Hemojuvelin BMP co-receptor (Q14905787)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Mus musculus

repulsive guidance molecule C
Hjv
hemochromatosis type 2 (juvenile) (human homolog)
hemochromatosis type 2 protein homolog
Hfe2
RGM domain family member C
hemojuvelin
hemojuvelin BMP coreceptor

Language	Label	Description	Also known as
English	Hemojuvelin BMP co-receptor	mammalian protein found in Mus musculus	repulsive guidance molecule C Hjv hemochromatosis type 2 (juvenile) (human homolog) hemochromatosis type 2 protein homolog Hfe2 RGM domain family member C hemojuvelin hemojuvelin BMP coreceptor

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q7TQ32

Mog1/PsbP, alpha/beta/alpha sandwich

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q7TQ32

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Repulsive guidance molecule, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Repulsive guidance molecule, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

coreceptor activity

determination method

4 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7TQ32&geneProductId=UniProtKB:Q7TQ32

determination method

24 April 2018

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7TQ32&geneProductId=UniProtKB:Q7TQ32

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7TQ32&geneProductId=UniProtKB:Q7TQ32

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7TQ32&geneProductId=UniProtKB:Q7TQ32

determination method

determination method

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

coreceptor activity

determination method

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

plasma membrane

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

determination method

1 reference

14 February 2019

Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

anchored component of membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

extracellular space

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

basolateral plasma membrane

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

biological process

iron ion homeostasis

determination method

8 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Iron-dependent regulation of hepcidin in Hjv-/- mice: evidence that hemojuvelin is dispensable for sensing body iron levels

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Hemojuvelin is essential for transferrin-dependent and transferrin-independent hepcidin expression in mice

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

14 February 2019

Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

BMP signaling pathway

determination method

7 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7TQ32&geneProductId=UniProtKB:Q7TQ32

determination method

24 April 2018

Iron-dependent regulation of hepcidin in Hjv-/- mice: evidence that hemojuvelin is dispensable for sensing body iron levels

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7TQ32&geneProductId=UniProtKB:Q7TQ32

determination method

24 April 2018

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7TQ32&geneProductId=UniProtKB:Q7TQ32

determination method

24 April 2018

Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7TQ32&geneProductId=UniProtKB:Q7TQ32

determination method

24 April 2018

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7TQ32&geneProductId=UniProtKB:Q7TQ32

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7TQ32&geneProductId=UniProtKB:Q7TQ32

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7TQ32&geneProductId=UniProtKB:Q7TQ32

determination method

negative regulation of BMP signaling pathway

determination method

1 reference

14 February 2019

Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

positive regulation of transcription by RNA polymerase II

determination method

6 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

cellular iron ion homeostasis

determination method

1 reference

14 February 2019

Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

BMP signaling pathway

determination method

8 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Iron-dependent regulation of hepcidin in Hjv-/- mice: evidence that hemojuvelin is dispensable for sensing body iron levels

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7TQ32

determination method

Repulsive guidance molecule, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q7TQ32

Repulsive guidance molecule, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q7TQ32

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000046659

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000046659

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q14905787&oldid=2023070243"