a predictor for the negative prognostic of a disease phenotype. Emitraka (talk) 01:34, 12 November 2016 (UTC)
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Notified participants of WikiProject Medicine
- Discussion
- Support This property allows incorporating in Wikidata an important annotation for genetic variation in genomic and precision medicine that is not currently possible. This addition has two great added values: the expressivity for the type of biomarker the variant is, which is key in decision-making, and to clearly track the supporting evidence for each type of biomarker to evaluate the clinical actionability of the genetic variant for disease prognosis. Wikidata is a perfect platform to create community discussion on the clinical value of biomarkers, specially relevant for the biomedical and clinical research community. Nuria Queralt (talk)
- Support --Andrawaag (talk) 06:11, 12 November 2016 (UTC)
- Support Required for modeling of variant/mutation impact in any species. Sebotic (talk) 18:46, 14 November 2016 (UTC)
- Support. This property will allow us to model variants which will make the representation of knowledge in the medical domain more complete. YULdigitalpreservation (talk) 14:25, 15 November 2016 (UTC)
- Support but see above comment on positive diagnostic predictor --I9606 (talk) 20:09, 18 November 2016 (UTC)
- Support Putmantime (talk) 22:00, 18 November 2016 (UTC)
- @Emitraka, NuriaQueralt, Andrawaag, Sebotic, YULdigitalpreservation: @I9606, Putmantime: Done ArthurPSmith (talk) 15:48, 21 November 2016 (UTC)