SMAD family member 1 (Q14903821)

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mammalian protein found in Mus musculus
  • dwarfin-A
  • Smad1
  • MAD homolog 1
  • mothers against decapentaplegic homolog 1
  • mothers-against-DPP-related 1
  • mothers against DPP homolog 1
  • Smad 1
  • mad-related protein 1
  • mMad1
  • dwf-A
edit
Language Label Description Also known as
English
SMAD family member 1
mammalian protein found in Mus musculus
  • dwarfin-A
  • Smad1
  • MAD homolog 1
  • mothers against decapentaplegic homolog 1
  • mothers-against-DPP-related 1
  • mothers against DPP homolog 1
  • Smad 1
  • mad-related protein 1
  • mMad1
  • dwf-A

Statements

molecular function
protein binding
determination method
IPI
9 references
retrieved
14 February 2019
stated in
Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation
GOA
curator
UniProt
UniProt protein ID
P70340
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IPI
retrieved
14 February 2019
stated in
Sertad1 encodes a novel transcriptional co-activator of SMAD1 in mouse embryonic hearts
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IPI
retrieved
14 February 2019
stated in
SUMO interaction motifs in Sizn1 are required for promyelocytic leukemia protein nuclear body localization and for transcriptional activation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IPI
retrieved
14 February 2019
stated in
Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IPI
retrieved
14 February 2019
stated in
Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IPI
retrieved
14 February 2019
stated in
Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IPI
retrieved
14 February 2019
stated in
B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IPI
retrieved
14 February 2019
stated in
Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IPI
retrieved
14 February 2019
stated in
TAK1 is an essential regulator of BMP signalling in cartilage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IPI
cell component
cytoplasm
determination method
IDA
IEA
ISO
6 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P70340
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IEA
retrieved
14 February 2019
stated in
Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins
GOA
curator
UniProt
UniProt protein ID
P70340
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IDA
retrieved
14 February 2019
stated in
Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IDA
retrieved
14 February 2019
stated in
Lack of the bone morphogenetic protein BMP6 induces massive iron overload
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IDA
nucleus
determination method
IDA
IEA
ISO
9 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P70340
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IEA
retrieved
14 February 2019
stated in
Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation
GOA
curator
UniProt
UniProt protein ID
P70340
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IDA
retrieved
14 February 2019
stated in
C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IDA
retrieved
14 February 2019
stated in
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IDA
retrieved
14 February 2019
stated in
Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IDA
retrieved
14 February 2019
stated in
BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IDA
retrieved
14 February 2019
stated in
Lack of the bone morphogenetic protein BMP6 induces massive iron overload
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IDA
biological process
BMP signaling pathway
determination method
ISS
IEA
IGI
IDA
IMP
TAS
ISO
10 references
retrieved
14 February 2019
stated in
Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
TAS
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P70340
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
ISS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
ISO
retrieved
14 February 2019
stated in
In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IMP
retrieved
14 February 2019
stated in
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IGI
retrieved
14 February 2019
stated in
BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IGI
retrieved
14 February 2019
stated in
Lack of the bone morphogenetic protein BMP6 induces massive iron overload
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IGI
retrieved
14 February 2019
stated in
The canonical BMP signaling pathway plays a crucial part in stimulation of dentin sialophosphoprotein expression by BMP-2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IGI
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IEA
retrieved
14 February 2019
stated in
C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IDA
positive regulation of transcription by RNA polymerase II
determination method
IDA
IGI
IEA
ISO
7 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
ISO
retrieved
14 February 2019
stated in
Sertad1 encodes a novel transcriptional co-activator of SMAD1 in mouse embryonic hearts
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IGI
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IEA
retrieved
14 February 2019
stated in
The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IDA
retrieved
14 February 2019
stated in
miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IDA
retrieved
14 February 2019
stated in
Isl1Cre reveals a common Bmp pathway in heart and limb development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IDA
retrieved
14 February 2019
stated in
Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340
determination method
IDA

Identifiers

 
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