Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload (Q28587039)

31 January 2017

title

Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload (English)

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31 January 2017

main subject

Transferrin receptor 2

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Homeostatic iron regulator

GOA release 2020-03-11

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Hemojuvelin BMP co-receptor

GOA release 2020-03-11

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Katarzyna Mleczko-Sanecka

GOA release 2020-03-11

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3

object named as

Katarzyna Mleczko-Sanecka

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31 January 2017

9

Martina U. Muckenthaler

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31 January 2017

Maja Vujić Spasić

1

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31 January 2017

Richard Sparla

2

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31 January 2017

Mary C. Migas

4

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31 January 2017

Katja Breitkopf-Heinlein

5

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31 January 2017

Steven Dooley

6

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31 January 2017

Sophie Vaulont

7

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31 January 2017

Robert E. Fleming

8

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31 January 2017

language of work or name

English

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publication date

1 January 2013

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Biochimica et Biophysica Acta

31 January 2017

published in

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31 January 2017

volume

1832

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31 January 2017

issue

1

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31 January 2017

page(s)

76–84

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BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

31 January 2017

cites work

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12 December 2020

A mouse model of juvenile hemochromatosis

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12 December 2020

Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis

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12 December 2020

BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression.

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12 December 2020

Altered hepatic BMP signaling pathway in human HFE hemochromatosis

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12 December 2020

BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk

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12 December 2020

SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression

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12 December 2020

Duodenal HFE expression and hepcidin levels determine body iron homeostasis: modulation by genetic diversity and dietary iron availability

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12 December 2020

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.

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12 December 2020

The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo

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12 December 2020

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

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12 December 2020

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

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12 December 2020

Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR

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12 December 2020

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

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12 December 2020

Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis

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12 December 2020

Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.

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12 December 2020

Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways.

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12 December 2020

Physiologic systemic iron metabolism in mice deficient for duodenal Hfe

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12 December 2020

Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members

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12 December 2020

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

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12 December 2020

Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

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12 December 2020

Negative regulation of TGF-beta receptor/Smad signal transduction.

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12 December 2020

Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis

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12 December 2020

Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis

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12 December 2020

Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.

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12 December 2020

Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice

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12 December 2020

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload

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12 December 2020

Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe

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12 December 2020

Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis

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12 December 2020

Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload.

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12 December 2020

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

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12 December 2020

Understanding iron homeostasis through genetic analysis of hemochromatosis and related disorders

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12 December 2020

A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA

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12 December 2020

Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases

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12 December 2020

Iron homeostasis: insights from genetics and animal models

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12 December 2020

10.1016/J.BBADIS.2012.08.013

Identifiers

DOI

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31 January 2017

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