For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential (Q28586157)

cytochrome P450, family 1, subfamily b, polypeptide 1

GOA release 2020-03-11

1 reference

cytochrome P450, family 1, subfamily a, polypeptide 2

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Nadine Dragin

1

1 reference

31 January 2017

Timothy P. Dalton

2

1 reference

31 January 2017

Marian L. Miller

3

1 reference

31 January 2017

Howard G. Shertzer

4

1 reference

31 January 2017

Daniel W. Nebert

Journal of Biological Chemistry

5

1 reference

31 January 2017

language of work or name

English

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publication date

7 July 2006

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31 January 2017

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31 January 2017

281

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31 January 2017

27

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31 January 2017

18591–18600

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31 January 2017

Does disruption of immune and endocrine systems by environmental toxins contribute to development of endometriosis?

1 reference

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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Related Compounds as Antioestrogens: Characterization and Mechanism of Action

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A novel effect of dioxin: exposure during pregnancy severely impairs mammary gland differentiation

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Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology

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2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

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Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria

21 January 2018

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Dioxin and cancer: a critical review

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Dioxin revisited: developments since the 1997 IARC classification of dioxin as a human carcinogen

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Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis

21 January 2018

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Ah receptor signals cross-talk with multiple developmental pathways

21 January 2018

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A critical review of the developmental toxicity and teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: recent advances toward understanding the mechanism.

21 January 2018

1 reference

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Amelioration of TCDD-induced teratogenesis in aryl hydrocarbon receptor (AhR)-null mice

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Effects of aryl hydrocarbon receptor null mutation and in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on prostate and seminal vesicle development in C57BL/6 mice

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A maternal Ahr null genotype sensitizes embryos to chemical teratogenesis

21 January 2018

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The aryl hydrocarbon receptor is required for developmental closure of the ductus venosus in the neonatal mouse.

21 January 2018

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Validation of Haber's Rule (dose x time = constant) in rats and mice for monochloroacetic acid and 2,3,7,8-tetrachlorodibenzo-p-dioxin under conditions of kinetic steady state

21 January 2018

1 reference

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Xenobiotic receptor knockout mice

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Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor

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Functional role of AhR in the expression of toxic effects by TCDD

21 January 2018

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Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor

21 January 2018

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Molecular mechanisms of AhR functions in the regulation of cytochrome P450 genes

21 January 2018

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Induction of CYP1A1. The AhR/DRE paradigm: transcription, receptor regulation, and expanding biological roles

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Activation of transcription factors activator protein-1 and nuclear factor-kappaB by 2,3,7,8-tetrachlorodibenzo-p-dioxin

21 January 2018

1 reference

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Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels

21 January 2018

1 reference

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4-aminobiphenyl-induced liver and urinary bladder DNA adduct formation in Cyp1a2(-/-) and Cyp1a2(+/+) mice

21 January 2018

1 reference

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Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation

21 January 2018

1 reference

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Bone marrow cytotoxicity of benzo[a]pyrene is dependent on CYP1B1 but is diminished by Ah receptor-mediated induction of CYP1A1 in liver

21 January 2018

1 reference

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Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate

21 January 2018

1 reference

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A dynamic role for the Ah receptor in cell signaling? Insights from a diverse group of Ah receptor interacting proteins

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1 reference

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DNA binding and protein interactions of the AHR/ARNT heterodimer that facilitate gene activation

21 January 2018

1 reference

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Protection of the Cyp1a2(-/-) null mouse against uroporphyria and hepatic injury following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

21 January 2018

1 reference

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Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron

21 January 2018

1 reference

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Uroporphyria and hepatic carcinogenesis induced by polychlorinated biphenyls-iron interaction: absence in the Cyp1a2(-/-) knockout mouse

21 January 2018

1 reference

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Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery

21 January 2018

1 reference

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Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism

21 January 2018

1 reference

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Cytochrome P450-null mice

21 January 2018

1 reference

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Teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the expression of EGF and/or TGF-alpha

21 January 2018

1 reference

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Glutathione redox state regulates mitochondrial reactive oxygen production

21 January 2018

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Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor

21 January 2018

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Chromosomal organization of the cytochrome P450-2C gene family in the mouse: a locus associated with constitutive aryl hydrocarbon hydroxylase

21 January 2018

1 reference

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Effects of CYP1A2 on disposition of 2,3,7, 8-tetrachlorodibenzo-p-dioxin, 2,3,4,7,8-pentachlorodibenzofuran, and 2,2',4,4',5,5'-hexachlorobiphenyl in CYP1A2 knockout and parental (C57BL/6N and 129/Sv) strains of mice

21 January 2018

1 reference

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Cyp1a2 protects against reactive oxygen production in mouse liver microsomes

21 January 2018

1 reference

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Induction of oxidative stress in the tissues of rats after chronic exposure to TCDD, 2,3,4,7,8-pentachlorodibenzofuran, and 3,3',4,4',5-pentachlorobiphenyl

21 January 2018

1 reference

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Induction of cellular oxidative stress by aryl hydrocarbon receptor activation

21 January 2018

1 reference

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Stimulation of calcium uptake in cultured rat hippocampal neurons by 2,3,7,8-tetrachlorodibenzo-p-dioxin

21 January 2018

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Role of p53 tumor suppressor gene in the toxicity of TCDD, endrin, naphthalene, and chromium (VI) in liver and brain tissues of mice

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The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on oxidative enzymes in adipocytes and liver

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Uncoupling-mediated generation of reactive oxygen by halogenated aromatic hydrocarbons in mouse liver microsomes

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Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus

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Theophylline pharmacokinetics: comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice.

21 January 2018

1 reference

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Carcinogenic risks of dioxin: mechanistic considerations

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1 reference

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Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer

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Role of CYP1A2 in hepatic sequestration of dioxin: studies using CYP1A2 knock-out mice

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Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl

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Rapid clearance of hexachlorobenzene from chylomicrons

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Treatment with a dietary fat substitute decreased Arochlor 1254 contamination in an obese diabetic male

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Tissue- and cell type-specific expression of cytochrome P450 1A1 and cytochrome P450 1A2 mRNA in the mouse localized in situ hybridization.

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Dose-response studies on the induction of liver cytochromes P4501A1 and 1B1 by polycyclic aromatic hydrocarbons in arylhydrocarbon-responsive C57BL/6J mice

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Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues

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Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2.

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Inter-individual differences in the metabolism of environmental toxicants: cytochrome P450 1A2 as a prototype

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Polymorphisms in the human AH receptor

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Ethnic variability in the allelic distribution of human aryl hydrocarbon receptor codon 554 and assessment of variant receptor function in vitro

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Functional analysis of six human aryl hydrocarbon receptor variants in a Japanese population

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Human Ah receptor (AHR) gene: localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility

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The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects

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Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer

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Tumour promotion by TCDD in skin of HRS/J hairless mice

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