Protein tyrosine phosphatase, non-receptor type 11 (Q14905498)

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mammalian protein found in Mus musculus
  • Shp2
  • SH2 domain-containing protein tyrosine phosphatase-2
  • protein-tyrosine phosphatase SYP
  • SHP-2
  • tyrosine-protein phosphatase non-receptor type 11
  • Ptpn11
  • SH-PTP2
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Language Label Description Also known as
English
Protein tyrosine phosphatase, non-receptor type 11
mammalian protein found in Mus musculus
  • Shp2
  • SH2 domain-containing protein tyrosine phosphatase-2
  • protein-tyrosine phosphatase SYP
  • SHP-2
  • tyrosine-protein phosphatase non-receptor type 11
  • Ptpn11
  • SH-PTP2

Statements

molecular function
protein binding
determination method
IPI
22 references
retrieved
8 April 2019
stated in
An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions
GOA
curator
UniProt
UniProt protein ID
P35235
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
retrieved
8 April 2019
stated in
Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function
GOA
curator
UniProt
UniProt protein ID
P35235
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
retrieved
8 April 2019
stated in
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
retrieved
8 April 2019
stated in
Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
retrieved
8 April 2019
stated in
The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
retrieved
8 April 2019
stated in
FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
retrieved
8 April 2019
stated in
Gab3, a new DOS/Gab family member, facilitates macrophage differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
retrieved
8 April 2019
stated in
The murine ortholog of the SHP-2 binding molecule, PZR accelerates cell migration on fibronectin and is expressed in early embryo formation.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
retrieved
8 April 2019
stated in
B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
retrieved
8 April 2019
stated in
Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
retrieved
8 April 2019
stated in
Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
retrieved
8 April 2019
stated in
The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
retrieved
8 April 2019
stated in
Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
retrieved
8 April 2019
stated in
Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
retrieved
8 April 2019
stated in
Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
retrieved
8 April 2019
stated in
Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
retrieved
8 April 2019
stated in
Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
retrieved
8 April 2019
stated in
Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
retrieved
8 April 2019
stated in
Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
retrieved
8 April 2019
stated in
B cell antigen receptor (BCR)-mediated formation of a SHP-2-pp120 complex and its inhibition by Fc gamma RIIB1-BCR coligation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
retrieved
8 April 2019
stated in
Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
retrieved
8 April 2019
stated in
LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235
determination method
IPI
cell component
biological process

Identifiers

 
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