cytochrome P450, family 1, subfamily b, polypeptide 1 (Q14905167)

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mammalian protein found in Mus musculus

CYPIB1
cytochrome P450, 1b1, benz[a]anthracene inducible
cytochrome P450CMEF
Cyp1b1
benz[a]anthracene inducible
cytochrome P450EF
cytochrome P450 1B1

Language	Label	Description	Also known as
English	cytochrome P450, family 1, subfamily b, polypeptide 1	mammalian protein found in Mus musculus	CYPIB1 cytochrome P450, 1b1, benz[a]anthracene inducible cytochrome P450CMEF Cyp1b1 benz[a]anthracene inducible cytochrome P450EF cytochrome P450 1B1

Statements

1 reference

12 September 2018

UniProt protein ID

cytochrome P450 superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q64429

Cytochrome P450 1B1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q64429

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

cytochrome P450, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

12 September 2018

UniProt protein ID

1 reference

12 September 2018

UniProt protein ID

molecular function

iron ion binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

Biological oxidations and P450 reactions. Recombinant mouse CYP1B1 expressed in Escherichia coli exhibits selective binding by polycyclic hydrocarbons and metabolism which parallels C3H10T1/2 cell microsomes, but differs from human recombinant CYP1B

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

monooxygenase activity

determination method

6 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

Specificity determinants of CYP1B1 estradiol hydroxylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

determination method

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

aromatase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

organelle membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

endoplasmic reticulum membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

endoplasmic reticulum

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

biological process

intrinsic apoptotic signaling pathway in response to oxidative stress

determination method

steroid metabolic process

determination method

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

nitric oxide biosynthetic process

determination method

1 reference

9 May 2019

CYP1B1 and endothelial nitric oxide synthase combine to sustain proangiogenic functions of endothelial cells under hyperoxic stress

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

blood vessel morphogenesis

determination method

1 reference

9 May 2019

Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

estrogen metabolic process

determination method

collagen fibril organization

determination method

1 reference

9 May 2019

Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

retina vasculature development in camera-type eye

determination method

1 reference

9 May 2019

CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

retinol metabolic process

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

regulation of reactive oxygen species metabolic process

determination method

1 reference

9 May 2019

CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

positive regulation of angiogenesis

determination method

1 reference

9 May 2019

CYP1B1 and endothelial nitric oxide synthase combine to sustain proangiogenic functions of endothelial cells under hyperoxic stress

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

retinal metabolic process

determination method

3 references

membrane lipid catabolic process

determination method

endothelial cell-cell adhesion

determination method

1 reference

9 May 2019

CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

trabecular meshwork development

determination method

1 reference

9 May 2019

Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

determination method

1 reference

9 May 2019

Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

negative regulation of cell migration

determination method

1 reference

9 May 2019

Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

dibenzo-p-dioxin metabolic process

determination method

1 reference

9 May 2019

For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

determination method

1 reference

9 May 2019

CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

retinal blood vessel morphogenesis

determination method

1 reference

9 May 2019

CYP1B1 and endothelial nitric oxide synthase combine to sustain proangiogenic functions of endothelial cells under hyperoxic stress

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

positive regulation of apoptotic process

determination method

1 reference

9 May 2019

Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

xenobiotic metabolic process

determination method

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

positive regulation of vascular endothelial growth factor production

determination method

1 reference

9 May 2019

Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

negative regulation of NF-kappaB transcription factor activity

determination method

1 reference

9 May 2019

Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

arachidonic acid metabolic process

determination method

3 references

response to toxic substance

determination method

1 reference

9 May 2019

Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

negative regulation of cell adhesion mediated by integrin

determination method

1 reference

9 May 2019

Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

endothelial cell migration

determination method

positive regulation of receptor signaling pathway via JAK-STAT

determination method

1 reference

9 May 2019

Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

negative regulation of cell population proliferation

determination method

1 reference

9 May 2019

Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

cellular response to hydrogen peroxide

determination method

1 reference

9 May 2019

Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

DNA modification

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

cellular aromatic compound metabolic process

determination method

5 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

Biological oxidations and P450 reactions. Recombinant mouse CYP1B1 expressed in Escherichia coli exhibits selective binding by polycyclic hydrocarbons and metabolism which parallels C3H10T1/2 cell microsomes, but differs from human recombinant CYP1B

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

Ah receptor regulation of CYP1B1 expression in primary mouse embryo-derived cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

9 May 2019

Purification and immunological characterization of a novel cytochrome P450 from C3H/10T1/2 cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

positive regulation of smooth muscle cell migration

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

benzene-containing compound metabolic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

positive regulation of translation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

positive regulation of reactive oxygen species metabolic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

positive regulation of DNA biosynthetic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

determination method

cytochrome P450, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q64429

Identifiers

RefSeq protein ID

1 reference

14 September 2018

1 reference

14 September 2018

1 reference

14 September 2018

1 reference

14 September 2018

1 reference

17 August 2018

UniProt protein ID

1 reference

12 September 2018

UniProt protein ID

Ensembl protein ID

ENSMUSP00000024894

1 reference

ensembl Release 94

Ensembl protein ID

ENSMUSP00000024894

Sitelinks

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