Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation (Q28594140)

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31 December 2019

title

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation (English)

2 references

31 January 2017

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Protein tyrosine phosphatase, non-receptor type 11

31 December 2019

main subject

1 reference

GOA release 2020-03-11

1 reference

5

1 reference

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31 December 2019

author name string

Toshiyuki Araki

1

2 references

31 January 2017

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31 December 2019

Wentian Yang

7

2 references

31 January 2017

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31 December 2019

M Golam Mohi

2

1 reference

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31 December 2019

Fraz A Ismat

3

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31 December 2019

Roderick T Bronson

4

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31 December 2019

Jeffery L Kutok

6

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31 December 2019

Lily I Pao

8

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31 December 2019

D Gary Gilliland

9

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31 December 2019

Jonathan A Epstein

10

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31 December 2019

Benjamin G Neel

11

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31 December 2019

language of work or name

English

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publication date

25 July 2004

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31 December 2019

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31 December 2019

volume

10

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31 December 2019

page(s)

849-857

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31 December 2019

issue

8

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31 January 2017

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Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

31 December 2019

cites work

1 reference

PTPN11 (Protein-Tyrosine Phosphatase, Nonreceptor-Type 11) Mutations in Seven Japanese Patients with Noonan Syndrome

21 April 2017

1 reference

The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

21 April 2017

1 reference

Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors

21 April 2017

1 reference

Crystal structure of the tyrosine phosphatase SHP-2

21 April 2017

1 reference

Nf1 has an essential role in endothelial cells

21 April 2017

1 reference

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

21 April 2017

1 reference

Met, metastasis, motility and more

21 April 2017

1 reference

Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells

21 April 2017

1 reference

Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation

21 April 2017

1 reference

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

21 April 2017

1 reference

Spatial and temporal patterns of ERK signaling during mouse embryogenesis

21 April 2017

1 reference

Critical role for Gab2 in transformation by BCR/ABL

21 April 2017

1 reference

Hypertelorism With Turner Phenotype

21 April 2017

1 reference

7 January 2021

1 reference

7 January 2021

Noonan syndrome. An update and review for the primary pediatrician

1 reference

7 January 2021

Congenital heart diseases in children with Noonan syndrome: An expanded cardiac spectrum with high prevalence of atrioventricular canal

1 reference

7 January 2021

Noonan syndrome: Structural abnormalities of the mitral valve causing subaortic obstruction

1 reference

7 January 2021

Noonan syndrome and aortic coarctation

1 reference

7 January 2021

Cardiac findings in 31 patients with Noonan's syndrome

1 reference

7 January 2021

Occurrence of myeloproliferative disorder in patients with Noonan syndrome

1 reference

7 January 2021

Noonan's syndrome in association with acute leukemia.

1 reference

7 January 2021

PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) mutations in seven Japanese patients with Noonan syndrome

1 reference

7 January 2021

PTPN11 mutations in Noonan syndrome type I: detection of recurrent mutations in exons 3 and 13.

1 reference

7 January 2021

PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity

1 reference

7 January 2021

Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.

1 reference

7 January 2021

Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps

1 reference

7 January 2021

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

1 reference

7 January 2021

Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

1 reference

7 January 2021

Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia

1 reference

7 January 2021

Spectrum of mutations in PTPN11 and genotype-phenotype correlation in 96 patients with Noonan syndrome and five patients with cardio-facio-cutaneous syndrome

1 reference

7 January 2021

Noonan's Syndrome: Abnormalities of the Growth Hormone/IGF-I Axis and the Response to Treatment with Human Biosynthetic Growth Hormone

1 reference

7 January 2021

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

1 reference

7 January 2021

Exclusion of allelism of Noonan syndrome and neurofibromatosis-type 1 in a large family with Noonan syndrome-neurofibromatosis association

1 reference

7 January 2021

Developing models of DiGeorge syndrome

1 reference

7 January 2021

Correlation between PTPN11 gene mutations and congenital heart defects in Noonan and LEOPARD syndromes.

1 reference

7 January 2021

Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

1 reference

7 January 2021

Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

1 reference

7 January 2021

Hematopoiesis: progenitors and their genetic program

1 reference

7 January 2021

Tie2-Cre-induced inactivation of a conditional mutant Nf1 allele in mouse results in a myeloproliferative disorder that models juvenile myelomonocytic leukemia

1 reference

7 January 2021

Missing pieces in the NF-kappaB puzzle

1 reference

7 January 2021

Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor

1 reference

7 January 2021

Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation

1 reference

7 January 2021

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

1 reference

7 January 2021

Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement.

1 reference

7 January 2021

Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment

1 reference

7 January 2021

Identifiers

2 references

31 January 2017

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release_3guzlxnrlnh5xaxt5ersizntu4

31 December 2019

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Fatcat

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31 January 2017

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