Nanog homeobox (Q14874557)

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mammalian protein found in Mus musculus
  • early embryo specific expression NK-type homeobox protein
  • homeobox protein NANOG
  • homeobox transcription factor Nanog
  • Nanog
  • early embryo specific expression NK family
  • ES cell-associated protein 4
edit
Language Label Description Also known as
English
Nanog homeobox
mammalian protein found in Mus musculus
  • early embryo specific expression NK-type homeobox protein
  • homeobox protein NANOG
  • homeobox transcription factor Nanog
  • Nanog
  • early embryo specific expression NK family
  • ES cell-associated protein 4

Statements

molecular function
protein binding
determination method or standard
IPI
8 references
retrieved
8 April 2019
stated in
Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming
GOA
curator
UniProt
UniProt protein ID
Q80Z64
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IPI
retrieved
8 April 2019
stated in
Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells.
GOA
curator
UniProt
UniProt protein ID
Q80Z64
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IPI
retrieved
8 April 2019
stated in
Zfp281 functions as a transcriptional repressor for pluripotency of mouse embryonic stem cells
GOA
curator
UniProt
UniProt protein ID
Q80Z64
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IPI
retrieved
8 April 2019
stated in
A protein interaction network for pluripotency of embryonic stem cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation stabilizes Nanog by promoting its interaction with Pin1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IPI
retrieved
8 April 2019
stated in
A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IPI
retrieved
8 April 2019
stated in
Sall1 Regulates Embryonic Stem Cell Differentiation in Association with Nanog
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IPI
retrieved
8 April 2019
stated in
Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IPI
cell component
nucleus
determination method or standard
IDA
IEA
ISO
16 references
retrieved
7 November 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80Z64&geneProductId=UniProtKB:Q80Z64
determination method or standard
ISO
retrieved
7 November 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q80Z64
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80Z64&geneProductId=UniProtKB:Q80Z64
determination method or standard
IEA
retrieved
7 November 2018
stated in
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80Z64&geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
7 November 2018
stated in
Pwp1 is required for the differentiation potential of mouse embryonic stem cells through regulating Stat3 signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80Z64&geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
7 November 2018
stated in
Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80Z64&geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
7 November 2018
stated in
ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80Z64&geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
7 November 2018
stated in
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80Z64&geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
7 November 2018
stated in
The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80Z64&geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
7 November 2018
stated in
CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80Z64&geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
7 November 2018
stated in
Expression of Nanog gene promotes NIH3T3 cell proliferation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80Z64&geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
7 November 2018
stated in
Pluripotential competence of cells associated with Nanog activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80Z64&geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
7 November 2018
stated in
Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80Z64&geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
7 November 2018
stated in
Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80Z64&geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
7 November 2018
stated in
Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80Z64&geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
7 November 2018
stated in
Rbm46 regulates trophectoderm differentiation by stabilizing Cdx2 mRNA in early mouse embryos
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80Z64&geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
7 November 2018
stated in
LRH-1 and Nanog regulate Dax1 transcription in mouse embryonic stem cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80Z64&geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
nucleus
determination method or standard
IBA
IDA
IEA
ISO
17 references
retrieved
8 April 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
ISO
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q80Z64
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IEA
retrieved
8 April 2019
stated in
Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
8 April 2019
stated in
Pluripotential competence of cells associated with Nanog activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
8 April 2019
stated in
Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
8 April 2019
stated in
The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
8 April 2019
stated in
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
8 April 2019
stated in
Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
8 April 2019
stated in
Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
8 April 2019
stated in
ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
8 April 2019
stated in
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
8 April 2019
stated in
Rbm46 regulates trophectoderm differentiation by stabilizing Cdx2 mRNA in early mouse embryos
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
8 April 2019
stated in
Pwp1 is required for the differentiation potential of mouse embryonic stem cells through regulating Stat3 signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
8 April 2019
stated in
Expression of Nanog gene promotes NIH3T3 cell proliferation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
8 April 2019
stated in
CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
8 April 2019
stated in
LRH-1 and Nanog regulate Dax1 transcription in mouse embryonic stem cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IBA
biological process
stem cell population maintenance
determination method or standard
IDA
IEP
IMP
6 references
retrieved
14 February 2019
stated in
Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells
GOA
curator
UniProt
UniProt protein ID
Q80Z64
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IMP
retrieved
14 February 2019
stated in
The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IMP
retrieved
14 February 2019
stated in
Mediator and cohesin connect gene expression and chromatin architecture
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IMP
retrieved
14 February 2019
stated in
Dissecting self-renewal in stem cells with RNA interference
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IMP
retrieved
14 February 2019
stated in
Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IEP
retrieved
14 February 2019
stated in
Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA
stem cell population maintenance
determination method or standard
IDA
IEP
IGI
IMP
7 references
retrieved
8 April 2019
stated in
Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells
GOA
curator
UniProt
UniProt protein ID
Q80Z64
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IMP
retrieved
8 April 2019
stated in
Dissecting self-renewal in stem cells with RNA interference
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IMP
retrieved
8 April 2019
stated in
The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IMP
retrieved
8 April 2019
stated in
Mediator and cohesin connect gene expression and chromatin architecture
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IMP
retrieved
8 April 2019
stated in
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IGI
retrieved
8 April 2019
stated in
Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IEP
retrieved
8 April 2019
stated in
Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80Z64
determination method or standard
IDA

Identifiers

 
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